Results 101 to 110 of about 5,023 (210)

Adrenergic receptors. Models for regulation of signal transduction processes. [PDF]

, 1990
Adrenergic receptors are prototypic models for the study of the relations between structure and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene.
Caron, MG, Hnatowich, M, Lefkowitz, RJ, Raymond, JR   +3 more
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Age-related changes in afferent pathways and urothelial function in the male mouse bladder [PDF]

, 2013
Key points •The prevalence of bladder conditions such as overactive bladder syndrome and urinary incontinence significantly increases with age, but how bladder function is altered by ageing is unclear.
Christopher Chapple, Chuang Y‐C, David Grundy, Donna M. Daly, Linda Nocchi, Marina Liaskos, Mohammed HA, Neil G. McKay   +7 more
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Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor [PDF]

, 2013
Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus.
Arthur Christopoulos, Aurelio L., Avlani V. A., Barbosa J., Bell R. P., Ben Capuano, Bunce R. A., Canals M., Cao X., Casara P., Celine Valant, Conn P. J., Decker M., Eaton P. E., Gould R. G., Holden M., Koguro K., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Langmead C. J., Lauer W. M., Leach K., Ma L., Maffioli S. I., Meanwell N. A., Medeiros R. R., Patrick M. Sexton, Peter J. Scammells, Podányi B., Reid P. R., Shailesh N. Mistry, Shirey J. K., Wess J., Wise W. M., Yang F. V., Zewge D., Zhang Y., Škugor M. M.   +43 more
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G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]

, 2009
Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
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Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Muscarinic acetylcholine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [45]) are GPCRs of the Class A, rhodopsin-like family where the endogenous agonist is acetylcholine.
Birdsall, Nigel J. M., Bradley, Sophie, Brown, David A., Buckley, Noel J., Challiss, R.A. John, Christopoulos, Arthur, Eglen, Richard M., Ehlert, Frederick, Felder, Christian C., Hammer, Rudolf, Kilbinger, Heinz J., Lambrecht, Günter, Langmead, Chris, Mitchelson, Fred, Mutschler, Ernst, Nathanson, Neil M., Schwarz, Roy D., Tobin, Andrew B., Valant, Celine, Wess, Jurgen   +19 more
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Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. [PDF]

, 2013
Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
Almasy, Laura, Bauer, Lance, Bierut, Laura, Bucholz, Kathleen, Chorlian, David B, Dick, Danielle, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Hesselbrock, Victor, Kang, Sun J, Kramer, John, Kuperman, Sam, Manz, Niklas, Nurnberger, John, Porjesz, Bernice, Rangaswamy, Madhavi, Rice, John, Schuckit, Marc, Tischfield, Jay, Wang, Jen-Chyong   +20 more
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Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]

, 2016
The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, DONNARUMMA, ERMINIA, FUSCO, FERDINANDO, MIRONE, VINCENZO, MITIDIERI, EMMA, Pagliara, Valentina, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA, Tramontano, Teresa   +10 more
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Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj  

Acetylcholine Increases the Free Intracellular Calcium Concentration in Podocytes in Intact Rat Glomeruli via Muscarinic M5 Receptors [PDF]

, 2001
Roland Nitschke, Anna Henger, Sigrid Ricken, VICTORIA MUCombining DiaeresisLLER, MICHAEL KOCombining DiaeresisTTGEN, Martin J. Bek, Hermann PavenstaCombining Diaeresisdt   +6 more
openalex   +1 more source

Human HT-29 colon carcinoma cells contain mucarinic M\(_3\) receptors coupled to phosphoinositide metabolism [PDF]

, 1989
Five different musearlnie receptor subtypes ean be distinguished by the differenees in their amino aeid sequence, the eoupled signal transduetion system, pharmaeologieal binding properties and aetivation of ionie fluxes.
Kopp, R., Lambrecht, G., Moser, U., Mutschler, E., Pfeiffer, A., Tacke, Reinhold   +5 more
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