Results 101 to 110 of about 25,052 (251)

Novel muscarinic antagonists designed on the 1,4-dioxane scaffold

, 2010
The five subtypes of muscarinic receptors (M1-M5) are widely distributed on multiple organs and tissues and are critical to the maintenance of central and peripheral cholinergic neurotrasmission.
PIERGENTILI, Alessandro, A. Farande, R. Matucci, M. Nesi, GIANNELLA, Mario, PIGINI, Maria, QUAGLIA, Wilma, DEL BELLO, FABIO   +7 more
core  

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

Positioning new pharmacotherapies for COPD

International Journal of COPD, 2015
Igor Z Barjaktarevic,1 Anthony F Arredondo,1 Christopher B Cooper1,2 1Department of Medicine, 2Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA Abstract: COPD imposes ...
Barjaktarevic IZ, Arredondo AF, Cooper CB   +2 more
doaj  

Inhaled corticosteroids with combination inhaled long-acting beta2-agonists and long-acting muscarinic antagonists for chronic obstructive pulmonary disease. [PDF]

Cochrane Database Syst Rev, 2023
van Geffen WH, Tan DJ, Walters JA, Walters EH.   +3 more
europepmc   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Muscarinic receptor subtypes - search for selective agonists and antagonists

, 1996
Since the late eighties five muscarinic receptor subtypes (m1 - m5) have been cloned and four of them (M1 - M4) have also been pharmacologically characterized. However, there is still a lack of potent muscarinic agonists and antagonists, which are highly
Gross, Jan, Mendla, Klaus, Tacke, Reinhold, J. Gross, E. Mutschler, D. Reichel, K. Mendla, Rühlmann, K., J. Wehrle, U. Moser, Lambrecht, Günter, K. Rühlmann, M. Waelbroeck, Waelbroeck, Magali, Ensinger, Helmut H.A., O. Pfaff, Moser, Ulrich, Reichel, Dirk, R. Tacke, A. Leis, Mutschler, Ernst, Leis, Albrecht, Pfaff, Otmar, Wehrle, Jahn, H.A. Ensinger, G. Lambrecht   +25 more
core   +1 more source

Renewed perspective on efficacy and safety of inhaled muscarinic antagonists as asthma management therapies [PDF]

, 2021
Background: Although muscarinic antagonists are currently used to treat asthma, there remain various characteristics that have yet to be fully elucidated.
Cropper, Kayla J
core  

Differential pharmacology and clinical utility of emerging combination treatments in the management of COPD – role of umeclidinium/vilanterol

International Journal of COPD, 2014
Mario Malerba,1 Jaymin Bhagwanji Morjaria,2 Alessandro Radaeli3 1Department of Internal Medicine, University of Brescia, Brescia, Italy; 2Department of Academic Respiratory Medicine, Hull York Medical School, University of Hull, Castle Hill Hospital ...
Malerba M, Morjaria JB, Radaeli A
doaj  

Muscarinic antagonists impair multiple aspects of operant discrimination learning and performance. [PDF]

Neurosci Lett, 2023
Yousuf H, Girardi EM, Crouse RB, Picciotto MR.   +3 more
europepmc   +1 more source

HETEROGENEOUS RECEPTOR-BINDING OF CLASSICAL QUATERNARY MUSCARINIC ANTAGONISTS .1. BOVINE TISSUE DISTRIBUTION

, 1991
In competition experiments with the teritiary radioligand [H-3]dexetimide, classical quaternary muscarinic antagonists like ipratropium bromide and N-methylscopolamine bromide distinguished two muscarinic binding sites in bovine brain (total brain minus ...
ROFFEL, AF, INTHOUT, WG, ZAAGSMA, J, DEZEEUW, RA, ENSING, K   +4 more
core   +1 more source