Results 121 to 130 of about 149,769 (206)

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

synthesis and pharmacological characterization of silicon-containing muscarinic antagonists, dopamine receptor antagonists, Ca2+ channel blockers, and alpha1-adrenoceptor antagonists

, 2004
Im Rahmen der vorliegenden Arbeit wurden neuartige siliciumhaltige Muscarinrezeptor-Antagonisten, Dopaminrezeptor-Antagonisten, Ca2+-Kanal-Blocker sowie alpha1-Rezeptor-Antagonisten synthetisiert, welche Sila-Analoga (C/Si-Austausch) bekannter ...
Heinrich, Tilman
core   +2 more sources

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure

, 2010
Starting from the structure of previously studied muscarinic agonists, characterized by a pyrrolidinylfuran scaffold, a new series of muscarinic antagonists was synthesized by substituting the 5-position of the furane cycle with bulky hydrophobic groups.
Teodori E., Romanelli M. N., Guandalini L., Orlandi F., BUCCIONI, Michela, Manetti D., Bellucci C., Nesi M., Matucci R., Martini E., Scapecchi S., Martelli C., MARUCCI, Gabriella, Dei S., Cirilli R.   +14 more
core   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Synthesis of antagonists of muscarinic (M3) receptors

, 2011
Several α-hydroxyamides with (2,6-dialkoxyphenoxy)methyl substituents have been prepared and their activities as antagonists of the M3 muscarinic receptor in guinea pig ileum have been evaluated.
Thomas, Eric J., Eric J. Thomas, Penson, Peter, Broadley, Kenneth John, Penson, Peter Edward, Lee, Alan T. L., Davies, Robin H., Lee, Alan T L, Christine Escargueil, Peter Penson, Broadley, Kenneth J., Escargueil, Christine, Kenneth J. Broadley, Robin H. Davies, Alan T. L. Lee   +14 more
core   +1 more source

Mechanisms reducing parasympathetic activity in chronic hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Parasympathetic activity is reduced in chronic hypoxia, but the underlying mechanism(s) are unclear. Using β‐adrenergic blockade to isolate parasympathetic control of heart rate at sea level and after 9‐12 days at high altitude, we investigated whether (i) chemoreflex activation, (ii) increased pulmonary ventilation and/or (iii ...
Lauren E. Maier, Andrew Douglas, Katharine Foster, Elliott J. Jenkins, Liam D. Corr, Peter Rasmussen, James Anholm, Travis D. Gibbons, Phil N. Ainslie, Mike Stembridge, Christoph Siebenmann   +10 more
wiley   +1 more source

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

The Journal of Physiology, EarlyView.
Abstract figure legend In the muscular layer of long‐standing diabetic bladders increased myostatin expression promotes tissue remodelling by reducing the muscle‐to‐collagen ratio, ultimately diminishing bladder contractility. Maximal elastance – defined as the slope of the end‐emission pressure–volume relationship (EPR), derived from the regression ...
Cheng‐Yuan Lai, Hui‐Hsuan Lau, Ming‐Chun Hsieh, Hsien‐Yu Peng, Dylan Chou, Tsung‐Hsien Su, Tzer‐Bin Lin   +6 more
wiley   +1 more source

Envolvimento do receptor NMDA de glutamato na ansiedade experimental induzida pela pilocarpina [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.A ansiedade é vista pela ciência moderna como um conjunto de comportamentos, com respostas ...
Oliveira, Alanny Bahia de
core  

Real‐World Management of Difficult Exacerbations of Bronchiectasis: A Case Study to Illustrate How Guidelines Can Support Best Practice

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Timely management of exacerbations and optimisation of ongoing care are vital in preventing disease progression and preserving outcomes and quality of life in patients with bronchiectasis. This retrospective case review underscores the importance of the new ERS guidelines in supporting multidisciplinary teams to provide optimal care for their ...
Hulance Bianca, Capstick Toby, Shah Anand, McCallion Paul   +3 more
wiley   +1 more source