Results 1 to 10 of about 37,255 (173)
Structure-based characterization of multiprotein complexes. [PDF]
Structure, 2014 Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of ...
Wiederstein M +4 more
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Very Stable High-Molecular-Mass Multiprotein Complexes in Different Organs of the Sea Cucumber Paracaudina chilensis [PDF]
MoleculesWe report the first identification of several large (1.4–2.2 MDa), highly stable protein–peptide complexes in various organs and tissues (body wall, gonads, respiratory trees, gut, and coelomic fluid) of the sea cucumber Paracaudina chilensis.
Svetlana E. Soboleva +5 more
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Multiprotein Complexes of Plant Glycosyltransferases Involved in Their Function and Trafficking [PDF]
PlantsPlant cells utilize protein oligomerization for their functions in numerous important cellular processes. Protein-protein interactions are necessary to stabilize, optimize, and activate enzymes, as well as localize proteins to specific organelles and ...
Ning Zhang +2 more
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Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
Life, 2022 The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and ...
Fan Yang +4 more
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Visualization of multiprotein complexes by flow cytometry. [PDF]
Curr Protoc Immunol, 2009 AbstractMultiprotein complexes and other protein‐protein interactions play important roles in virtually all cellular processes. Analysis of coimmunoprecipitation of protein complexes by flow cytometry (IP‐FCM, or “the fly‐p” method) provides a sensitive means to measure these interactions in the native/nondenatured state.
Schrum AG.
europepmc +4 more sources
Ion channels as part of macromolecular multiprotein complexes : Clinical significance. [PDF]
Herzschrittmacherther Elektrophysiol, 2018 Ion channels and Ca2+-handling proteins involved in the regulation of cardiac electrophysiology and contractility are organized in macromolecular multiprotein complexes. Recent molecular and cellular studies have significantly enhanced our understanding of the composition of these macromolecular complexes and have helped to elucidate their role in the ...
Heijman J, Dobrev D.
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Novel methods for studying multiprotein complexes in vivo. [PDF]
F1000Prime Rep, 2013 The current consensus is that the majority of proteins act in concert in the cell, as homo- and heteromeric complexes of two or more proteins that carry out discrete biological functions. A wide range of genomic, proteomic, biochemical, structural and biophotonic techniques have been employed over the years to study the protein-protein interactions ...
Mehta V, Trinkle-Mulcahy L.
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MultiBac: expanding the research toolbox for multiprotein complexes. [PDF]
Trends Biochem Sci, 2012 Protein complexes composed of many subunits carry out most essential processes in cells and, therefore, have become the focus of intense research. However, deciphering the structure and function of these multiprotein assemblies imposes the challenging task of producing them in sufficient quality and quantity.
Bieniossek C +3 more
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MAP kinases associate with high molecular weight multiprotein complexes. [PDF]
J Exp Bot, 2018 Plant responses to the environment and developmental processes are mediated by a complex signaling network. The Arabidopsis thaliana mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 and their orthologs in other plants are shared signal transducers that respond to many developmental and environmental signals and thus represent highly connected ...
Bequette CJ +4 more
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Geometric modeling of subcellular structures, organelles, and multiprotein complexes. [PDF]
Int J Numer Method Biomed Eng, 2012 SUMMARYRecently, the structure, function, stability, and dynamics of subcellular structures, organelles, and multiprotein complexes have emerged as a leading interest in structural biology. Geometric modeling not only provides visualizations of shapes for large biomolecular complexes but also fills the gap between structural information and theoretical
Feng X, Xia K, Tong Y, Wei GW.
europepmc +4 more sources