Results 21 to 30 of about 37,255 (173)
Identification and analysis of multi-protein complexes in placenta. [PDF]
PLoS ONE, 2013 Placental malfunction induces pregnancy disorders which contribute to life-threatening complications for both the mother and the fetus. Identification and characterization of placental multi-protein complexes is an important step to integratedly ...
Fuqiang Wang +3 more
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Fine-Tuning Multiprotein Complexes Using Small Molecules [PDF]
ACS Chemical Biology, 2012 Multiprotein complexes such as the transcriptional machinery, signaling hubs, and protein folding machines are typically composed of at least one enzyme combined with multiple non-enzymes. Often the components of these complexes are incorporated in a combinatorial manner, in which the ultimate composition of the system helps dictate the type, location,
Thompson, Andrea D +3 more
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Nature Communications, 2020 Eukaryotic replisomes are multiprotein complexes. Here the authors reveal two distinct stressed replisomes, associated with DONSON and FANCM, displaying a bias in replication timing and chromatin domain.
Jing Zhang +9 more
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Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleation. [PDF]
PLoS ONE, 2013 Microtubules are the main constituents of mitotic spindles. They are nucleated in large amounts during spindle assembly, from multiprotein complexes containing γ-tubulin and associated γ-tubulin complex proteins (GCPs).
Olivier Cala +6 more
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Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes
Pathogens, 2019 Flavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins.
Hussin A. Rothan, Mukesh Kumar
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Biological Procedures Online, 2002 There is accumulating evidence that membrane-bound receptors interact with many intracellular proteins. Multiprotein complexes associated with ionotropic receptors have been extensively characterized, but the identification of proteins interacting with G
Bécamel Carine +6 more
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Cells, 2020 The aberrant function of chromatin regulatory networks (epigenetics) is a hallmark of cancer promoting oncogenic gene expression. A growing body of evidence suggests that the disruption of specific chromatin-associated protein complexes has therapeutic ...
Florian Perner, Scott A. Armstrong
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Assembly and regulation of γ-tubulin complexes [PDF]
Open Biology, 2018 Microtubules are major constituents of the cytoskeleton in all eukaryotic cells. They are essential for chromosome segregation during cell division, for directional intracellular transport and for building specialized cellular structures such as cilia or
Dorian Farache +3 more
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Purifi cation of Multiprotein Histone Acetyltransferase Complexes [PDF]
, 2011 The reversible acetylation of specific lysine residues on core histones regulates gene transcription in eukaryotes. Since the discovery of GCN5 as the first transcription-regulating histone acetyltransferase (HAT), a variety of HATs have now been identified and shown to acetylate different sites on histones as well as on non-histone proteins, including
Yuan-Liang, Wang +2 more
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SmartBac, a new baculovirus system for large protein complex production
Journal of Structural Biology: X, 2019 Recent revolution of cryo-electron microscopy has opened a new door to solve high-resolution structures of macromolecule complexes without crystallization while how to efficiently obtain homogenous macromolecule complex sample is therefore becoming a ...
Yujia Zhai +4 more
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