Results 51 to 60 of about 37,255 (173)
Examining multiprotein signaling complexes from all angles. [PDF]
The FEBS journal, 2005 Dynamic protein-protein interactions are involved in most physiological processes and, in particular, for the formation of multiprotein signaling complexes at transmembrane receptors, adapter proteins and effector molecules. Because the unregulated induction of signaling complexes has substantial clinical relevance, the investigation of these complexes
Jon C D, Houtman +2 more
openaire +3 more sources
Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
eLife, 2022 The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology.
Polina Kosillo +6 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ischemic reperfusion injury (IRI) to kidney is a significant clinical factor in acute kidney injury (AKI). This study aimed to investigate the new role of RNA‐binding motif protein X‐linked (RBMX), a modulator of m6A methylation, in renal IRI and to examine the associated regulatory mechanisms. An in vitro renal IRI model was established using
Yi‐Han Wang +4 more
wiley +1 more source
Nature Communications, 2017 Multiciliogenesis requires activation of transcriptional and protein assembly programs; however, the mechanisms that initiate the formation of these multiprotein complexes are unclear. Here the authors show that after inducing centriole biogenesis genes,
Munemasa Mori +9 more
doaj +1 more source
Gap junctional channels are parts of multiprotein complexes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 Gap junctional channels are a class of membrane channels composed of transmembrane channel-forming integral membrane proteins termed connexins, innexins or pannexins that mediate direct cell-to-cell or cell-to extracellular medium communication in almost all animal tissues.
Hervé, Jean-Claude +4 more
openaire +2 more sources
Long‐term remission in gout: Challenges and future opportunities
Rheumatology &Autoimmunity, EarlyView.Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley +1 more source
Glucose-Specific Enzyme IIA Has Unique Binding Partners in The
mBio, 2012 Glucose-specific enzyme IIA (EIIAGlc) is a central regulator of bacterial metabolism and an intermediate in the phosphoenolpyruvate phosphotransferase system (PTS), a conserved phosphotransfer cascade that controls carbohydrate transport.
Bradley S. Pickering +2 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye +5 more
wiley +1 more source
Condensin I reveals new insights on mouse meiotic chromosome structure and dynamics. [PDF]
PLoS ONE, 2007 Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin
Alberto Viera +6 more
doaj +1 more source
STAR Protocols, 2022 Summary: Dysregulation of the transcriptional or translational machinery can alter the stoichiometry of multiprotein complexes and occurs in natural processes such as aging. Loss of stoichiometry has been shown to alter protein complex functions.
Stefan Hinz +2 more
doaj +1 more source