Results 81 to 90 of about 5,023 (210)

Repositioning VU‐0365114 as a novel microtubule‐destabilizing agent for treating cancer and overcoming drug resistance

Molecular Oncology
Microtubule‐targeting agents represent one of the most successful classes of anticancer agents. However, the development of drug resistance and the appearance of adverse effects hamper their clinical implementation.
Yao‐Yu Hsieh, Jia‐Ling Du, Pei‐Ming Yang   +2 more
doaj   +1 more source

Hippocampal Inhibitory Interneuron‐Specific DREADDs Treatment Alters mTORC1‐4E‐BP Signaling and Impairs Memory Formation

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
We used advanced tools called DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to control the activity of inhibitory neurons versus excitatory neurons in the hippocampus, a region of the brain critical for learning and memory. By activating or inactivating these neurons after training, we found that disrupting their normal activity ...
Ziying Huang, Niaz Mahmood, Jean‐Claude Lacaille, Shane Wiebe, Nahum Sonenberg   +4 more
wiley   +1 more source

Calcium Mobilization by Activation of M3/M5 Muscarinic Receptors in the Human Retinoblastoma

Journal of Pharmacological Sciences, 2007
Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. In this study, we investigated the role of mAChR activation in relation to its subtypes in human retinoblastoma cell ...
Dae-Ran Kim, Sang Hoon Rah, Joon Hyung Sohn, Byung-Il Yeh, Chang Mann Ko, Jeong Sook Park, Min-Jeong Kim, Joong Woo Lee, In Deok Kong   +8 more
doaj  

Expression and function of G-protein-coupled receptorsin the male reproductive tract [PDF]

, 2009
This review focuses on the expression and function of muscarinic acetylcholine receptors (mAChRs), α1-adrenoceptors and relaxin receptors in the male reproductive tract.
ABOUD R, ALONSO-LLAMAZARES A, ANAND-IVELL RJ, ANDERSON MB, BAN Y, BATHGATE RA, BATHGATE RA, BERNARD V, BERNARD V, BHATHAL PS, BIRDSALL NJ, BISHOP MJ, BLANCO M, BOGIC L, BORGES MOR, BRADDON SA, BRODDE OE, BURAZIN TC, BURT RP, BURT RP, CAMPOS M, Catarina S. Porto, CAULFIELD MP, CHALOTHORN D, CHAN HC, CHANG DJ, CHATURAPANICH G, CHEAH SH, CHEN S, CHEN S, COGÉ F ET AL, DA SILVA MC, DALY CJ, DANIELS DV, DAVENPORT CW, DEBRUYNE FM, DENG XF, DIVIANI D, DOCHERTY JR, DOCHERTY JR, DOGGRELL SA, DU JY, EGLEN RM, EGLEN RM, EHRÉN I, EISENHOFER G, ERRASTI AE, ESBENSHADE TA, ESSIG M, FENG S, FEVOLD HL, FILONZI M, FORD APDW, FORD APDW, FORRAY C, FUKASAWA R, GAO B, GAO B, GOBEIL F JR, GONZÁLEZ-ESPINOSA C, GRAHAM RM, GRIMM U, GUNNERSEN JM, GUNNERSEN JM, HAAG C, HAGUE C, HAGUE C, HALLS ML, HALLS ML, HALLS ML, HAMAMURA M, HANFT G, HANSELL DJ, HAUSER F, HAWRYLYSHYN KA, HEIN P, HIB J, HIB J, HIEBLE JP, HIEBLE JP, HIRASAWA A, HIRASAWA A, HIRASAWA A, HISAW FL, HOMMA Y, HORIE K, HROMETZ SL, HSU SY, HSU SY, HU K, HULEIHEL M, HULME EC, HWA J, HWA J, HWA J, II M, IRAM S, IVELL R, IVELL R, JACKSON VM, JEYABALAN A, JEYABALAN A, JIANG X, JOCKENHOVEL F, JUDSON DG, JURKIEWICZ NH, KAMAT AA, KARKANIAS GB, KERN A, KIM JK, KINGHORN EM, KOHSAKA T, KONDO S, KRAJNC-FRANKEN MA, KUBO T, KUDO M, LACEY JP, LANGER S, LANZAFAME AA, LAU WA, LAZ TM, LEEB-LUNDBERG LM, LEFKOWITZ RJ, LEFKOWITZ RJ, LEFKOWITZ RJ, LENHART JA, LEPOR H, LEUNG AYH, LIU C, LOCKWOOD DH, LONGHURST PA, LOPEZ-GIMENEZ JF, LUCAS TFG, LUCAS TFG, LUTHIN GR, MACDONALD A, MACKENZIE JF, MACKINNON AC, MALLARD NJ, MANNI L, MANNI L, Maria Christina W. Avellar, Maria Fatima M. Lázari, MARKUS RP, MARÓSTICA E, MARÓSTICA E, MCCUNE DF, MCCUNE SK, MENDES FR, MICHELOTTI GA, MICHELOTTI GA, MIRANDA HF, MIRANDA HF, MIRANDA HF, MOOKERJEE I, MORIYAMA N, MORROW AL, MURAMATSU I, MURRAY KT, NADELHAFT I, NAKAOKA H, NASU K, NASU K, NEWINGER J, NISHIS, NOTHACKER HP, OBARA K, PAPATSORIS AG, PATRÃO MT, PEDRETTI A, PEREZ DM, PETITTI N, PIASCIK MT, PIASCIK MT, PIASCIK MT, PONTARI MA, PORTER JE, PRENZEL N, PRICE DT, PRICE DT, PRICE RR, PUPO AS, PUPO AS, QUEIRÓZ DB, QUEIRÓZ DBC, QUESADA A, RAMARAO CS, RAMSAY D, RATNASOORIYA WD, RATNASOORIYA WD, RAYFORD W, RICKER DD, ROEHRBORN CG, ROKOSH DG, ROKOSH DG, RUDNER XL, RUFFOLO RR JR, RUGGIERI MR, SALAMANCA AE, SALLÉS J, SAMUEL CS, SAMUEL CS, SAMUEL CS, SANBE A, SANBORN BM, SAROSI P, SATO T, SAUSSY DL JR, SAWUTZ DG, SCARPARO AC, SCHWINN DA, SCHWINN DA, SCOFIELD MA, SCOTT DJ, SCOTT DJ, SHANNON HE, SHAPIRO E, SHEN H, SHERWOOD OD, SHIMA S, SHINOURA H, SILVA MA, SIU ER, SKINNER MK, SOKOL RZ, STEINETZ BG, SUDO S, SUGAWARA T, SUZUKI F, TAYEBATI SK, TENG CM, TENSEN CP, TESTA R, THEBAULT S, THEROUX TL, TOEWS ML, UBERTI MA, UBERTI MA, VAN DIJK MM, VAN KOPPEN CJ, VARMA DR, VENTURA S, VICENTIC A, VIVAS NM, VÁZQUEZ-PRADO J, WALDEN PD, WALKER WH, WANG JM, WANG X ET AL, WAUGH DJ, WESS J, WIER WG, XIAO L, XU Z, YAN HH, YANG M, YANG-FENG TL, YANG-FENG TL, YASUOKA A, YAZAWA H, YAZAWA H, YKI-JARVINEN H, YOSHINAGA T, ZHAO L, ZHONG H, ZHONG H, ZIMMERMANN S, ZUSCIK MJ   +267 more
core   +3 more sources

Muscarinic receptor blockade with oxybutynin reduces spontaneous and induced uterine muscle contractions

Pregnancy, Volume 1, Issue 1, January 2025.
Abstract Objective The uterus and the bladder have striking physiologic and anatomic similarities. Anticholinergic medications are commonly used to treat “overactive bladder” by targeting M2 and M3 muscarinic receptors. The uterus also contains M2 and M3 muscarinic receptors; however, current management of preterm labor does not target these receptors.
Anthony G. Visco, Zachary R. Visco, Chad A. Grotegut, Cristina Linde, Timothy Westfall, Friederike L. Jayes   +5 more
wiley   +1 more source

Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. [PDF]

, 2006
The CHRM2 gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing.
Boomsma D.I., Cherny S.S., D. I. Boomsma, D. Posthuma, E. J. C. de Geus, Hulme E.C., J. C. Polderman, Levey A.I., Linder C.C., M. F. Gosso, M. van Belzen, Meulenbelt I., Miller S.A., Montagutelli X., P. Heutink, Quirion R., Wechsler D., Wechsler D., Wei J., Wess J., Zhang W.   +20 more
core   +3 more sources

Anticholinergic drugs and dementia risk: Using stem cell–based studies to complement pharmacoepidemiology

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.
Abstract BACKGROUND Anticholinergic (AC) use remains common in older adults despite evidence of safety risks, including increased risk in dementia. Pharmacoepidemiology studies from various populations report associations between specific anticholinergic classes – antidepressants and bladder antimuscarinics – and increased dementia incidence.
Tiara A. Schwarze‐Taufiq, Inez K. A. Pranoto, Katherine Hui, Chizuru Kinoshita, Onchee Yu, Paul K. Crane, Shelly L. Gray, Jessica E. Young   +7 more
wiley   +1 more source

Multiple Muscarinic Acetylcholine Receptor Subtypes Modulate Striatal Dopamine Release, as Studied with M₁–M₅Muscarinic Receptor Knock-Out Mice [PDF]

The Journal of Neuroscience, 2002
A proper balance between striatal muscarinic cholinergic and dopaminergic neurotransmission is required for coordinated locomotor control. Activation of striatal muscarinic acetylcholine receptors (mAChRs) is known to modulate striatal dopamine release.
Jürgen Wess, Weilie Zhang, Anthony S. Basile, Masahisa Yamada, Jesus Gomeza   +4 more
openaire   +3 more sources

Acetylcholine induces fibrogenic effects via M2/M3 ACh receptors in NASH and in primary human hepatic stellate cells [PDF]

, 2016
BACKGROUND: The parasympathetic nervous system (PNS), via neurotransmitter Acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear.
Cordero, P, McKee, C, Morgan, ML, Mouraliderane, A, Nguyen, V, Oben, JA, Sigala, B, Soeda, J, Vinciguerra, M   +8 more
core  

Autoantibodies against muscarinic receptors in breast cancer. Its role in tumor angiogenesis. [PDF]

, 2013
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
Azar, María Eugenia, Castro, Maria Ester, Cresta Morgado Carlos, Fiszman, Gabriel Leon, Lombardi, Maria Gabriela, Negroni, María Pía, Pelegrina, Laura Tatiana, Sales Maria Elena   +7 more
core   +1 more source