Results 91 to 100 of about 7,953 (182)

Inhaled glycopyrrolate for the treatment of chronic obstructive pulmonary disease

International Journal of COPD, 2018
Donald P Tashkin,1 Nicholas J Gross2 1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, University Medical Research LLC, Saint Francis Hospital and Medical Center, Hartford, CT, USA Abstract:
Tashkin DP, Gross NJ
doaj  

Internalization of the m2 muscarinic acetylcholine receptor. Arrestin-independent and -dependent pathways.

The Journal of biological chemistry, 1997
Recent studies have identified agonist-dependent phosphorylation as a critical event in the rapid uncoupling of the m2 muscarinic cholinergic receptors (mAChR) from G-proteins and sequestration of the receptors away from the cell surface. However, mutant m2 mAChRs were identified that were phosphorylated but unable to desensitize in adenylyl cyclase ...
R, Pals-Rylaarsdam, V V, Gurevich, K B, Lee, J A, Ptasienski, J L, Benovic, M M, Hosey   +5 more
openaire   +1 more source

Long-Acting Muscarinic Antagonists for the Treatment of Difficult-to-Treat and Severe Asthma: A Narrative Review Focusing on Inflammation from Bench to Bedside. [PDF]

J Inflamm Res
Calzetta L, Manzetti GM, Pistocchini E, Lauro RF, Gholamalishahi S, Cazzola M, Rogliani P.   +6 more
europepmc   +1 more source

Bidirectional Modulation of Beam Traversal Performance by Acetylcholine in the Cerebellar Nuclei. [PDF]

J Neurosci
Iosif CI, Drake RAR, Apps R, Bashir ZI, Pickford J.   +4 more
europepmc   +1 more source

Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction. [PDF]

Cell Commun Signal
Polishchuk A, Just-Borràs L, Cilleros-Mañé V, Balanyà-Segura M, Silvera Simón C, Tomàs M, Jami El Hirchi M, Díaz-Wallach M, Hurtado E, Tomàs J, Lanuza MA.   +10 more
europepmc   +1 more source

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy. [PDF]

ACS Chem Neurosci
Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +24 more
europepmc   +1 more source

Comprehensive perioperative management: Prevention and treatment strategies for catheter-related bladder discomfort in urological surgery patients. [PDF]

J Int Med Res
Xu W, Sun J.
europepmc   +1 more source

Peripheral Parasympathetic Networks in Pain: A Systems-Level Review of Mechanisms and Modulations. [PDF]

Cell Mol Neurobiol
Yang R, Jia S, Li Y, Yang H, Han Z, Liang L, Huang F, Fan W.   +7 more
europepmc   +1 more source

Antispasmodic Activity of Green-Synthesized Phenylaminojuglones: In Vitro and In Silico Studies. [PDF]

ACS Omega
Asunción-Alvarez D, Ybañez-Julca RO, Paredes-Doroteo GY, Quispe-Díaz IM, Mantilla-Rodríguez E, Enriquez-Lara C, Vásquez-Corales E, Buc Calderon P, Catalán MA, Gutiérrez-Alvarado WO, Benites J.   +10 more
europepmc   +1 more source

Negative Allosteric Modulation of Agonist-Induced M₂ Muscarinic Receptor/β-Arrestin Interaction by Serum Autoantibodies from Patients with Chronic Chagas Disease. [PDF]

Cells
Carrera Páez LC, Beltrame SP, Auger SR, Sabra AH, Bilder CR, Irurzun IM, Waldner CI, Goin JC.   +7 more
europepmc   +1 more source