Results 241 to 250 of about 29,139 (279)

Constitutive Activity of Muscarinic Acetylcholine Receptors

Journal of Receptors and Signal Transduction, 2006
We review the literature describing constitutive activity of the five muscarinic acetylcholine receptors in native and recombinant systems and discuss the effect of constitutive activity on muscarinic pharmacology in the context of modern models of receptor activation.
Tracy A. Spalding, Ethan S. Burstein
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Muscarinic Acetylcholine Receptors

2004
Muscarinic acetylcholine receptors are members of the G-protein-coupled receptor superfamily. There are five genes encoding the muscarinic receptors, which are expressed to different extents in a variety of tissues, including cardiac and smooth muscle, secretory glands, and neurons and glial cells in the central and peripheral nervous systems ...
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Molecular Biology of Muscarinic Acetylcholine Receptors

Critical Reviews™ in Neurobiology, 1996
Following the molecular cloning of five distinct muscarinic acetylcholine receptor (mAChR) genes, the last decade has witnessed an explosion of new knowledge about how mAChRs function at a molecular level. These studies have been greatly facilitated by the molecular characterization of the many components of the signal transduction pathways activated ...
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Immunochemical Studies of the Muscarinic Acetylcholine Receptor

Journal of Receptor Research, 1987
Muscarinic receptors have been purified from calf forebrain plasma cell membranes by affinity chromatography on a dexetimide-agarose gel. SDS-PAGE analysis showed a single 70 kDa band. Monoclonal antibodies have been prepared against these affinity purified 70 kDa protein(s).
A. Convents, S. Marulio, S. Kaveri, J Hoebeke, Arthur Donny Strosberg, M. Lauwereys, C. AndrÉ, J. O. Ouillet   +7 more
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Allosteric antagonists of the muscarinic acetylcholine receptor

Biochemical Pharmacology, 1991
For the most part, the interaction of these selective antagonists with muscarinic receptors has been interpreted in the context of simple competitive bimolecular reaction which obeys the law of mass action. In fact, the use of selective antagonists as a pharmacological tool to identify receptor types and subtypes is based on this premise.
Esam E. El-Fakahany, Norman H. Lee
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Muscarinic Acetylcholine Receptor Activators [PDF]

, 2014
Modulation of muscarinic acetylcholine receptors (mAChRs) is one of the most attractive therapeutic strategies for the treatment of schizophrenia. Pilot clinical studies of the M1/M4 mAChR-preferring agonist xanomeline as well as animal studies using M1–M5 mAChR knockout mice suggest that selective activation of M1 and/or M4 mAChRs is a key concept in ...
Takaaki Sumiyoshi, Takaaki Sumiyoshi, Takeshi Enomoto   +2 more
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Function of muscarinic and nicotinic acetylcholine receptors

Nature, 1976
ACETYLCHOLINE receptors in vertebrates can be classified in two categories—nicotinic and muscarinic—on the basis of differential sensitivity to agonist and antagonist compounds1,2. This pharmacological distinction, although useful both in therapeutics and in experimental physiology, has no known biological significance.
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Pharmacological Approaches to Targeting Muscarinic Acetylcholine Receptors

Recent Patents on CNS Drug Discovery, 2014
The presence of cholinergic system markers and muscarinic receptor subtypes in several tissues also of nonneuronal type has been largely demonstrated. Acetylcholine, synthesized in the nervous system, can locally contribute to modulate cell proliferation, survival and apoptosis. Considering that the cholinergic system functions are impaired in a number
Claudio Matera, TATA, Ada Maria
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Allosteric interactions at muscarinic acetylcholine receptors

2021
This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
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Muscarinic Acetylcholine Receptors in the Urinary Tract

2011
Muscarinic receptors comprise five cloned subtypes, encoded by five distinct genes, which correspond to pharmacologically defined receptors (M(1)-M(5)). They belong to the family of G-protein-coupled receptors and couple differentially to the G-proteins.
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