Results 21 to 30 of about 19,858 (239)

Recovering Actives in Multi-Antitarget and Target Design of Analogs of the Myosin II Inhibitor Blebbistatin

Frontiers in Chemistry, 2018
In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus test the limits of available technology, be that in screening large databases of compounds vs ...
Bart I. Roman, Bart I. Roman, Rita C. Guedes, Christian V. Stevens, Christian V. Stevens, Alfonso T. García-Sosa   +5 more
doaj   +1 more source

Uncovering the Potential Mechanisms of Coptis chinensis Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis

Drug Design, Development and Therapy, 2022
Yiyu Qi,1 Saijia Ni,2 Xia Heng,1 Shuyue Qu,1 Pingyuan Ge,1 Xin Zhao,1 Zengying Yao,2 Rui Guo,3 Nianyun Yang,1 Qichun Zhang,2 Huaxu Zhu1 1Department of Traditional Chinese Medicine Processing and Preparation, Nanjing University of Chinese Medicine ...
Qi Y, Ni S, Heng X, Qu S, Ge P, Zhao X, Yao Z, Guo R, Yang N, Zhang Q, Zhu H   +10 more
doaj  

Multitargeted therapies for multiple myeloma [PDF]

Autophagy, 2013
Multiple myeloma (MM) comprises 1% of all malignancies and 10% of all hematological malignancies. MM is a malignancy of plasma cells in the bone marrow where complex and dynamic interactions with the bone marrow microenvironment lead to tumor progression, skeletal destruction and angiogenesis.
Pedram, Kharaziha, Sophia, Ceder, Claire, Sanchez, Theocharis, Panaretakis   +3 more
openaire   +2 more sources

Deep Sequencing Transcriptome Analysis of Murine Wound Healing: Effects of a Multicomponent, Multitarget Natural Product Therapy-Tr14

Frontiers in Molecular Biosciences, 2017
Wound healing involves an orchestrated response that engages multiple processes, such as hemostasis, cellular migration, extracellular matrix synthesis, and in particular, inflammation.
Georges St. Laurent, Georges St. Laurent, Bernd Seilheimer, Michael Tackett, Jianhua Zhou, Jianhua Zhou, Dmitry Shtokalo, Dmitry Shtokalo, Dmitry Shtokalo, Yuri Vyatkin, Yuri Vyatkin, Maxim Ri, Maxim Ri, Ian Toma, Dan Jones, Timothy A. McCaffrey   +15 more
doaj   +1 more source

Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target

Molecules, 2020
The current therapeutic approach for the treatment of hormone dependent breast cancer includes interference with estrogen receptors via either selective modulators or estrogens deprivation, by preventing their biosynthesis with aromatase inhibitors ...
Jessica Caciolla, Alessandra Bisi, Federica Belluti, Angela Rampa, Silvia Gobbi   +4 more
doaj   +1 more source

High-Throughput Screening and Molecular Dynamics Simulation of Natural Product-like Compounds against Alzheimer’s Disease through Multitarget Approach

Pharmaceuticals, 2021
Alzheimer’s disease (AD) is a progressive neurological disorder that affects 50 million people. Despite this, only two classes of medication have been approved by the FDA. Therefore, we have planned to develop therapeutics by multitarget approach.
Danish Iqbal, Md Tabish Rehman, Abdulaziz Bin Dukhyil, Syed Mohd Danish Rizvi, Mohamed F. Al Ajmi, Bader Mohammed Alshehri, Saeed Banawas, M. Salman Khan, Wael Alturaiki, Mohammed Alsaweed   +9 more
doaj   +1 more source

Design of Multifaceted Antioxidants: Shifting towards Anti-Inflammatory and Antihyperlipidemic Activity

Molecules, 2021
Oxidative stress and inflammation are two conditions that coexist in many multifactorial diseases such as atherosclerosis and neurodegeneration. Thus, the design of multifunctional compounds that can concurrently tackle two or more therapeutic targets is
Ariadni Tzara, George Lambrinidis, Angeliki Kourounakis   +2 more
doaj   +1 more source

Multitarget Drugs: an Epigenetic Epiphany [PDF]

ChemMedChem, 2016
AbstractEpigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes. These dynamic changes are carried out by enzymes and modulate protein–protein and protein–nucleic acid interactions ...
openaire   +4 more sources

Multitarget-Based Virtual Screening for Identification of Herbal Substances toward Potential Osteoclastic Targets

Applied Sciences, 2022
Osteoporosis is a complex bone disease indicating porous bone with low bone mass density and fragility. Cathepsin K, V-ATPase, and αVβ3 integrin are exhibited as novel targets for osteoporosis treatment.
Siripat Chaichit, Pathomwat Wongrattanakamon, Busaban Sirithunyalug, Piyarat Nimmanpipug, Supat Jiranusornkul   +4 more
doaj   +1 more source

Inside Perspective of the Synthetic and Computational Toolbox of JAK Inhibitors: Recent Updates

Molecules, 2020
The mechanisms of inflammation and cancer are intertwined by complex networks of signaling pathways. Dysregulations in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway underlie several pathogenic conditions related to ...
Adriana Coricello, Francesco Mesiti, Antonio Lupia, Annalisa Maruca, Stefano Alcaro   +4 more
doaj   +1 more source