Results 91 to 100 of about 9,651 (201)
The Journal of Physiology, EarlyView.Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera +6 more
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Citation: 'multitarget drug discovery' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12688 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
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Multitargeting epi-epi drugs for multidrug reistance [PDF]
, 2020 Epigenetic therapy is now a clinical reality with eight approved drugs that target DNA methyltransferases, histone deacetylases (HDACs) and lysine methyltransferases. A further recent development is the concept of epigenetic multitargeting through the rational design of novel agents that combine the inhibition of an epigenetic pathway with a second non-
Lee, Adam +6 more
openaire
Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis
eFood, Volume 7, Issue 3, June 2026.Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng +5 more
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Regulated Cell Death in Idiopathic Pulmonary Fibrosis
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan +10 more
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Cancer Medicine, Volume 15, Issue 5, May 2026.ABSTRACT Background Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death worldwide. Cyclin‐dependent kinase 4 (CDK4) is a well‐validated oncogenic driver in NSCLC, yet current CDK4 inhibitors—predominantly based on the aminopyrimidine scaffold—are limited by structural homogeneity and the rapid emergence of acquired ...
Xinyu Chi +5 more
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Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa +17 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.This study shows that Yangyin Tongnao (YYTN) granule alleviates brain damage and functional deficits in MCAO rats. Mechanistically, YYTN inhibits the activation of the JAK2/STAT3 signaling pathway and downstream NLRP3 inflammasome and reduces both systemic (plasma IL‐18, TNF‐α) and local cerebral (IL‐6, IL‐1β mRNA) inflammatory markers.
Yangyang Zhang +7 more
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Food Frontiers, Volume 7, Issue 3, May 2026.Rosa roxburghii‐derived exosome‐like nanovesicles target the intestine, repairing barriers, regulating gut microbiota, balancing Th17/Treg, and combating oxidative stress/inflammation to alleviate colitis, a promising UC therapy. ABSTRACT Plant‐derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of ...
Yuanyuan Wang +8 more
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