Results 1 to 10 of about 7,565 (222)

Molecular Conversion of Muscarinic Acetylcholine Receptor M5 to Muscarinic Toxin 7 (MT7)-Binding Protein [PDF]

Toxins, 2011
Muscarinic toxin 7 (MT7) is a mamba venom peptide that binds selectively to the M1 muscarinic acetylcholine receptor. We have previously shown that the second (ECL2) and third (ECL3) extracellular loops of the M1 receptor are critically involved in ...
Katja Näreoja, Johnny Näsman, Sergio Rondinelli   +2 more
doaj   +2 more sources

Long-Term—But Not Short-Term—Plasticity at the Mossy Fiber–CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice [PDF]

Cells, 2023
Muscarinic acetylcholine receptors are well-known for their crucial involvement in hippocampus-dependent learning and memory, but the exact roles of the various receptor subtypes (M1–M5) are still not fully understood.
Fang Zheng, Jürgen Wess, Christian Alzheimer   +2 more
doaj   +2 more sources

Efficacy of a Muscarinic (M1) Positive Allosteric Modulator, SUVN‐I7016031 in Animal Models of Dementia [PDF]

Alzheimers Dement
Abstract Background SUVN‐I7016031 is a novel and selective positive allosteric modulator (PAM) of the M1 subtype of the muscarinic acetylcholine receptors (mAChRs). The proposed primary indication for SUVN‐I7016031 is in the treatment of dementia such as Alzheimer’s disease dementia (ADD) and Parkinson’s disease dementia (PDD). In the current research,
Abraham R, Medapati R, Petlu S, Subramanian R, Badange R, Bojja K, Shinde A, Molgara P, Nirogi R.   +8 more
europepmc   +2 more sources

A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity. [PDF]

Pharmaceutics, 2023
Anticholinergic burden tools have relevant pharmacological gaps that may explain their limited predictive ability for clinical outcomes. The aim of this study was to provide a universal pharmacological-based list of drugs with their documented affinity ...
Lavrador M, Cabral AC, Veríssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM.   +5 more
europepmc   +3 more sources

Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell-cell junctions. [PDF]

Reproduction, 2021
Han X, Zhang C, Ma X, Yan X, Xiong B, Shen W, Yin S, Zhang H, Sun Q, Zhao Y.   +9 more
europepmc   +3 more sources

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice

Neurobiology of Disease, 2006
The M5 muscarinic acetylcholine receptor (M5R) has been shown to play a crucial role in mediating acetylcholine-dependent dilation of cerebral blood vessels.
Runa Araya, Takanori Noguchi, Munehiro Yuhki, Naohito Kitamura, Makoto Higuchi, Takaomi C. Saido, Kenjiro Seki, Shigeyoshi Itohara, Masako Kawano, Kentaro Tanemura, Akihiko Takashima, Kazuyuki Yamada, Yasushi Kondoh, Iwao Kanno, Jürgen Wess, Masahisa Yamada   +15 more
doaj   +2 more sources

A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor [PDF]

, 2010
Muscarinic acetylcholine receptors (MRs), a family of five G protein-coupled receptors (GPCRs), play an essential role in the regulation of mammalian physiology.
Jacob Bendor
openalex   +2 more sources

Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3 [PDF]

, 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine.
Birdsall, Nigel J. M., Bradley, Sophie, Brown, David A., Buckley, Noel J., Challiss, R.A. John, Christopoulos, Arthur, Eglen, Richard M., Ehlert, Frederick, Felder, Christian C., Hammer, Rudolf, Kilbinger, Heinz J., Lambrecht, Günter, Langmead, Chris, Mitchelson, Fred, Mutschler, Ernst, Nathanson, Neil M., Schwarz, Roy D., Thal, David, Tobin, Andrew B., Valant, Celine, Wess, Jurgen   +20 more
core   +3 more sources

Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1 [PDF]

, 2023
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine.
Birdsall, Nigel J. M., Bradley, Sophie, Brown, David A., Buckley, Noel J., Challiss, R.A. John, Christopoulos, Arthur, Eglen, Richard M., Ehlert, Frederick, Felder, Christian C., Hammer, Rudolf, Kilbinger, Heinz J., Lambrecht, Günter, Langmead, Chris, Mitchelson, Fred, Mutschler, Ernst, Nathanson, Neil M., Schwarz, Roy D., Thal, David, Tobin, Andrew B., Valant, Celine, Wess, Jurgen   +20 more
core   +2 more sources

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source