Results 11 to 20 of about 37,255 (173)

Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration [PDF]

Nature Communications
Stem cells continually self-renew and differentiate to sustain tissue homeostasis, yet the role of post-transcriptional mechanisms in guiding these processes remains incompletely understood.
Nikolaos Tsopoulidis, Masaki Yagi, Justin Brumbaugh, Shinya Ito, Víctor López-Soriano, Robert Morris, Yoseop Yoon, Kathleen A. Messemer, Kuan-Hung Lin, Eric F. Zaniewski, Rebecca Gorelov, Aaron J. Huebner, Amy J. Wagers, Hanno Hock, Günter Kramer, Bernd Bukau, Michael S. Hoetker, Yongsheng Shi, Wilhelm Haas, Konrad Hochedlinger   +19 more
doaj   +2 more sources

Organization of multiprotein complexes at cell-cell junctions. [PDF]

Histochem Cell Biol, 2008
The formation of stable cell-cell contacts is required for the generation of barrier-forming sheets of epithelial and endothelial cells. During various physiological processes like tissue development, wound healing or tumorigenesis, cellular junctions are reorganized to allow the release or the incorporation of individual cells.
Ebnet K.
europepmc   +4 more sources

Multicolour fluorescence-detection size-exclusion chromatography for structural genomics of membrane multiprotein complexes. [PDF]

PLoS ONE, 2013
Many interesting and important membrane proteins are hetero-oligomeric. However, besides naturally abundant examples, the structures of relatively few such complexes are known.
David Parcej, Renate Guntrum, Sabine Schmidt, Andreas Hinz, Robert Tampé   +4 more
doaj   +2 more sources

Assembly of multiprotein complexes that control genome function. [PDF]

J Cell Biol, 2009
Live-cell imaging studies aided by mathematical modeling have provided unprecedented insight into assembly mechanisms of multiprotein complexes that control genome function. Such studies have unveiled emerging properties of chromatin-associated systems involved in DNA repair and transcription.
Dinant C, Luijsterburg MS, Höfer T, von Bornstaedt G, Vermeulen W, Houtsmuller AB, van Driel R.   +6 more
europepmc   +7 more sources

Equi‐MOI ratio for rapid baculovirus‐mediated multiprotein co‐expression in insect cells integrating selenomethionine for structural studies [PDF]

FEBS Open Bio
Proteins often co‐exist as multicomponent assemblies, making their co‐expression essential in recombinant production processes. The baculovirus expression vector system is commonly used to produce recombinant multiprotein complexes mostly for structural ...
Andrej Bitala, Mário Benko, Marek Nemčovič, Ivana Nemčovičová   +3 more
doaj   +2 more sources

Poxvirus multiprotein entry–fusion complex [PDF]

Proceedings of the National Academy of Sciences, 2005
Poxviruses have evolved elaborate mechanisms for cell entry, assembly, and exocytosis. Recently, four vaccinia virus membrane proteins, namely A21, A28, H2 and L5, were reported to be necessary for cell entry and virus-induced cell–cell fusion but not for virion morphogenesis or attachment of virus particles to cells.
Tatiana G, Senkevich, Suany, Ojeda, Alan, Townsley, Gretchen E, Nelson, Bernard, Moss   +4 more
openaire   +2 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Inflammasomes driven inflammation in lung cancer revisited: a short review

Exploration of Immunology, 2023
Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among other mechanisms, can increase the risk of cancer by ...
Vitor Rodrigues da Costa, Olívia Fonseca Souza, Michelli Ramires Teixeira, Anderson Lucas Alievi, Hugo Vigerelli, Rodrigo Pinheiro Araldi   +5 more
doaj   +1 more source

Quis Custodiet Ipsos Custodes (Who Controls the Controllers)? Two Decades of Studies on HDAC9

Life, 2021
Understanding how an epigenetic regulator drives different cellular responses can be a tricky task. Very often, their activities are modulated by large multiprotein complexes, the composition of which is context- and time-dependent.
Claudio Brancolini, Eros Di Giorgio, Luigi Formisano, Teresa Gagliano   +3 more
doaj   +1 more source

Genetic code expansion for multiprotein complex engineering [PDF]

Nature Methods, 2016
We present a baculovirus-based protein engineering method that enables site-specific introduction of unique functionalities in a eukaryotic protein complex recombinantly produced in insect cells. We demonstrate the versatility of this efficient and robust protein production platform, 'MultiBacTAG', (i) for the fluorescent labeling of target proteins ...
Christine Koehler, Paul F Sauter, Mirella Wawryszyn, Gemma Estrada Girona, Kapil Gupta, Jonathan J M Landry, Markus Hsi-Yang Fritz, Ksenija Radic, Jan-Erik Hoffmann, Zhuo A Chen, Juan Zou, Piau Siong Tan, Bence Galik, Sini Junttila, Peggy Stolt-Bergner, Giancarlo Pruneri, Attila Gyenesei, Carsten Schultz, Moritz Bosse Biskup, Hueseyin Besir, Vladimir Benes, Juri Rappsilber, Martin Jechlinger, Jan O Korbel, Imre Berger, Stefan Braese, Edward A Lemke   +26 more
openaire   +5 more sources