Results 101 to 110 of about 5,198 (201)

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor [PDF]

, 2013
Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus.
Arthur Christopoulos, Aurelio L., Avlani V. A., Barbosa J., Bell R. P., Ben Capuano, Bunce R. A., Canals M., Cao X., Casara P., Celine Valant, Conn P. J., Decker M., Eaton P. E., Gould R. G., Holden M., Koguro K., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Langmead C. J., Lauer W. M., Leach K., Ma L., Maffioli S. I., Meanwell N. A., Medeiros R. R., Patrick M. Sexton, Peter J. Scammells, Podányi B., Reid P. R., Shailesh N. Mistry, Shirey J. K., Wess J., Wise W. M., Yang F. V., Zewge D., Zhang Y., Škugor M. M.   +43 more
core   +2 more sources

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. [PDF]

, 2013
Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
Almasy, Laura, Bauer, Lance, Bierut, Laura, Bucholz, Kathleen, Chorlian, David B, Dick, Danielle, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Hesselbrock, Victor, Kang, Sun J, Kramer, John, Kuperman, Sam, Manz, Niklas, Nurnberger, John, Porjesz, Bernice, Rangaswamy, Madhavi, Rice, John, Schuckit, Marc, Tischfield, Jay, Wang, Jen-Chyong   +20 more
core   +2 more sources

Human HT-29 colon carcinoma cells contain mucarinic M\(_3\) receptors coupled to phosphoinositide metabolism [PDF]

, 1989
Five different musearlnie receptor subtypes ean be distinguished by the differenees in their amino aeid sequence, the eoupled signal transduetion system, pharmaeologieal binding properties and aetivation of ionie fluxes.
Kopp, R., Lambrecht, G., Moser, U., Mutschler, E., Pfeiffer, A., Tacke, Reinhold   +5 more
core  

P2‐207: Discovery of a highly M5‐preferring muscarinic acetylcholine receptor allosteric potentiator [PDF]

Alzheimer's & Dementia, 2009
Thomas M. Bridges, Joy E. Marlo, Colleen M. Niswender, Patrick R. Gentry, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley   +6 more
openaire   +1 more source

中枢神経系疾患治療薬の創製に向けた評価系の構築と行動薬理学的研究 [PDF]

, 2015
関西大
Nakako Tomokazu, 仲子 友和
core   +1 more source

Computational Evaluation of Substituted 2-Aminopyrimidine Schiff Bases as Potential Antidepressant Targeting the Muscarinic Acetylcholine M5 Receptor

Journal of Neonatal Surgery
The effectiveness of existing treatments for depression, a complicated mental health condition that affects people all over the world, is limited. The ability of the muscarinic acetylcholine receptor subtype M5 (M5 mAChR) to modulate dopaminergic and cholinergic pathways has made it a unique target in the search for antidepressant drugs. This work used
Smita Sunil Sawalwade, Bhavna Utkarsh Jain, Sonali Sanjay Nikam, Snehal Prakash Patil   +3 more
openaire   +1 more source

Discovery of M5 Muscarinic Acetylcholine Receptor Antagonists: 1‐Methyl‐4‐Phenylpiperidine Analogs

The FASEB Journal, 2015
Na‐Ra Lee, Xuan Zhang, Mahesh Darna, Guangrong Zheng, Linda Dwoskin   +4 more
openaire   +1 more source

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust <i>In Vivo</i> Efficacy. [PDF]

ACS Chem Neurosci
Gregro AR, Park C, Long MF, Baker LA, Bollinger KA, Ringuette AE, Peng L, Luscombe VB, Billard NB, Rodriguez AL, Niswender CM, Peng W, Dickerson JW, Rook JM, O'Neill J, Chang S, Boonen HCM, Jensen T, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +24 more
europepmc   +1 more source

Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference? [PDF]

J Psychopharmacol
Pratt JA, Morris BJ.
europepmc   +1 more source

Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium [PDF]

, 2018
Chess-Williams, Russ, Michel, Martin C., Sellers, Donna   +2 more
core   +1 more source