Results 81 to 90 of about 7,953 (182)

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
Robin Pals-Rylaarsdam, Vsevolod V. Gurevich, Katharine B. Lee, Judith A. Ptasienski, Jeffrey L. Benovic, M. Marlene Hosey   +5 more
openaire   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Binding and functional characterisation of allosteric agonists at M2 muscarinic acetylcholine receptors

The FASEB Journal, 2008
Muscarinic acetylcholine receptors (mAChRs) contain at least one allosteric site that is topographically distinct from the acetylcholine (ACh)‐binding orthosteric site. Although numerous studies have investigated the structural basis of allosteric modulation at these receptors, far less is known about allosteric ligands that ...
Karen Joan Gregory, Nathan E. Hall, Patrick M. Sexton, Arthur Christopoulos   +3 more
openaire   +1 more source

Exploring functional motions of muscarinic acetylcholine M2 receptor

, 2020
G-protein bağlı reseptörler (GPRs) en büyük sinyal protein ailesidir ve bu yüzden işleyiş mekanızmalarının altında yatan dinamik etkenlerin anlaşılması ilaç tasarımında büyük bir öneme sahiptir. Bu güne kadar yapılan pek çok çalışma olmasına rağmen, inaktif ve aktif yapılar arasında gerçekleşen kolektif konformasyonel değişimlerin özellikleri ve ...
openaire   +1 more source

Modular horizontal network within mouse primary visual cortex

Frontiers in Neuroanatomy
Interactions between feedback connections from higher cortical areas and local horizontal connections within primary visual cortex (V1) were shown to play a role in contextual processing in different behavioral states.
Andreas Burkhalter, Weiqing Ji, Andrew M. Meier, Andrew M. Meier, Rinaldo D. D’Souza   +4 more
doaj   +1 more source

Muscarinic acetylcholine receptor M2 (CHRM2; HM2) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks

Pharmaceutical Science Advances
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs ...
Md. Elit Rahman, Md. Anisur Rahman, Salehin Sheikh, Md. Jannatul Islam Polash, Sozoni Khatun, Mst. Sonia Akter Bristi, Md. Showkoth Akbor, Mst. Farjanamul Haque, Mehedi Hasan Bappi, Tohidul Islam Tanim, Siddique Akber Ansari, Irfan Aamer Ansari, Elaine Cristina Pereira Lucetti, Carolina Bandeira Domiciano, Henrique D.M. Coutinho, Muhammad Torequl Islam   +15 more
doaj   +1 more source

Internalization and Down-regulation of Human Muscarinic Acetylcholine Receptor m2 Subtypes [PDF]

Journal of Biological Chemistry, 1998
Hirofumi Tsuga, Kimihiko Kameyama, Tatsuya Haga, Takeshi Honma, Jelveh Lameh, Wolfgang Sadée   +5 more
openaire   +1 more source

Noninvasive cardiac modulation via triplet-sensitized photoswitching in the phototherapeutic window

Nature Communications
Red, far red, or near-infrared photoswitchable drugs offer immense photo-pharmacological advantages due to the higher light penetration through the skin.
Lukas Naimovičius, Mila Miroshnichenko, Ekin Opar, Helen Hölzel, Masa-aki Morikawa, Nobuo Kimizuka, Manvydas Dapkevičius, Justas Lekavičius, Edvinas Radiunas, Karolis Kazlauskas, Víctor Cilleros-Mañé, Fabio Riefolo, Carlo Matera, Kevser Harmandar, Masahiko Taniguchi, Fabienne Dumoulin, Jonathan S. Lindsey, Pankaj Bharmoria, Pau Gorostiza, Kasper Moth-Poulsen   +19 more
doaj   +1 more source

Acetylcholinesterase (AChE); muscarinic acetylcholine receptor M2 (CHRM2; HM2) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source