Long-Acting Muscarinic Antagonists for the Treatment of Difficult-to-Treat and Severe Asthma: A Narrative Review Focusing on Inflammation from Bench to Bedside. [PDF]
J Inflamm ResCalzetta L +6 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Use of long-acting muscarinic antagonists for severe asthma: insights from clinicians in the SHARP network. [PDF]
Respir ResMarcon A +11 more
europepmc +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, Volume 293, Issue 16, Page 4789-4804, August 2026.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Long-acting muscarinic antagonists for the treatment of asthma in children-a new kid in town. [PDF]
Allergo J Int, 2018 Hamelmann E.
europepmc +1 more source
Managing Asthma Well and Sustainably – Patient Perspectives Explored
Health Expectations, Volume 29, Issue 4, August 2026.ABSTRACT Context Asthma affects 300 million people worldwide. The widespread use of short‐acting beta2‐agonist (SABA) relievers, commonly delivered via pressurised metered dose inhalers (pMDIs), is contrary to evidence‐based guidelines. SABA overuse is associated with poor asthma control and high carbon emissions.
Imogen Le Couteur +7 more
wiley +1 more source
Positioning of Long-Acting Muscarinic Antagonists in the Management of Asthma. [PDF]
Allergy Asthma Immunol Res, 2017 Aalbers R, Park HS.
europepmc +1 more source
Management of Paediatric Acute Asthma in a Metropolitan Emergency Department: A Retrospective Audit
Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1394-1402, August 2026.ABSTRACT Aim To evaluate adherence to the Sydney Children's Hospital Network (SCHN) Asthma‐Acute Management Practice Guideline in the management of paediatric patients presenting to a metropolitan emergency department (ED). Methods A cross‐sectional retrospective audit of 153 paediatric ED presentations with acute asthma between March 2023 and February
Yasmine Toufaili, Nounu Sarukkali
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Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation
The Journal of Physiology, Volume 604, Issue 16, Page 6872-6894, 15 August 2026.Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson +7 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 15, Page 6348-6368, 1 August 2026.Abstract figure legend Physiological functions of PKD1, a large transmembrane polycystin protein, are unclear. Previous results obtained using germline non‐specific knockout mice suggested that PKD1 regulates arterial smooth muscle cell contractility.
Angélica K. Bernardelli +7 more
wiley +1 more source