Results 81 to 90 of about 9,651 (201)

Drugst.One DREAM—Drug repurposing through expert annotation and modification

British Journal of Pharmacology, EarlyView.
Background and Purpose Complex diseases often lack an actionable understanding of their underlying causal biological mechanisms, which leads to treating symptoms rather than causes. Network and systems medicine define disease mechanisms through disease‐associated genes, their encoded proteins and their protein–protein interactions (PPIs), thus forming ...
Lisa M. Spindler, Johannes Kersting, Quirin Manz, Michael Hartung, Andreas Maier, Zeinab M. Mamdouh, Ana I. Casas, Jan Baumbach, Markus List   +8 more
wiley   +1 more source

Current prevalence and therapeutic strategies for porcine Streptococcus suis in China

Applied and Environmental Microbiology
Porcine Streptococcus suis is a zoonotic bacterial pathogen that poses serious threats to both human and animal health. S. suis is ubiquitously transmitted from the swine industry to the environments and human communities.
Ruoyi Lv, Wenjing Zhang, Zhigang Sun, Xiaohui Si, Hong Dong, Xiaoye Liu   +5 more
doaj   +1 more source

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Rational Design, Synthesis, and Biological Evaluation of Novel Thiazole/Thiazolidinones Multitarget Anti-Human Immunodeficiency Virus Molecules

Pharmaceuticals
Background: HIV-1 RT inhibitors were the first drugs approved to treat AIDS and remain key components of highly active antiretroviral therapy (HAART). While HAART effectively suppresses viral replication and slows disease progression, it has limitations,
Christophe Tratrat, Anthi Petrou, Maria Fesatidou, Micheline Haroun, Mohamad Chohan, Athina Geronikaki   +5 more
doaj   +1 more source

Comprehensive Network Analysis Reveals the Targets and Potential Multitarget Drugs of Type 2 Diabetes Mellitus. [PDF]

Oxid Med Cell Longev, 2022
Zhou W, Liu Q, Wang W, Yuan XJ, Xiao CC, Ye SD.   +5 more
europepmc   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science
The approach to dealing with chronic wounds is still challenging in clinic. Multitarget drugs have the advantages of superior therapeutic effect and minimal adverse reactions.
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
doaj   +1 more source

Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties

Pharmaceutics
Multitarget compounds have emerged as promising drug candidates to cope with complex multifactorial diseases, like Alzheimer’s disease (AD). Most multitarget compounds are designed by linking two pharmacophores through a tether chain (linked hybrids ...
Caterina Pont, Anna Sampietro, F. Javier Pérez-Areales, Nunzia Cristiano, Agustí Albalat, Belén Pérez, Manuela Bartolini, Angela De Simone, Vincenza Andrisano, Marta Barenys, Elisabet Teixidó, Raimon Sabaté, M. Isabel Loza, José Brea, Diego Muñoz-Torrero   +14 more
doaj   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Multitarget CDK inhibitors roscovitine and UCN‑01 induce apoptosis in colorectal cancer cells by inhibiting cell cycle progression and transcription [PDF]

Brazilian Journal of Pharmaceutical Sciences
Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is steadily rising in developing nations. Cell cycle aberrations due to deregulation of cyclin dependent kinases (CDKs) and cyclins are common events ...
Sonal Mohan Manohar, Kalpana Sanjay Joshi   +1 more
doaj   +1 more source