Results 101 to 110 of about 20,015 (223)

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources

Enhanced arecoline derivatives as muscarinic acetylcholine receptor M1 ligands for potential application as PET radiotracers.

European journal of medicinal chemistry, 2020
Supported by their involvement in many neurodegenerative disorders, muscarinic acetylcholine receptors (mAChRs) are an interesting target for PET imaging. Nevertheless, no radiotracer is established in clinical routine. Within this work we aim to develop
M. Ozenil, Katharina Pacher, T. Balber, C. Vraka, A. Roller, W. Holzer, H. Spreitzer, M. Mitterhauser, W. Wadsak, M. Hacker, V. Pichler   +10 more
semanticscholar   +1 more source

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases

Orthopaedic Surgery, Volume 17, Issue 6, Page 1561-1576, June 2025.
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Ruihao Xia, Hongjun Peng, Xishan Zhu, Wangdui Suolang, Steve T. L. Pambayi, Xiao Yang, Yi Zeng, Bin Shen   +7 more
wiley   +1 more source

D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks

Pharmaceutical Science Advances
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs ...
Md. Elit Rahman, Md. Anisur Rahman, Salehin Sheikh, Md. Jannatul Islam Polash, Sozoni Khatun, Mst. Sonia Akter Bristi, Md. Showkoth Akbor, Mst. Farjanamul Haque, Mehedi Hasan Bappi, Tohidul Islam Tanim, Siddique Akber Ansari, Irfan Aamer Ansari, Elaine Cristina Pereira Lucetti, Carolina Bandeira Domiciano, Henrique D.M. Coutinho, Muhammad Torequl Islam   +15 more
doaj   +1 more source

G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]

, 2009
Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
core  

Autoantibodies against muscarinic receptors in breast cancer. Its role in tumor angiogenesis. [PDF]

, 2013
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
Azar, María Eugenia, Castro, Maria Ester, Cresta Morgado Carlos, Fiszman, Gabriel Leon, Lombardi, Maria Gabriela, Negroni, María Pía, Pelegrina, Laura Tatiana, Sales Maria Elena   +7 more
core   +1 more source

The M1 muscarinic acetylcholine receptor in the crypt stem cell compartment mediates intestinal mucosal growth

Experimental biology and medicine, 2020
Maintenance of the highly plastic intestinal epithelium relies upon stem cells localized to intestinal crypts. Recent evidence suggests muscarinic acetylcholine signaling impacts epithelial barrier function, proliferation, and apoptosis.
Chasen J Greig, Sarah J. Armenia, R. Cowles   +2 more
semanticscholar   +1 more source

Anticholinergic burden quantified using the Japanese risk scale as a predictor of frailty and sarcopenia among community‐dwelling older adults: A 9‐year Kashiwa cohort study

Geriatrics &Gerontology International, Volume 25, Issue 4, Page 520-527, April 2025.
Anticholinergic burden, quantified using the Japanese Anticholinergic Drug Risk Scale, may be a predictor of frailty and sarcopenia in community‐dwelling older adults. Effective evaluation and management of anticholinergic burden using the Japanese Anticholinergic Drug Risk Scale are crucial for promoting healthy aging and mitigating adverse health ...
Tomoki Tanaka, Masahiro Akishita, Taro Kojima, Bo‐Kyung Son, Katsuya Iijima   +4 more
wiley   +1 more source

Morphologic evaluation and Ca2+ mobilization by glicose and acetylcholine in human pancreatic cells [PDF]

, 2007
AIMS: The proposal of this study was to analyze morphology of the organelles and cytoskeleton in human pancreatic cells cultured and the mobilization of the cytosolic calcium ([Ca2+]c) in response to glucose and ACh by fluorimetry method.
Cardoso, Daniela Espinha, Chinen, Elisângela, Ferreira, Alice Teixeira, França, Jerônimo Pereira de, França, Lucimar Pereira de, Moraes, Andrea Aparecida Fátima Souza   +5 more
core   +3 more sources

Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]

, 2010
To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
core   +2 more sources