Results 11 to 20 of about 19,182 (246)

Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell–cell junctions [PDF]

Reproduction, 2020
Muscarinic acetylcholine receptor (mAChR) antagonists have been reported to decrease male fertility; however, the roles of mAChRs in spermatogenesis and the underlying mechanisms are not understood yet.
Xiao Han, Cong Zhang, Xiangping Ma, Xiaowei Yan, Bohui Xiong, W. Shen, S. Yin, Hongfu Zhang, Qingyuan Sun, Yong Zhao   +9 more
semanticscholar   +3 more sources

Crystal structure of the M5 muscarinic acetylcholine receptor [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance The 5 subtypes of the muscarinic acetylcholine receptors (mAChRs) are expressed throughout the central and peripheral nervous system where they play a vital role in physiology and pathologies. Recently, the M5 mAChR subtype has emerged as an
Ziva Vuckovic, P. Gentry, Alice E. Berizzi, K. Hirata, Swapna Varghese, Geoff V. Thompson, E. T. van der Westhuizen, Wessel A. C. Burger, Raphaël Rahmani, C. Valant, C. Langmead, C. Lindsley, J. Baell, A. Tobin, P. Sexton, A. Christopoulos, D. Thal   +16 more
semanticscholar   +7 more sources

Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum

The Journal of Pharmacology and Experimental Therapeutics, 2023
The type-5 muscarinic acetylcholine receptor (mAChR, M5) is almost exclusively expressed in dopamine (DA) neurons of the ventral tegmental area and substantia nigra pars compacta; therefore, they are ideally located to modulate DA signaling and ...
Vivien Zell, Greetje Teuns, A. S. Needham, Sruti Mukherjee, Nathaniel Roscoe, Michelle Le, Lawrence Fourgeaud, Grace Woodruff, Anindya Bhattacharya, Mathieu Marella, Pascal Bonaventure, Wayne C. Drevets, B. Balana   +12 more
semanticscholar   +3 more sources

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases. [PDF]

Orthop Surg
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Xia R, Peng H, Zhu X, Suolang W, Pambayi STL, Yang X, Zeng Y, Shen B.   +7 more
europepmc   +2 more sources

Efficacy of a Muscarinic (M1) Positive Allosteric Modulator, SUVN‐I7016031 in Animal Models of Dementia [PDF]

Alzheimers Dement
Abstract Background SUVN‐I7016031 is a novel and selective positive allosteric modulator (PAM) of the M1 subtype of the muscarinic acetylcholine receptors (mAChRs). The proposed primary indication for SUVN‐I7016031 is in the treatment of dementia such as Alzheimer’s disease dementia (ADD) and Parkinson’s disease dementia (PDD). In the current research,
Abraham R, Medapati R, Petlu S, Subramanian R, Badange R, Bojja K, Shinde A, Molgara P, Nirogi R.   +8 more
europepmc   +2 more sources

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice

Neurobiology of Disease, 2006
The M5 muscarinic acetylcholine receptor (M5R) has been shown to play a crucial role in mediating acetylcholine-dependent dilation of cerebral blood vessels.
Runa Araya, Takanori Noguchi, Munehiro Yuhki, Naohito Kitamura, Makoto Higuchi, Takaomi C. Saido, Kenjiro Seki, Shigeyoshi Itohara, Masako Kawano, Kentaro Tanemura, Akihiko Takashima, Kazuyuki Yamada, Yasushi Kondoh, Iwao Kanno, Jürgen Wess, Masahisa Yamada   +15 more
doaj   +4 more sources

Muscarinic acetylcholine receptor M5 is involved in spermatogenesis through the modification of cell-cell junctions. [PDF]

Reproduction, 2021
Muscarinic acetylcholine receptor (mAChR) antagonists have been reported to decrease male fertility; however, the roles of mAChRs in spermatogenesis and the underlying mechanisms are not understood yet. During spermatogenesis, extensive remodeling between Sertoli cells and/or germ cells interfaces takes place to accommodate the transport of developing ...
Han X, Zhang C, Ma X, Yan X, Xiong B, Shen W, Yin S, Zhang H, Sun Q, Zhao Y.   +9 more
europepmc   +4 more sources

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +2 more sources

Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation. [PDF]

The Journal of Physical Chemistry B, 2012
By performing homology modeling, molecular docking, and molecular dynamics (MD) simulations, we have developed three-dimensional (3D) structural models of the M5 muscarinic acetylcholine receptor (mAChR) and two complexes for M5 mAChR binding with ...
Xiaoqin Huang, Guangrong Zheng, C. Zhan
semanticscholar   +4 more sources

Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators [PDF]

Molecular Pharmacology, 2016
Recently, the first subtype-selective allosteric modulators of the M5 muscarinic acetylcholine receptor (mAChR) have been described, but their molecular mechanisms of action remain unknown. Using radioligand-binding and functional assays of inositol phosphate (IP) accumulation and Ca(2+) mobilization in a recombinant cell line stably expressing the ...
Alice E. Berizzi, P. Gentry, P. Rueda, Sandra Den Hoedt, P. Sexton, C. Langmead, A. Christopoulos   +6 more
semanticscholar   +3 more sources