Results 61 to 70 of about 7,912 (220)

The structure of the third intracellular loop of the muscarinic acetylcholine receptor M₂ subtype [PDF]

FEBS Letters, 2005
We have examined whether the long third intracellular loop (i3) of the muscarinic acetylcholine receptor M2 subtype has a rigid structure. Circular dichroism (CD) and nuclear magnetic resonance spectra of M2i3 expressed in and purified from Escherichia coli indicated that M2i3 consists mostly of random coil.
Ichlyama, S, Oka, Y, Haga, K, Kojima, S, Tateishi, Y, Shirakawa, M, Haga, T   +6 more
openaire   +2 more sources

Mechanisms of Pilocarpine‐Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Pilocarpine activates M1 and M3 muscarinic receptors in porcine ciliary muscle, engaging calcium‐dependent phospholipase C (PLC), nitric oxide synthase (NOS), and cyclooxygenase (COX) pathways that increase prostaglandin E2 (PGE2) synthesis. Beyond nitric oxide (NO) modulation, PGE2 emerges as a key mediator linking muscarinic signaling to ciliary ...
Giovanna Benozzi, Emmanuel Quinteros Villarruel, Andrés F. Zuluaga, Betina Orman   +3 more
wiley   +1 more source

Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction

Acta Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the primary cause of death in opioid overdose, resulting from both suppressed respiratory rhythm and increased airway and thoracic rigidity that compromise ventilation and resuscitation. While the effect(s) of opioids on central rhythm‐generating circuits are well documented, the mechanisms ...
Riley R. Parks, Marissa J. Andersen, Mackenna L. Hatfield, Nicholas J. Burgraff   +3 more
wiley   +1 more source

Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic Interneurons

Frontiers in Cellular Neuroscience, 2016
The striatum is the most prominent nucleus in the basal ganglia and plays an important role in motor movement regulation. The cholinergic interneurons (ChIs) in striatum are involved in the motion regulation by releasing acetylcholine (ACh) and ...
Zhe eZhao, Kang eZhang, Xiaoyan eLiu, Haitao eYan, Xiaoyun eMa, Shuzhuo eZhang, Jianquan eZheng, Liyun eWang, Xiaoli eWei   +8 more
doaj   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

The Role of Voltage-Gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: Evidence From a Retrospective Clinical Study and Mouse Model

Frontiers in Pharmacology, 2020
Atropine is commonly used to counter the effects of the parasympathetic neurotransmitter acetylcholine on heart rate in clinical practice, such as in the perioperative period; however, individual differences in the response to atropine are huge.
Baowen Liu, Baowen Liu, Ningbo Li, Jin Zhang, Yi Liu, Mi Zhang, Yishun Hong, Wenyao Wu, Xianwei Zhang, Guangyou Duan   +9 more
doaj   +1 more source

Evaluation of the Efficacy of Metformin in the Treatment of Acne Vulgaris and Its Effects on Serum Lipid Metabolism

Journal of Cosmetic Dermatology, Volume 24, Issue 10, October 2025.
ABSTRACT Background Acne vulgaris (AV) is a common inflammatory skin disease during adolescence. Metformin (MET) has recently been found to have the effects of regulating lipid disorders, suggesting its potential benefits in the treatment of AV patients. Method Recruited 18 patients with moderate to severe AV, and then received MET treatment (AVM group)
Jie Hu, Yuxin He, Peiyang Du, Yongqiong Deng, Xia Xiong, Yaxin Huang   +5 more
wiley   +1 more source

Muscarinic acetylcholine receptors M2 are upregulated in the atrioventricular nodal tract in horses with a high burden of second-degree atrioventricular block

Frontiers in Cardiovascular Medicine, 2023
BackgroundSecond-degree atrioventricular (AV) block at rest is very common in horses. The underlying molecular mechanisms are unexplored, but commonly attributed to high vagal tone.AimTo assess whether AV block in horses is due to altered expression of ...
Sarah Dalgas Nissen, Arnela Saljic, Arnela Saljic, Helena Carstensen, Thomas Hartig Braunstein, Eva Melis Hesselkilde, Sofie Troest Kjeldsen, Charlotte Hopster-Iversen, Alicia D’Souza, Thomas Jespersen, Rikke Buhl   +10 more
doaj   +1 more source

Tumor‐Associated Sympathetic Nerves Promote the Progression of Epstein‐Barr Virus‐Positive Diffuse Large B‐Cell Lymphoma

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Sympathetic nerve innervation promotes the progression of Epstein‐Barr virus‐positive diffuse large B‐cell lymphoma (EBV+ DLBCL) via β2‐adrenergic receptors. The discovery of enhanced nerve infiltration and β2AR expression reveals a novel mechanism and highlights the sympathetic–β2AR axis as a promising target for therapeutic intervention in EBV+ DLBCL.
Silan Huang, Dexin Lei, Linbin Yang, Aiwei Bi, Yanlou Wang, Peng Zhang, Dongyu Zhuang, Honglian Liu, Qingqing Cai, Man Nie, Yi Xia   +10 more
wiley   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, Volume 3, Issue 3, September 2025.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source