Results 61 to 70 of about 30,424 (296)

Ligand Binding-Induced Structural Changes in the M2 Muscarinic Acetylcholine Receptor Revealed by Vibrational Spectroscopy.

Journal of Physical Chemistry Letters, 2019
M2 muscarinic acetylcholine receptor (M2R) is a prototypical G protein-coupled receptor (GPCR) that responds to acetylcholine and mediates various cellular responses in the nervous system.
K. Katayama, Kohei Suzuki, Ryoji Suno, Hirokazu Tsujimoto, S. Iwata, Takuya Kobayashi, H. Kandori   +6 more
semanticscholar   +1 more source

Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey

Frontiers in Neural Circuits, 2022
Acetylcholine (ACh) can act on pre- and post-synaptic muscarinic receptors (mAChR) in the cortex to influence a myriad of cognitive processes. Two functionally-distinct regions of the prefrontal cortex—the lateral prefrontal cortex (LPFC) and the ...
Alexandra Tsolias, Maria Medalla
semanticscholar   +1 more source

Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor

Molecular Pharmacology, 2023
The development of subtype selective small molecule drugs for the muscarinic acetylcholine receptor (mAChR) family has been challenging. The design of more selective ligands can be improved by understanding the structure and function of key amino acid residues that line ligand binding sites.
Vi Pham, Maria Clazina Cornelia Habben Jansen, Geoff Thompson, Laura H. Heitman, Arthur Christopoulos, David M. Thal, Celine Valant   +6 more
openaire   +3 more sources

Molecular Biological Mechanisms of Yuan Zhi Powder in the Treatment of Alzheimer’s Disease: an Analysis Based on Network Pharmacology

Digital Chinese Medicine, 2018
: Objective To predict the main active ingredients, potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by ...
Wei-Jie Qiang, Ying Chen, Fu-Yuan He, Mei-Feng Xiao, Wei-Yan Cai, Yi-Fei Dai, Qing Yang, Yu-Jie Li, Xiao-Gang Weng, Qi Li, Ya-Jie Wang, Xiao-Xin Zhu   +11 more
doaj   +1 more source

An in vivo biosensor for neurotransmitter release and in situ receptor activity. [PDF]

, 2010
Tools from molecular biology, combined with in vivo optical imaging techniques, provide new mechanisms for noninvasively observing brain processes. Current approaches primarily probe cell-based variables, such as cytosolic calcium or membrane potential ...
Griesbeck, Oliver, Kleinfeld, David, Mank, Marco, Muller, Arnaud, Nguyen, Quoc-Thang, Schroeder, Lee F, Taylor, Palmer   +6 more
core   +2 more sources

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

M2-AChR Mediates Rapid Antidepressant Effects of Scopolamine Through Activating the mTORC1-BDNF Signaling Pathway in the Medial Prefrontal Cortex

Frontiers in Psychiatry, 2021
Background: Scopolamine, a non-selective muscarinic acetylcholine receptor (M1~5-AChR) antagonist, has rapid and robust antidepressant effects in humans and other species. However, which of the five M-AChRs mediates these therapeutic effects has not been
Shuang Liu, Dandan Shi, Zuoli Sun, Yi He, Jian Yang, Jian Yang, Gang Wang, Gang Wang   +7 more
doaj   +1 more source

Muscarinic receptor oligomerization [PDF]

, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins.
Alvarez-Curto, Elisa, Marsango, Sara, Milligan, Graeme, Ward, Richard J.   +3 more
core   +1 more source

Enteric dysfunctions in experimental Parkinson's disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats [PDF]

, 2016
Parkinson's disease (PD) is frequently associated with gastrointestinal symptoms, mostly represented by constipation and defecatory dysfunctions.
Al Harraq, Zainab, Antonioli, Luca, Ballabeni, Vigilio, Barocelli, Elisabetta, Bernardini, Nunzia, Blandini, Fabio, Blandizzi, Corrado, Cerri, Silvia, Colucci, ROCCHINA LUCIA, Fornai, Matteo, Ippolito, Chiara, Levandis, Giovanna, Pellegrini, Carolina, Segnani, Cristina, Vegezzi, Gaia   +14 more
core   +1 more source

Dual p38/JNK mitogen activated protein kinase inhibitors prevent ozone-induced airway hyperreactivity in guinea pigs. [PDF]

PLoS ONE, 2013
Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonary complications. Ozone reacts with the epithelial lining fluid and airway epithelium to produce reactive oxygen species and lipid peroxidation products ...
Kirsten C Verhein, Francesco G Salituro, Mark W Ledeboer, Allison D Fryer, David B Jacoby   +4 more
doaj   +1 more source