Morphologic evaluation and Ca2+ mobilization by glicose and acetylcholine in human pancreatic cells [PDF]
, 2007 AIMS: The proposal of this study was to analyze morphology of the organelles and cytoskeleton in human pancreatic cells cultured and the mobilization of the cytosolic calcium ([Ca2+]c) in response to glucose and ACh by fluorimetry method.
Cardoso, Daniela Espinha +5 more
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The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]
, 2018 Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth +6 more
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Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor [PDF]
, 2016 Benzoquinazolinone 1 is a positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor (mAChR), which is significantly more potent than the prototypical PAM, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline- 3-carboxylic acid (BQCA). In
Capuano, Ben +8 more
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G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]
, 2009 Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
core
Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor [PDF]
, 2013 Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus.
Arthur Christopoulos +43 more
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Age-related changes in afferent pathways and urothelial function in the male mouse bladder [PDF]
, 2013 Key points •The prevalence of bladder conditions such as overactive bladder syndrome and urinary incontinence significantly increases with age, but how bladder function is altered by ageing is unclear.
Christopher Chapple +7 more
core +1 more source
Adrenergic receptors. Models for regulation of signal transduction processes. [PDF]
, 1990 Adrenergic receptors are prototypic models for the study of the relations between structure and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene.
Caron, MG +3 more
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Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli [PDF]
, 2000 The M2 muscarinic acetylcholine receptor mutant (M2 mutant), with a lack of glycosylation sites, a deletion in the central part of the third inner loop, and the addition of a six histidine tag at the C-terminus, was fused to maltose binding protein (MBP)
Furukawa, H., Haga, T.
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Human HT-29 colon carcinoma cells contain mucarinic M\(_3\) receptors coupled to phosphoinositide metabolism [PDF]
, 1989 Five different musearlnie receptor subtypes ean be distinguished by the differenees in their amino aeid sequence, the eoupled signal transduetion system, pharmaeologieal binding properties and aetivation of ionie fluxes.
Kopp, R. +5 more
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Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization [PDF]
, 2013 Keywords:adenosine;allosterism;receptor;GPCR;dimerization;biased signalling The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It is released under a variety of physiological and pathophysiological conditions to
Albrecht-Kupper +114 more
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