Results 81 to 90 of about 11,132 (239)

Simultaneous Modeling of In Vivo and In Vitro Effects of Nondepolarizing Neuromuscular Blocking Drugs [PDF]

arXiv, 2023
Nondepolarizing neuromuscular blocking drugs (NDNBs) are clinically used to produce muscle relaxation during general anesthesia. This paper explores a suitable model structure to simultaneously describe in vivo and in vitro effects of three clinically used NDNBs, cisatracurium, vecuronium, and rocuronium. In particular, it is discussed how to reconcile
arxiv  

Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats

Scientific Reports, 2017
The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells.
Marzia Soligo, Sonia Piccinin, Virginia Protto, Francesca Gelfo, Maria Egle De Stefano, Fulvio Florenzano, Erica Berretta, Laura Petrosini, Robert Nisticò, Luigi Manni   +9 more
doaj   +1 more source

Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]

arXiv, 2009
To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv  

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats

British Journal of Pharmacology, Volume 182, Issue 11, Page 2487-2502, June 2025.
Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract to be questioned.
Sara Traserra, Terence Appelqvist, Robert Lange, Maura Corsetti, Marcel Jimenez   +4 more
wiley   +1 more source

Enhanced Conformational Sampling of M2 Muscarinic Acetylcholine Receptor for Designing Selective Allosteric Drugs [PDF]

Biophysical Journal, 2013
Muscarinic acetylcholine receptors are members of the superfamily of G-protein coupled receptors (GPCRs) and play critical roles in both the central and parasympathetic nervous systems. They are important drug targets for the treatment of a spectrum of diseases including abnormal heart rate, asthma, chronic obstructive pulmonary disease, Alzheimer's ...
J. Andrew McCammon, J. Andrew McCammon, Yinglong Miao   +2 more
openaire   +2 more sources

PET mapping of receptor occupancy using joint direct parametric reconstruction [PDF]

Receptor occupancy (RO) studies using PET neuroimaging play a critical role in the development of drugs targeting the central nervous system (CNS). The conventional approach to estimate drug receptor occupancy consists in estimation of binding potential changes between two PET scans (baseline and post-drug injection).
arxiv   +1 more source

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases

Orthopaedic Surgery, Volume 17, Issue 6, Page 1561-1576, June 2025.
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Ruihao Xia, Hongjun Peng, Xishan Zhu, Wangdui Suolang, Steve T. L. Pambayi, Xiao Yang, Yi Zeng, Bin Shen   +7 more
wiley   +1 more source

Binding and functional characterisation of allosteric agonists at M2 muscarinic acetylcholine receptors

The FASEB Journal, 2008
Muscarinic acetylcholine receptors (mAChRs) contain at least one allosteric site that is topographically distinct from the acetylcholine (ACh)‐binding orthosteric site. Although numerous studies have investigated the structural basis of allosteric modulation at these receptors, far less is known about allosteric ligands that activate the receptor in ...
Nathan E. Hall, Patrick M. Sexton, Arthur Christopoulos, Karen J. Gregory   +3 more
openaire   +2 more sources

Sex and age differences in the association between heart rate variability and cardiac chronotropy: A replication‐extension study

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract Using heart rate variability (vmHRV) as a proxy of cardiac vagal modulation, previous studies have hinted at sex differences in the vagal control of cardiac chronotropy in young adults, but little is known in older individuals. The current study aimed at investigating for the first time the moderating role of both sex and age in the ...
Luca Carnevali, Darcianne K. Watanabe, Margherita Barbetti, Suzi Hong, DeWayne P. Williams, Jordan Kohn, Julian Koenig, Julian F. Thayer   +7 more
wiley   +1 more source

Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability [PDF]

arXiv, 2017
Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle tracking, mean-squared displacement (MSD), turning angle, ergodicity, and clustering analyses to ...
arxiv