A physical model of nicotinic ACh receptor kinetics [PDF]
arXiv, 2008 We present a new approach to nicotinic receptor kinetics and a new model explaining random variabilities in the duration of open events. The model gives new interpretation on brief and long receptor openings and predicts (for two identical binding sites) the presence of three components in the open time distribution: two brief and a long.
arxiv
Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life [PDF]
, 2012 Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism.
Clarice Gravena +3 more
core +1 more source
Angewandte Chemie International Edition, Volume 63, Issue 52, December 20, 2024.l‐(+)‐Muscarine is one of the most toxic mushroom metabolites. We identified its congener 4’‐phosphomuscarine in the fool's funnel and in various fiber cap mushrooms, and chemically and pharmacologically characterized this new natural product. As hydrolysis of its ester releases muscarine, our results help estimate the true toxin content of these ...
Sebastian Dörner +7 more
wiley +1 more source
The Channel Capacity of Channelrhodopsin and Other Intensity-Driven Signal Transduction Receptors [PDF]
arXiv, 2018 Biological systems transduce signals from their surroundings through a myriad of pathways. In this paper, we describe signal transduction as a communication system: the signal transduction receptor acts as the receiver in this system, and can be modeled as a finite-state Markov chain with transition rates governed by the input signal.
arxiv
Advancing Neural Networks: Innovations and Impacts on Energy Consumption
Advanced Electronic Materials, Volume 10, Issue 12, December 2024.A comparative study of ANN and SNN including biological neural networks is presented. An inefficiency of 5–8 orders of magnitude is indicated for modern ANN approaches, with the worst Transformer ANN over CPU. The most efficient implementation of the SNNs is biological neurons with only 100 fJ per synaptic weight update, next is inorganic Mosaic ...
Alina Fedorova +9 more
wiley +1 more source
Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes [PDF]
arXiv, 2019 At the neuromuscular junction (NMJ), the nicotinic acetylcholine receptor (nAChR) self-associates to give rise to rapid muscle movement. While lipid domains have maintained nAChR aggregates in-vitro, their specific roles in nAChR clustering are currently unknown. In the present study, we carried out coarse-grained molecular dynamics simulations (CG-MD)
arxiv
G fehérjék szerepe a húgyhólyag simaizom-működésének szabályozásában. = G protein-mediated regulation of urinary smooth muscle contractility. [PDF]
, 2009 Eredményeink szerint élettani körülmények között a Gq/11 jelátviteli út (vélhetőleg az M3-receptorok által aktiválva) döntő szerepet játszik az acetilkolin simaizom-kontrakciót okozó hatásának közvetítésében és ezáltal a húgyhólyag működésének ...
Benyó, Zoltán
core
The actions of Pasteurella multocida toxin on neuronal cells [PDF]
, 2014 Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Duricki, DA +4 more
core +1 more source
Photo‐BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor
Angewandte Chemie International Edition, Volume 63, Issue 47, November 18, 2024.Photoswitchable allosteric modulators for the Class A of a G protein‐coupled receptor, themuscarinic acetylcholine receptor subtype 1 (M1R) were developed based on the allosteric modulator benzyl quinolone carboxylic acid (BQCA) exploiting its flat structure–activity relationships.
Hubert Gerwe +8 more
wiley +1 more source
On the role of G protein-coupled receptors oligomerization [PDF]
, 2013 The existence of a supramolecular organization of the G protein-coupled receptor (GPCR) is now being widely accepted by the scientific community.
Ahern, Siobhán +3 more
core +2 more sources