Results 241 to 250 of about 54,620 (293)

Antidepressants and the Muscarinic Acetylcholine Receptor

Archives of General Psychiatry, 1977
Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones.
S H, Snyder, H I, Yamamura
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Muscarinic acetylcholine receptors of rat lymphocytes

Biochimica et Biophysica Acta (BBA) - General Subjects, 1983
The muscarinic acetylcholine receptors on rat lymphocytes were determined by [3H]quinuclidinyl benzilate binding studies. Binding of [3H]quinuclidinyl benzilate is rapid (half saturation occurred within 120 s) and highly specific. Muscarinic receptors reveal high lability. The number of receptors on plasma membrane depends on time of incubation as well
W, Maśliński, K, Krzystyniak, E, Grabczewska, J, Ryzewski   +3 more
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Regulation of muscarinic acetylcholine receptor signaling

Pharmacology & Therapeutics, 2003
Multiple mechanisms regulate the signaling of the five members of the family of the guanine nucleotide binding protein (G protein)-coupled muscarinic acetylcholine (ACh) receptors (mAChRs). Following activation by classical or allosteric agonists, mAChRs can be phosphorylated by a variety of receptor kinases and second messenger-regulated kinases.
Chris J, van Koppen, Björn, Kaiser
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Muscarinic Acetylcholine Receptor Activators

2014
Modulation of muscarinic acetylcholine receptors (mAChRs) is one of the most attractive therapeutic strategies for the treatment of schizophrenia. Pilot clinical studies of the M1/M4 mAChR-preferring agonist xanomeline as well as animal studies using M1–M5 mAChR knockout mice suggest that selective activation of M1 and/or M4 mAChRs is a key concept in ...
Takaaki Sumiyoshi, Takeshi Enomoto
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Molecular Biology of Muscarinic Acetylcholine Receptors

Critical Reviews™ in Neurobiology, 1996
Following the molecular cloning of five distinct muscarinic acetylcholine receptor (mAChR) genes, the last decade has witnessed an explosion of new knowledge about how mAChRs function at a molecular level. These studies have been greatly facilitated by the molecular characterization of the many components of the signal transduction pathways activated ...
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Constitutive Activity of Muscarinic Acetylcholine Receptors

Journal of Receptors and Signal Transduction, 2006
We review the literature describing constitutive activity of the five muscarinic acetylcholine receptors in native and recombinant systems and discuss the effect of constitutive activity on muscarinic pharmacology in the context of modern models of receptor activation.
Tracy A, Spalding, Ethan S, Burstein
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Receptors | Muscarinic Acetylcholine Receptors

2021
Neil M. Nathanson, Justin J. Miller
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Acetylcholine: I. Muscarinic receptors

2004
The study of brain muscarinic receptors began more than a century ago, long before the existence of muscarinic receptors was postulated and then demonstrated. However, the effects of drugs acting on these receptors, such as atropine, eserine, pilocarpine and arecoline have already been studied.
PEPEU, GIANCARLO, GIOVANNINI, MARIA GRAZIA   +1 more
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