Results 1 to 10 of about 5,131 (212)

Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell-cell junctions. [PDF]

Reproduction, 2021
Muscarinic acetylcholine receptor (mAChR) antagonists have been reported to decrease male fertility; however, the roles of mAChRs in spermatogenesis and the underlying mechanisms are not understood yet. During spermatogenesis, extensive remodeling between Sertoli cells and/or germ cells interfaces takes place to accommodate the transport of developing ...
Han X, Zhang C, Ma X, Yan X, Xiong B, Shen W, Yin S, Zhang H, Sun Q, Zhao Y.   +9 more
europepmc   +5 more sources

Molecular Conversion of Muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin 7 (MT7)-Binding Protein [PDF]

Toxins, 2011
Muscarinic toxin 7 (MT7) is a mamba venom peptide that binds selectively to the M1 muscarinic acetylcholine receptor. We have previously shown that the second (ECL2) and third (ECL3) extracellular loops of the M1 receptor are critically involved in ...
Katja Näreoja, Johnny Näsman, Sergio Rondinelli   +2 more
doaj   +6 more sources

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice

Neurobiology of Disease, 2006
The M5 muscarinic acetylcholine receptor (M5R) has been shown to play a crucial role in mediating acetylcholine-dependent dilation of cerebral blood vessels.
Runa Araya, Takanori Noguchi, Munehiro Yuhki, Naohito Kitamura, Makoto Higuchi, Takaomi C. Saido, Kenjiro Seki, Shigeyoshi Itohara, Masako Kawano, Kentaro Tanemura, Akihiko Takashima, Kazuyuki Yamada, Yasushi Kondoh, Iwao Kanno, Jürgen Wess, Masahisa Yamada   +15 more
doaj   +5 more sources

Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis [PDF]

Medical Science Monitor, 2014
Cholinergic signaling via muscarinic acetylcholine receptors (mAChR) is known to influence various physiological functions. In bone, M3 mAChR and M5 mAChR were identified on the membrane of osteoblast-like cells. M3 mAChR seems to be particularly relevant for bone physiology, as signaling via this receptor was reported to increase bone formation and ...
Reinhard Schnettler
openalex   +4 more sources

Muscarinic Acetylcholine Receptor M5 Involved in Spermatogenesis through the Modification of Cell-Cell Junctions [PDF]

, 2020
Abstract The authors have withdrawn this preprint due to author disagreement.
Yong Zhao, Xiao Han, Pengfei Zhang, Wei Shen, Hongfu Zhang, Cong Zhang, Bohui Xiong, Shen Yin, Zhao‐Jia Ge   +8 more
  +5 more sources

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR [PDF]

Nature Communications
The M5 muscarinic acetylcholine receptor (M5 mAChR) represents a promising therapeutic target for neurological disorders. However, the high conservation of its orthosteric binding site poses significant challenges for drug development.
Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal   +13 more
doaj   +2 more sources

Isolation and Functional Characterization of the Chick M5 Muscarinic Acetylcholine Receptor Gene [PDF]

Journal of Neurochemistry, 2000
Abstract: The chick is a widely used system for study of the actions of muscarinic acetylcholine receptors in the cardiovascular, visual, and nervous systems. We report the isolation and functional analysis of the gene encoding the chick M5 muscarinic receptor.
Sharon A. Creason, Kathleen M. Tietje, Neil M. Nathanson   +2 more
openalex   +4 more sources

Cellular responses to stimulation of the M5 muscarinic acetylcholine receptor as seen in murine L cells.

Journal of Biological Chemistry, 1990
The membrane signaling properties of the neuronal type-5 muscarinic acetylcholine receptor (M5 AChR) as expressed in murine L cells were studied. Recipient Ltk- cells responded to ATP acting through a P2-purinergic receptor by increasing phosphoinositide hydrolysis 2-fold but were unresponsive to 17 receptor agonists that are stimulatory in other cells.
C F Liao, William P. Schilling, M Birnbaumer, Lutz Birnbaumer   +3 more
openalex   +4 more sources

All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium [PDF]

Scientific Reports, 2017
AbstractClinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microvascular tissue, a subtype functional characterization in mouse brain endothelium is lacking ...
Beatrice Mihaela Radu, Antonio Marco Maria Osculati, Eda Suku, Adela Banciu, Grygoriy Tsenov, Flavia Merigo, Marzia Di Chio, Daniel Dumitru Banciu, Cristina Tognoli, Petr Kačer, Alejandro Giorgetti, Mihai Radu, Giuseppe Bertini, Paolo Francesco Fabene   +13 more
openalex   +6 more sources

Microscopic Binding of M5 Muscarinic Acetylcholine Receptor with Antagonists by Homology Modeling, Molecular Docking, and Molecular Dynamics Simulation [PDF]

The Journal of Physical Chemistry B, 2011
By performing homology modeling, molecular docking, and molecular dynamics (MD) simulations, we have developed three-dimensional (3D) structural models of the M5 muscarinic acetylcholine receptor (mAChR) and two complexes for M5 mAChR binding with antagonists SVT-40776 and solifenacin in the environment of lipid bilayer and solvent water.
Xiaoqin Huang, Guangrong Zheng, Chang‐Guo Zhan   +2 more
openalex   +4 more sources