Results 91 to 100 of about 25,052 (251)
M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation
World Allergy Organization Journal, 2013 Airways chronic inflammatory conditions in asthma and COPD are characterized by tissue remodeling, being smooth muscle hyperplasia, the most important feature.
Fabiola A. Placeres-Uray +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi +10 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley +1 more source
, 1991 The heterogeneous binding behavior exhibited by classical quaternary muscarinic antagonists was further investigated in order to establish possible molecular and/or environmental differences between the high (Q1) and low (Q2) affinity binding sites ...
ROFFEL, AF +6 more
core +1 more source
Muscarinic Receptor Antagonists: Effects on Pulmonary Function [PDF]
, 2011 In healthy lungs, muscarinic receptors control smooth muscle tone, mucus secretion, vasodilation, and inflammation. In chronic obstructive pulmonary disease (COPD) and asthma, cholinergic mechanisms contribute to increased bronchoconstriction and mucus secretion that limit airflow.
Kalmia S, Buels, Allison D, Fryer
openaire +2 more sources
Case report : Acute unintentional carbachol intoxication
, 2006 Introduction: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning.
Schulz, Martin +5 more
core +1 more source
Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma? [PDF]
Drugs, 2023 Cazzola M, Rogliani P, Matera MG.
europepmc +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Inhaled long-acting muscarinic antagonists in chronic obstructive pulmonary disease
, 2011 In 2002, the first long-acting muscarinic antagonist, tiotropium bromide (Spiriva®), was launched as a once-daily bronchodilating agent for the treatment of chronic obstructive pulmonary disease.
Jakob Busch-Petersen, Dramane I Lainé
core +1 more source
International Journal of COPD, 2018 Mohamed Ismail Abdul Aziz,1,* Ling Eng Tan,1,* David Bin-Chia Wu,1 Fiona Pearce,1 Gerald Seng Wee Chua,2 Liang Lin,1 Ping-Tee Tan,1 Kwong Ng1 1Agency for Care Effectiveness, Ministry of Health, Singapore; 2Division of Medicine, Ng Teng Fong General ...
Abdul Aziz MI +7 more
doaj