Results 201 to 210 of about 51,268 (235)
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Muscarinic Receptor Antagonists
2016Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
Maria Gabriella, Matera, Mario, Cazzola
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Selective Muscarinic Receptor Agonists and Antagonists
Pharmacology & Toxicology, 1996Abstract:Muscarinic receptors are composed of a family of four subtypes each of which can be distinguished pharmacologically and structurally. The physiological role of each subtype in the central and peripheral nervous systems remains to be clarified, due, in part, to a lack of agonists and antagonists with adequate subtype selectivity.
R M, Eglen, N, Watson
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Muscarinic receptor antagonists for overactive bladder
BJU International, 2007From time to time we publish a full review of drugs that are available for the treatment of common conditions. In this issue, the review is written by two of the leading authorities in the world, Paul Abrams and Karl‐Erik Andersson, on the topic of overactive bladder and antimuscarinic agents.
Paul, Abrams, Karl-Erik, Andersson
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Quinuclidin-2-ene - based muscarinic antagonists
Life Sciences, 1995A series of achiral 3-heteroaryl substituted quinuclidin-2-ene derivatives and related compounds have been synthesized by facile methods. The compounds were evaluated for muscarinic and antimuscarinic properties in receptor binding studies using (-)-[3H]-QNB as the radioligand and in a functional assay using isolated guinea pig urinary bladder.
U, Hacksell +5 more
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MUSCARINIC RECEPTOR ANTAGONISTS
1991A muscarinic receptor antagonist of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is N or (a) where R is H, halo or C1-C4 alkyl; R is H or C1-C4 alkyl; R is H or C1-C4 alkyl; Y is a direct link, O or S; m is an integer of from 1 to 4; n is 2 or 3; and R is 1- or 2-naphthyl or a group of formula (b), (c) or Het where R and R are ...
PFIZER LTD, PFIZER
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Muscarinic receptor agonists and antagonists
Expert Opinion on Therapeutic Patents, 1999Although four different subtypes of the muscarinic acetylcholine (ACh) receptor with functional correlates are known to exist (function for M5 is still unclear), all muscarinic agonists and antagon...
Darius P Zlotos +2 more
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Long-acting muscarinic antagonists
Expert Review of Clinical Pharmacology, 2015Chronic obstructive pulmonary disease (COPD) is a major cause of death and disability worldwide. Inhaled bronchodilators are the mainstay of COPD pharmacological treatment. Long-acting muscarinic antagonists (LAMAs) are a major class of inhaled bronchodilators.
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Role of muscarinic antagonists in asthma therapy
Expert Review of Respiratory Medicine, 2017Higher parasympathetic tone has been reported in asthmatics. In general, cholinergic contractile tone is increased by airway inflammation associated with asthma. Nevertheless, the role of muscarinic antagonists for the treatment of asthma has not yet been clearly defined.
CAZZOLA, MARIO +3 more
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Selective muscarinic receptor antagonists for airway diseases
Current Opinion in Pharmacology, 2001Airway tone and airway hyperreactivity are mediated by the parasympathetic nerves that release acetylcholine onto muscarinic receptors (M1-M5). Stimulation of M1 and M3 muscarinic receptors causes bronchoconstriction. The M1 muscarinic receptor is excitatory, and facilitates neuronal transmission at the parasympathetic ganglion.
A M, Lee, D B, Jacoby, A D, Fryer
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Muscarinic Antagonists for Myopia Control
1998Previous nonsurgical treatment of myopia using optical and pharmaceutical agents has not allowed an unequivocal consensus. Such studies must be based on the natural history of myopia progression, accurate biometric measurements, and randomized clinical trials.
Sek-Jin Chew +3 more
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