Results 91 to 100 of about 22,691 (214)

Antagonistic AI [PDF]

arXiv
The vast majority of discourse around AI development assumes that subservient, "moral" models aligned with "human values" are universally beneficial -- in short, that good AI is sycophantic AI. We explore the shadow of the sycophantic paradigm, a design space we term antagonistic AI: AI systems that are disagreeable, rude, interrupting, confrontational,
arxiv  

Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat [PDF]

, 1990
Carlo Polidori, Maurizio Massi, Günter Lambrecht, E. Mutschler, Reinhold Tacke, Carlo Melchiorre   +5 more
openalex   +1 more source

Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects

Mediators of Inflammation, 2012
Muscarinic receptors are expressed by most cell types and mediate cellular signaling of their natural ligand acetylcholine. Thereby, they control numerous central and peripheral physiological organ responses to neuronal activity.
George Karakiulakis, Michael Roth
doaj   +1 more source

The effect of allosteric antagonists in modulating muscarinic M₂‐receptor function in guinea‐pig isolated trachea [PDF]

, 1994
Domenico Spina, Eleanor Minshall, R.G. Goldie, Clive P. Page   +3 more
openalex   +1 more source

The reasons for triple therapy in stable COPD patients in Japanese clinical practice

International Journal of COPD, 2015
Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio ...
Miyazaki M, Nakamura H, Takahashi S, Chubachi S, Sasaki M, Haraguchi M, Terai H, Ishii M, Fukunaga K, Tasaka S, Soejima K, Asano K, Betsuyaku T   +12 more
doaj  

Differential regulation of human cardiac beta‐adrenergic and muscarinic receptors by chronic beta‐adrenoceptor antagonist treatment. [PDF]

, 1990
Shigeru Motomura, NM Deighton, HR Zerkowski, Massud Khamssi, O‐E Brodde   +4 more
openalex   +1 more source

A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions

Cell Reports, 2019
Summary: Lymphatic vessels (LVs) are important in the regulation of tissue fluid homeostasis and the pathogenesis of tumor progression. We investigated the innervation of LVs and the response to agonists and antagonists of the autonomic nervous system in 
Samia B. Bachmann, Denise Gsponer, Javier A. Montoya-Zegarra, Martin Schneider, Felix Scholkmann, Carlotta Tacconi, Simon F. Noerrelykke, Steven T. Proulx, Michael Detmar   +8 more
doaj  

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj  

Functional Activation of G-Proteins Coupled With Muscarinic Acetylcholine Receptors in Rat Brain Membranes

Journal of Pharmacological Sciences, 2014
.: The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding assay in rat brain membranes.
Yuji Odagaki, Masakazu Kinoshita, Ryoichi Toyoshima   +2 more
doaj  

A Random Forest-based Prediction Model for Turning Points in Antagonistic Event-Group Competitions [PDF]

arXiv
At present, most of the prediction studies related to antagonistic event-group competitions focus on the prediction of competition results, and less on the prediction of the competition process, which can not provide real-time feedback of the athletes' state information in the actual competition, and thus can not analyze the changes of the competition ...
arxiv