Results 91 to 100 of about 578,217 (295)

PRS27 COST-EFFECTIVENESS OF FIX-DOSE COMBINATIONS OF LONG-ACTING Β AGONIST PLUS LONG-ACTING MUSCARINIC ANTAGONIST (LABA/LAMA) FOR THE TREATMENT OF COPD: A SYSTEMATIC REVIEW [PDF]

, 2020
L. Wang, H. Li, Siqing Fu, X. Zhang, D. Zhang, Andrew Ma   +5 more
openalex   +1 more source

Natural History of Airway Hyperresponsiveness and Its Association With Asthma Traits

Allergy, EarlyView.
AHR improves in most children over adolescence when its relationship with asthma changes. AHR is better at ruling out asthma in children, while it is superior at ruling in asthma in young adults. Age should be considered when interpreting AHR, and different cutoffs might be required for children and adults.
Sophie Carra, Hongmei Zhang, Ramesh J. Kurukulaaratchy, Syed Hasan Arshad   +3 more
wiley   +1 more source

ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS [PDF]

, 1980
David A. Brown, A. FORWARD, S. Marsh
openalex   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Bianchi C, Broad RM, Buchheit KH, Budhoo MR, Carter D, Costall B, Costa M, Craig DA, D'Amato M, Eglen RM, Engel G, Erspamer V, Feldberg W, Gale JD, Gebauer A, Gershon MD, Gozlan H, Hedge SS, Hume SP, Humphrey PP, Ivancheva C, Javid FA, Kilbinger H, Kuemmerle JF, Leysen JE, Malleron JL, Mawe GM, Nowak TV, Pan H, Racke K, Radomirov R, Satoh Y, Weber LJ, Yamamoto I   +33 more
core   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Effect of the Arg16Gly β2‐Adrenergic Receptor Polymorphism on Long‐Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype‐Stratified, Multicenter Study

Allergy, EarlyView.
This study examines the association between the rs1042713 (Arg16Gly) polymorphism of the β2‐adrenergic receptor and the risk of severe eosinophilic asthma, as well as its influence on mepolizumab long‐term effectiveness and clinical remission. The Arg16 allele is associated with increased risk of severe disease and potentially diminished long‐term ...
Santi Nolasco, Evelina Fagone, Raffaele Campisi, Andrea Portacci, Giulia Scioscia, Corrado Pelaia, Angelantonio Maglio, Claudio Candia, Vitaliano Nicola Quaranta, Isabella Carrieri, Alessandro Saglia, Alessandro Vatrella, Girolamo Pelaia, Carlo Vancheri, Maria Pia Foschino Barbaro, Maria D'Amato, Giovanna Elisiana Carpagnano, Nunzio Crimi, Claudia Crimi, on behalf of the Southern Italy Network on Severe Asthma Therapy, Rossella Intravaia, Morena Porto, Pietro Impellizzeri, Maria Provvidenza Pistorio, Fabio Vignera, Andrea Alessia Nardo, Concetta Giannì, Silvano Dragonieri, Flogerta Sana, Valeria Pezzuto, Santina Ferulli, Massimo Triggiani, Roberta Parente, Pasquale Tondo, Piera Soccio, Donato Lacedonia, Luigi Ciampo, Antonio Franzese, Valeria Longobardi   +38 more
wiley   +1 more source

EFFECTS OF CERTAIN MUSCARINIC ANTAGONISTS ON THE ACTIONS OF ANTICHOLINESTERASES ON CAT SKELETAL MUSCLE [PDF]

, 1979
R.W. Brimblecombe, Mary C. French, Sandra N. Webb   +2 more
openalex   +1 more source

Efficacy of revefenacin, a long-acting muscarinic antagonist for nebulized therapy, in patients with markers of more severe COPD: a post hoc subgroup analysis [PDF]

, 2020
James F. Donohue, Edward Kerwin, Chris N. Barnes, Edmund J. Moran, Brett Haumann, Glenn Crater   +5 more
openalex   +1 more source

Cluster Analysis to Identify Distinct Asthma Phenotypes in the ATLANTIS Cohort

Allergy, EarlyView.
This study identified four clinically distinct asthma clusters. The most severe cluster was characterized by type 2 inflammation and exhibited both large and small airways obstruction, as well as air trapping on CT. Patients in the earlier‐onset cluster exhibited more severe bronchial hyperresponsiveness despite a relatively preserved lung function ...
Pauline J. M. Kuks, Tatiana Karp, Jorine E. Hartman, Monica Kraft, Salman Siddiqui, Leonardo M. Fabbri, Bianca Beghé, Klaus F. Rabe, Alberto Papi, Christopher E. Brightling, Dave Singh, Xingnan Li, Janwillem W. H. Kocks, Ulrica Scaffidi‐Argentina, Huib A. M. Kerstjens, Irene H. Heijink, Simon D. Pouwels, Dirk‐Jan Slebos, Maarten van den Berge   +18 more
wiley   +1 more source

Addition of long-acting beta2 agonists or long-acting muscarinic antagonists versus doubling the dose of inhaled corticosteroids (ICS) in adolescents and adults with uncontrolled asthma with medium dose ICS: a systematic review and network meta-analysis. [PDF]

Cochrane Database Syst Rev, 2023
Oba Y, Anwer S, Patel T, Maduke T, Dias S.   +4 more
europepmc   +1 more source