Results 151 to 160 of about 7,953 (182)
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Human skin fibroblasts express m2, m4, and m5 subtypes of muscarinic acetylcholine receptors
Journal of Cellular Biochemistry, 1999Previous studies have demonstrated that muscarinic acetylcholine receptors (mAChRs) are expressed by human skin fibroblasts (HSF). We have identified the molecular subtypes of these receptors by reverse transcription-polymerase chain reaction (RT-PCR), using m1-m5 subtype-specific primers.
R, Buchli +5 more
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Nature of the oligomers formed by muscarinic m2 acetylcholine receptors in Sf9 cells
European Journal of Pharmacology, 2001Wild-type, FLAG-tagged, and c-myc-tagged muscarinic m2 receptors extracted in digitonin-cholate from singly and co-infected Sf9 (Spodoptera frugiperda) cells were indistinguishable in their binding of [3H]quinuclidinylbenzilate, either before or after purification.
P, Park +4 more
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Effects of Autoantibodies against M2 Muscarinic Acetylcholine Receptors on Rabbit Atria in vivo
Cardiology, 2008<i>Background:</i> Evidence has shown that autoantibodies against M2 muscarinic acetylcholine receptors may play a role in the development of atrial fibrillation. The goal of this study was to evaluate the effects of anti-M2 receptor autoantibodies on rabbit atria in vivo.
Chang Ming, Hong +5 more
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Bioscience Hypotheses, 2008
Abstract Atrial fibrillation is a major and growing public health problem in the world. Heart failure is one of the most common clinical settings for chronic AF. The mechanism underlying AF is still not fully understood. Increasing evidence suggests that activation of G-protein-coupled receptors by autoantibodies may contribute to the pathophysiology
Chang-Ming Hong +2 more
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Abstract Atrial fibrillation is a major and growing public health problem in the world. Heart failure is one of the most common clinical settings for chronic AF. The mechanism underlying AF is still not fully understood. Increasing evidence suggests that activation of G-protein-coupled receptors by autoantibodies may contribute to the pathophysiology
Chang-Ming Hong +2 more
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Characterisation of M2 muscarinic acetylcholine receptor signalling in dental pulp stem cells
2023Cholinergic signalling is hypothesised to occur in stem cells, and there is evidence that mesenchymal stem cells (MSCs) express a functional cholinergic system. Expression of functional acetylcholine receptors (AChRs) have been reported in several types of MSC, which suggests that MSCs have non-neuronal cholinoceptive properties that may play a role in
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Molecular and Cellular Neuroscience, 1991
We have recently shown that colchicine induces a time-and dose-dependent decrease of m3-muscarinic acetylcholine receptor (mAChR) mRNA in rat cerebellar granule cells (F. Fukamauchi, C. Hough, and D.-M. Chuang, 1991, Mol. Cell. Neurosci. 2: 123-129).
F, Fukamauchi, C, Hough, D M, Chuang
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We have recently shown that colchicine induces a time-and dose-dependent decrease of m3-muscarinic acetylcholine receptor (mAChR) mRNA in rat cerebellar granule cells (F. Fukamauchi, C. Hough, and D.-M. Chuang, 1991, Mol. Cell. Neurosci. 2: 123-129).
F, Fukamauchi, C, Hough, D M, Chuang
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
exaly
Visualizing the M2 muscarinic acetylcholine receptor activation regulated by aromatic ring dynamics
A detailed molecular understanding of the G-protein coupled receptor (GPCR) activation mechanism is crucial for rational drug design. Despite the growing number of GPCR structures being resolved in the inactive and activated states, the detailed molecular mechanism of how receptors transits from the inactive towards the active one upon agonist binding ...Zhou Gong +4 more
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