Results 81 to 90 of about 16,354 (156)

The Role of Voltage-Gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: Evidence From a Retrospective Clinical Study and Mouse Model

Frontiers in Pharmacology, 2020
Atropine is commonly used to counter the effects of the parasympathetic neurotransmitter acetylcholine on heart rate in clinical practice, such as in the perioperative period; however, individual differences in the response to atropine are huge.
Baowen Liu, Baowen Liu, Ningbo Li, Jin Zhang, Yi Liu, Mi Zhang, Yishun Hong, Wenyao Wu, Xianwei Zhang, Guangyou Duan   +9 more
doaj   +1 more source

Donepezil‐Induced Severe Anorexia and T‐Wave Inversion in Early‐Onset Alzheimer's Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Donepezil hydrochloride, used to treat Alzheimer's disease, is typically initiated at a low dose and titrated to minimize gastrointestinal side effects. Despite its favorable safety profile, the patient developed severe anorexia, dehydration, and electrocardiographic abnormalities.
Nobuyuki Takahashi, Takeshi Kuroda, Takashi Yoshioka, Hidetomo Murakami, Hironori Tanaka   +4 more
wiley   +1 more source

Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina

Heliyon
The turnover rate of melanogenesis in retinal pigment epithelium (RPE) and its molecular signaling remain unclear. This study aimed to investigate the role of cholinergic signaling in the process of melanogenesis of cultured RPE cells.
Ivan Kong, Gary Ka-Wing Yuen, Qi-Yun Wu, Maggie Sui-Sui Guo, Jin Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsim   +6 more
doaj   +1 more source

Effect of Anticholinergic Drug Burden on Postoperative Delirium in Elderly Patients: A Nested Case–Control Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This nested cohort study, nested within a multicentre prospective dataset of 6421 elective non‐cardiac surgery patients aged ≥ 65 years, tested whether pre‐operative anticholinergic burden predicts incident post‐operative delirium. Multivariable conditional logistic regression analysis revealed that each 1‐point increment in the Anticholinergic ...
Ting Zhang, Tianqi Shen, Ningxin Li, Xiaoying Zhang, Kai Zhang, Chang Liu, Bingbing Meng, Shaohua Zhang, Guangyu Tang, Ziyi Zhang, Qiang Fu, Yanhong Liu, Jingsheng Lou, Jiangbei Cao, Weidong Mi, Hao Li   +15 more
wiley   +1 more source

Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs [PDF]

, 2016
Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown.
Godin, Antoine G., Marsango, Sara, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +4 more
core   +1 more source

Edible Seeds in the Fight Against Hypertension: A Review of In Vitro, In Vivo, and Clinical Evidences With a Mechanistic Insight of Bioactive Compounds

Food Frontiers, Volume 7, Issue 1, January 2026.
The presented review provides the potential antihypertensive benefits of traditionally employed edible seeds, presenting new perspectives and avenues for future research. ABSTRACT Hypertension, often referred to as a silent killer, is responsible for 7.5 million deaths, representing approximately 12.8% of all global mortality.
Jinmin Shi, Mohamad Fawzi Mahomoodally, Ahmed Abduljalal Abduljabbar, Ruttun Bushra Umme Zainab, Katharigatta N. Venugopala, Gokhan Zengin, Sakina Yagi, Meng‐Yao Li, Xuebo Hu   +8 more
wiley   +1 more source

Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]

, 2018
Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +3 more
core   +1 more source

A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]

, 2017
The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Marsango, Sara, Millan, Mark J., Milligan, Graeme, Pediani, John D., Ward, Richard J.   +6 more
core   +2 more sources

Vitamin C Alleviates Oxidative Stress in Silver Carp (Hypophthalmichthys molitrix) Fingerlings Exposed to Toxicity Induced by Temephos and Buprofezin

Aquaculture Research, Volume 2026, Issue 1, 2026.
Context Organophosphates and chitin synthesis inhibitor pesticides pose a significant indirect threat to fish populations, necessitating effective remedial measures. Objective Supplementation with vitamin C (Vit C) in fish feed as a counteracting strategy to mitigate pesticides effect was explored in silver carp (Hypophthalmichthys molitrix ...
Sumaira Hassan, Irfan Zia Qureshi, Modhi O. Alotaibi, Mitesh Patel, Mohd Adnan, Nawaf Alshammari, Shakira Ghazanfar   +6 more
wiley   +1 more source

Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]

, 2009
We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros, Cho, D. A. Dougherty, Dougherty, Dougherty, Dougherty, Doupnik, Gallivan, H. A. Lester, Hibert, Hopkins, Huang, Huang, K. S. Bower, Klabunde, Kofuji, Krapivinsky, Lagerstrom, Lu, Lu, M. M. Torrice, Ma, Mark, Nemeth, Nowak, Palczewski, Rasmussen, Schwartz, Warne, Xiu, Zacharias, Zhong   +31 more
core   +3 more sources