Results 101 to 110 of about 11,132 (239)
Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells
Journal of Pharmacological Sciences, 2011 .: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada +4 more
doaj
Gut Microbes, 2020 High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in the pathogenesis of diverse metabolic and inflammatory diseases.
Lingyu Wang +11 more
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Novel long-range inhibitory nNOS-expressing hippocampal cells
eLife, 2019 The hippocampus, a brain region that is important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal ...
Zoé Christenson Wick +2 more
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Boundary lipids of the nicotinic acetylcholine receptor: spontaneous partitioning via coarse-grained molecular dynamics simulation [PDF]
arXiv, 2018 Reconstituted nicotinic acetylcholine receptors (nAChRs) exhibit significant gain-of-function upon addition of cholesterol to reconstitution mixtures, and cholesterol affects organization of nAChRs within domain-forming membranes, but whether nAChR partitions to cholesterol-rich liquid-ordered ("raft" or $l_o$) domains or cholesterol-poor liquid ...
arxiv
Frontiers in Molecular NeuroscienceFive muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao +4 more
doaj +1 more source
Japanese Journal of Pharmacology, 1989 The distribution of muscarinic acetylcholine receptors (mAChR) was investigated in the monkey brain by means of quantitative in vitro autoradiography. 3H-QNB, 3H-pirenzepine (PZ) and 3H-AF-DX 116 were used for labelling total mAChR, M1 and M2 receptors, respectively. 3H-PZ and 3H-AF-DX 116 showed specificity to each receptor subtype in the monkey brain.
Shozo Kito +2 more
openaire +3 more sources
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics [PDF]
Journal of Computational Neuroscience 24, 253-276 (2008), 2007 To establish the relationship between locomotory behavior and dynamics of neural circuits in the nematode C. elegans we combined molecular and theoretical approaches. In particular, we quantitatively analyzed the motion of C. elegans with defective synaptic GABA and acetylcholine transmission, defective muscle calcium signaling, and defective muscles ...
arxiv
Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice
Neurobiology of Disease, 2006 In 7-month-old TgCRND8 mice, the extracellular cortical acetylcholine levels in vivo, the number and morphology of cholinergic neurons in the nucleus basalis magnocellularis and the ability to acquire an inhibitory avoidance response in the step-down ...
Arianna Bellucci +6 more
doaj
The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]
arXiv, 2011 The surface accessibility of {\alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {\alpha}-bungarotoxin C{\alpha}H peaks of 1H-13C HSQC spectra have been analyzed and compared with the ones previously obtained in the presence of GdDTPA-BMA. In spite of the different
arxiv
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]
arXiv, 2017 We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration, and effective Hill coefficient, and explore the full spectrum
arxiv