Results 81 to 90 of about 7,912 (220)

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, Volume 12, Issue 31, August 21, 2025.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation

Gut Microbes, 2020
High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in the pathogenesis of diverse metabolic and inflammatory diseases.
Lingyu Wang, Zizhen Gong, Xiuyuan Zhang, Fangxinxing Zhu, Yuchen Liu, Chaozhi Jin, Xixi Du, Congfeng Xu, Yingwei Chen, Wei Cai, Chunyan Tian, Jin Wu   +11 more
doaj   +1 more source

Effects of Autoantibodies against M2 Muscarinic Acetylcholine Receptors on Rabbit Atria in vivo

Cardiology, 2008
<i>Background:</i> Evidence has shown that autoantibodies against M2 muscarinic acetylcholine receptors may play a role in the development of atrial fibrillation. The goal of this study was to evaluate the effects of anti-M2 receptor autoantibodies on rabbit atria in vivo.
Fu Jun Shang, Xiong Tao Liu, Wen Rui Jiang, Chang Ming Hong, Qiangsun Zheng, Hongtao Wang   +5 more
openaire   +2 more sources

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

Novel long-range inhibitory nNOS-expressing hippocampal cells

eLife, 2019
The hippocampus, a brain region that is important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal ...
Zoé Christenson Wick, Madison R Tetzlaff, Esther Krook-Magnuson   +2 more
doaj   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Quantitative Autoradiographic Localization of the M1 and M2 Subtypes of Muscarinic Acetylcholine Receptors in the Monkey Brain

Japanese Journal of Pharmacology, 1989
The distribution of muscarinic acetylcholine receptors (mAChR) was investigated in the monkey brain by means of quantitative in vitro autoradiography. 3H-QNB, 3H-pirenzepine (PZ) and 3H-AF-DX 116 were used for labelling total mAChR, M1 and M2 receptors, respectively. 3H-PZ and 3H-AF-DX 116 showed specificity to each receptor subtype in the monkey brain.
Shozo Kito, Rie Miyoshi, Masanori Shimoyama   +2 more
openaire   +3 more sources

Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias [PDF]

, 2010
Karen J. Gregory, Nathan E. Hall, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos   +4 more
openalex   +1 more source

Modular horizontal network within mouse primary visual cortex

Frontiers in Neuroanatomy
Interactions between feedback connections from higher cortical areas and local horizontal connections within primary visual cortex (V1) were shown to play a role in contextual processing in different behavioral states.
Andreas Burkhalter, Weiqing Ji, Andrew M. Meier, Andrew M. Meier, Rinaldo D. D’Souza   +4 more
doaj   +1 more source

Desensitization and Sequestration of Human m2 Muscarinic Acetylcholine Receptors by Autoantibodies from Patients with Chagas' Disease [PDF]

, 1997
Claudia Pérez Leirós, Leonor Sterin‐Borda, Enri Borda, Juan Carlos Goin, M. Marlene Hosey   +4 more
openalex   +1 more source