Results 81 to 90 of about 5,170 (209)

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases

Orthopaedic Surgery, Volume 17, Issue 6, Page 1561-1576, June 2025.
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Ruihao Xia, Hongjun Peng, Xishan Zhu, Wangdui Suolang, Steve T. L. Pambayi, Xiao Yang, Yi Zeng, Bin Shen   +7 more
wiley   +1 more source

Anticholinergic burden quantified using the Japanese risk scale as a predictor of frailty and sarcopenia among community‐dwelling older adults: A 9‐year Kashiwa cohort study

Geriatrics &Gerontology International, Volume 25, Issue 4, Page 520-527, April 2025.
Anticholinergic burden, quantified using the Japanese Anticholinergic Drug Risk Scale, may be a predictor of frailty and sarcopenia in community‐dwelling older adults. Effective evaluation and management of anticholinergic burden using the Japanese Anticholinergic Drug Risk Scale are crucial for promoting healthy aging and mitigating adverse health ...
Tomoki Tanaka, Masahiro Akishita, Taro Kojima, Bo‐Kyung Son, Katsuya Iijima   +4 more
wiley   +1 more source

Regulation of Src Family Tyrosine Kinases in the Rat Striatum by Muscarinic Acetylcholine Receptors [PDF]

, 2017
Acetylcholine is an important neurotransmitter in the mammalian brain. This transmitter binds to muscarinic acetylcholine receptors (mAChR) to regulate activity of a variety of intracellular signaling molecules.
Faris, Hunter
core  

Alcohol addiction: a molecular biology perspective. [PDF]

, 2015
Alcohol misuse represents worldwide an important risk factor for death and disability. Excessive alcohol consumption is widely diffused in different ethnicities and alcohol use is part of the lifestyle of both young and old people.
Ferraguti, Giampiero, Lucarelli, Marco, Pascale, Esterina   +2 more
core   +1 more source

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources

Hippocampal Inhibitory Interneuron‐Specific DREADDs Treatment Alters mTORC1‐4E‐BP Signaling and Impairs Memory Formation

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
We used advanced tools called DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to control the activity of inhibitory neurons versus excitatory neurons in the hippocampus, a region of the brain critical for learning and memory. By activating or inactivating these neurons after training, we found that disrupting their normal activity ...
Ziying Huang, Niaz Mahmood, Jean‐Claude Lacaille, Shane Wiebe, Nahum Sonenberg   +4 more
wiley   +1 more source

D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks

Pharmaceutical Science Advances
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs ...
Md. Elit Rahman, Md. Anisur Rahman, Salehin Sheikh, Md. Jannatul Islam Polash, Sozoni Khatun, Mst. Sonia Akter Bristi, Md. Showkoth Akbor, Mst. Farjanamul Haque, Mehedi Hasan Bappi, Tohidul Islam Tanim, Siddique Akber Ansari, Irfan Aamer Ansari, Elaine Cristina Pereira Lucetti, Carolina Bandeira Domiciano, Henrique D.M. Coutinho, Muhammad Torequl Islam   +15 more
doaj   +1 more source

Autoantibodies against muscarinic receptors in breast cancer. Its role in tumor angiogenesis. [PDF]

, 2013
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
Azar, María Eugenia, Castro, Maria Ester, Cresta Morgado Carlos, Fiszman, Gabriel Leon, Lombardi, Maria Gabriela, Negroni, María Pía, Pelegrina, Laura Tatiana, Sales Maria Elena   +7 more
core   +1 more source

Muscarinic receptor blockade with oxybutynin reduces spontaneous and induced uterine muscle contractions

Pregnancy, Volume 1, Issue 1, January 2025.
Abstract Objective The uterus and the bladder have striking physiologic and anatomic similarities. Anticholinergic medications are commonly used to treat “overactive bladder” by targeting M2 and M3 muscarinic receptors. The uterus also contains M2 and M3 muscarinic receptors; however, current management of preterm labor does not target these receptors.
Anthony G. Visco, Zachary R. Visco, Chad A. Grotegut, Cristina Linde, Timothy Westfall, Friederike L. Jayes   +5 more
wiley   +1 more source

Memory consolidation — Mechanisms and opportunities for enhancement [PDF]

, 2013
Memory consolidation is the process by which relevant information is selected and transferred from a short-term, fragile state, into a stable, longer term domain from which it can be recalled.
Coulthard, E J, Shaikh, Netasha N
core   +1 more source