Results 31 to 40 of about 19,182 (246)

Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models. [PDF]

, 2016
Pulmonary hypertension (PH) is a complex disease comprising a pathologic remodeling and thickening of the pulmonary vessels causing an after load on the right heart ventricle that can result in ventricular failure. Triggered by oxidative stress, episodes
Ahmed, Mohamed, Al-Abed, Yousef, Coleman, Thomas, Lakshminrusimha, Satyanarayana, Patel, Hardik, VanPatten, Sonya   +5 more
core   +2 more sources

Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor [PDF]

, 2013
Acetylcholine is an important neurotransmitter whose effects are mediated by two classes of receptors. The nicotinic acetylcholine receptors are ion channels, whereas the muscarinic receptors belong to the large family of G protein coupled seven ...
Acevedo, Antje Banning, Boman, Bonner, Caulfield, Caumont, Cheng, Claing, Coso, Crespo, Dascher, Delaney, Elorza, Ferguson, Fisher, Franco, Frucht, Grando, Grando, Hawes, Hawes, He, Hein, Hulme, Jin, Jones, Jones, Lee, Lee, Leiros, Lenhard, McCole, Michal, Miyakawa, Nguyen, Pals-Rylaarsdam, Pals-Rylaarsdam, Pitcher, Prenzel, Reiner, Ritva Tikkanen, Roseberry, Rosenblum, Shah, Simone Bocksberger, Sina Kühne, Taylor, Tohgo, Tsuga, van Biesen, van Koppen, Vogler, Vogler, Wang, Wickman, Williams, Wu, Wymke Ockenga, Zhang   +58 more
core   +3 more sources

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

, 2006
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
58998, 58999, IINO, Satoshi, NOJYO, Yoshiaki   +3 more
core   +1 more source

Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3 [PDF]

, 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine.
Birdsall, Nigel J. M., Bradley, Sophie, Brown, David A., Buckley, Noel J., Challiss, R.A. John, Christopoulos, Arthur, Eglen, Richard M., Ehlert, Frederick, Felder, Christian C., Hammer, Rudolf, Kilbinger, Heinz J., Lambrecht, Günter, Langmead, Chris, Mitchelson, Fred, Mutschler, Ernst, Nathanson, Neil M., Schwarz, Roy D., Thal, David, Tobin, Andrew B., Valant, Celine, Wess, Jurgen   +20 more
core   +3 more sources

Virtual Affinity Fingerprints for Target Fishing: A New Application of Drug Profile Matching [PDF]

, 2013
We recently introduced Drug Profile Matching (DPM), a novel virtual affinity fingerprinting bioactivity prediction method. DPM is based on the docking profiles of ca.
Czobor, P., Hári, P., Jelinek, B., Málnási Csizmadia, András, Peragovics, Á., Simon, Z., Tombor, L.   +6 more
core   +1 more source

Spontaneous Lipid Binding to the Nicotinic Acetylcholine Receptor in a Native Membrane [PDF]

, 2021
The nicotinic acetylcholine receptor (nAChR) and other pentameric ligand-gated ion channels (pLGICs) are native to neuronal membranes with an unusual lipid composition. While it is well-established that these receptors can be significantly modulated by lipids, the underlying mechanisms have been primarily studied in model membranes with only a few ...
arxiv   +1 more source

Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat () [PDF]

, 2016
The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M(1) and M(4).
Abelson, Klas, Jørgensen, Kristine B., Kanui, Titus, Krogh-Jensen, Karen, Pickering, Darryl S   +4 more
core   +4 more sources

Characterization of a new muscarinic toxin from the venom of the Brazilian coral snake Micrurus lemniscatus in rat hippocampus [PDF]

, 2011
AimsWe have isolated a new muscarinic protein (MT-Mlα) from the venom of the Brazilian coral snake Micrurus lemniscatus.Main methodsThis small protein, which had a molecular mass of 7,048Da, shared high sequence homology with three-finger proteins that ...
Abdalla, Fernando Maurício Francis, Batista, Isabel de Fátima Correia, da Silva, Daniel Coelho, de Medeiros, Wyara Aparecida Araújo, Lebrun, Ivo, Pimenta, Daniel Carvalho, Sandoval, Maria Regina Lopes   +6 more
core   +1 more source

Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1 [PDF]

, 2023
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine.
Birdsall, Nigel J. M., Bradley, Sophie, Brown, David A., Buckley, Noel J., Challiss, R.A. John, Christopoulos, Arthur, Eglen, Richard M., Ehlert, Frederick, Felder, Christian C., Hammer, Rudolf, Kilbinger, Heinz J., Lambrecht, Günter, Langmead, Chris, Mitchelson, Fred, Mutschler, Ernst, Nathanson, Neil M., Schwarz, Roy D., Thal, David, Tobin, Andrew B., Valant, Celine, Wess, Jurgen   +20 more
core   +2 more sources

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Aslanoglou, Despoina, Marsango, Sara, Milligan, Graeme   +3 more
core   +1 more source