Results 71 to 80 of about 15,825 (259)

Influence of nano-TiO2 on functioning of gastric smooth muscles: in vitro and in silico studies

Біологічні студії, 2019
Nanosized materials, including titanium dioxide nanoparticles, sized under 10 nm, are systems with an excessive energy and high chemical activity, while the nanopartic­les of about (1–3) nm enter the reactions with other chemical compounds practically ...
O. V. Tsymbalyuk, A. M. Naumenko, T. L. Davydovska   +2 more
doaj   +1 more source

Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy

Biomedicines, 2020
Experimental and clinical studies of cardiac pathology associated with epilepsy have demonstrated an impact on the autonomic nervous system (ANS). However, the underlying molecular mechanism has not been fully elucidated.
Enes Akyüz, Züleyha Doğanyiğit, Yam Nath Paudel, Emin Kaymak, Seher Yilmaz, Arda Uner, Mohd. Farooq Shaikh   +6 more
doaj   +1 more source

Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function

Hippocampus, Volume 35, Issue 5, September 2025.
ABSTRACT The dorsal and ventral hippocampus have distinct processing properties, but it remains unclear if interneuron subtypes differ in connectivity along the dorsoventral axis. Oriens lacunosum‐moleculare (OLM) interneurons, identified by the Chrna2 gene, are known to regulate memory processes differently along this axis. OLMɑ2 cells bidirectionally
Angelica Thulin, Katharina Henriksson, Ingrid Nogueira, Klas Kullander   +3 more
wiley   +1 more source

Presynaptic M1 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in the hippocampus in vitro [PDF]

, 1990
The effects of the cholinoceptor agonist, carbachol (CCh), were examined in the rat hippocampal slice preparation. Intracellular recordings from CA1 pyramidal neurones revealed that CCh (1–3 μM) inhibited excitatory postsynaptic responses evoked by ...
Sheridan, Robert D., Sutor, Bernd
core   +1 more source

Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery

JOR SPINE, Volume 8, Issue 3, September 2025.
This study explores the role of Central Pattern Generators (CPGs) in locomotor recovery after spinal cord injury (SCI). It examines CPG organization, function, and modulation through amino acids, biogenic amines, and acetylcholine. Therapeutic strategies, including pharmacological, electrical, and optogenetic approaches, are reviewed, alongside current
Hao Su, Longfei Jing, Dongmei Lv, Zhendong Huan, Wenqiang Xu   +4 more
wiley   +1 more source

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj  

Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium

Autoimmunity, 2018
Autoantibodies against the M2 subtype of muscarinic acetylcholine receptors with functional activities have been found in the sera of patients with dilated cardiomyopathy (DCM), and the second extracellular loop has been established as the predominant ...
Karla Consort Ribeiro, Roberto Perez Campelo, Daniela del Rosário Flores Rodrigues, Elisabete C. Mattos, Izaira Trincani Brandão, Célio Lopes da Silva, Eliete Bouskela, Camila Guerra Martinez, Eleonora Kurtenbach   +8 more
doaj   +1 more source

Effects of Icariin and Its Metabolites on GPCR Regulation and MK-801-Induced Schizophrenia-Like Behaviors in Mice

Molecules, 2023
Icariin, a major bioactive compound found in the Epimedium genus, has been reported to exert protective effects against neurodegenerative disorders. In the current study, we aimed to investigate the regulatory effect of icariin and its active metabolites
Su Hui Seong, Seo Hyun Kim, Jong Hoon Ryu, Jin-Woo Jeong, Hyun Ah Jung, Jae Sue Choi   +5 more
doaj   +1 more source

β3‐Adrenoceptor Agonist Effects on the Urinary Bladder Beyond Detrusor Relaxation

Neurourology and Urodynamics, Volume 44, Issue 7, Page 1498-1502, September 2025.
ABSTRACT Aims β3‐Adrenoceptor agonists such as mirabegron or vibegron reach pharmacokinetic steady‐state within a few days. However, maximum improvements in symptoms of the overactive bladder syndrome are reached at time points later than 4 weeks, that is, detrusor smooth muscle relaxation cannot fully explain clinical effects.
Martin C. Michel, Ebru Arioglu‐Inan, Martin Hennenberg   +2 more
wiley   +1 more source

The structure of the third intracellular loop of the muscarinic acetylcholine receptor M₂ subtype [PDF]

FEBS Letters, 2005
We have examined whether the long third intracellular loop (i3) of the muscarinic acetylcholine receptor M2 subtype has a rigid structure. Circular dichroism (CD) and nuclear magnetic resonance spectra of M2i3 expressed in and purified from Escherichia coli indicated that M2i3 consists mostly of random coil.
Ichlyama, S, Oka, Y, Haga, K, Kojima, S, Tateishi, Y, Shirakawa, M, Haga, T   +6 more
openaire   +2 more sources