Results 131 to 140 of about 149,769 (206)

The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity‐Related and Alcohol‐Seeking Behaviors

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Adolescent impulsivity is linked to increased alcohol seeking and altered activation of anterior insular PV interneurons. Chemogenetic modulation of these neurons regulates inhibitory control and alcohol‐related behaviors, highlighting their role in vulnerability to alcohol use disorder.
F. Bezerra, G. J. D. Fernandes, A. Anjos‐Santos, C. A. Favoretto, B. T. Rodolpho, P. Palombo, V. Vialou, K. P. Abrahao, F. C. Cruz   +8 more
wiley   +1 more source

Müller Glia–Vasculature Interactions in the Developing Retina

Glia, Volume 74, Issue 10, October 2026.
Retinal vascular layers form normally despite loss of cholinergic retinal waves. Müller glial processes contact endothelial tip cells early and form Aquaporin‐4‐enriched endfeet. Glial endfoot calcium signals are compartmentalized and occur largely independently of neural activity. ABSTRACT Coordinated signaling among neurons, glia, and the vasculature
Samira Monshietehadi, Angel J. Garcia, Benjamin E. Smith, Matthew Tarchick, Kiara Abhayaratne, Aileen Conley, Marla B. Feller   +6 more
wiley   +1 more source

Structure-activity guided design of novel long-acting antagonists of muscarinic receptors

Given the broad range of functions that muscarinic receptors subserve, it is of fundamental importance to find subtype-selective ligands for therapeutic use in specific disorders.
Jan Korabecny
core   +1 more source

The Clinical Characteristic and Prognostic Value of Frailty in Elderly COPD Patients

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background and Objective Frailty, as one of the extrapulmonary comorbidities of chronic obstructive pulmonary disease (COPD), is highly prevalent in COPD patients. The primary objective of this research was to assess how frailty influences subsequent exacerbation and augments the predictive capacity of dyspnoea or the exacerbation history ...
Tao Li, Ping Zhang, Qing Song, Cong Liu, Ling Lin, Yuqin Zeng, Ping Chen   +6 more
wiley   +1 more source

SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NEW CHIRAL MUSCARINIC ANTAGONISTS

, 1995
The two pairs of enantiomers of isoxazolidin-3-ones 3 and 4 were synthesized by means of Lipase PS-catalyzed hydrolyses of suitable racemic butyrates.
M. De Amici, C. De Micheli, M. Carnielli, C. Boselli, M. Zacchigna, E. Grana, V. Maurich, T. Gianferrara   +7 more
core   +2 more sources

Barriers to achieving asthma control in adults: evidence for the role of tiotropium in current management strategies

Therapeutics and Clinical Risk Management, 2019
Christine Jenkins Department of Thoracic Medicine, The George Institute for Global Health and Concord Clinical School, University of Sydney, Sydney, NSW, Australia Abstract: Despite the availability of a range of treatment options and management ...
Jenkins C
doaj  

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

Improvements With Tiotropium Maintenance Therapy in COPD Patients Without Dyspnea

MedComm, Volume 7, Issue 10, October 2026.
In a post hoc analysis of the Tie‐COPD trial, including 305 patients with mild‐to‐moderate COPD and no dyspnea (mMRC 0), 2 years of tiotropium improved lung function, lowered the annual exacerbation rate, and delayed the first clinically important deterioration, indicating benefit beyond symptom relief in a group not currently offered maintenance ...
Zihui Wang, Junfeng Lin, Guannan Cai, Fan Wu, Zhishan Deng, Qi Wan, Gaoying Tang, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Xiaohui Wu, Suyin Huang, Fangyan Wu, Nanshan Zhong, Yumin Zhou, Pixin Ran   +15 more
wiley   +1 more source

Profile of a fixed-dose combination of tiotropium/olodaterol and its potential in the treatment of COPD

International Journal of COPD, 2015
Sanjeevan Muruganandan,1 Lata Jayaram2,3 1Department of Respiratory and Sleep Medicine, Austin Health, 2Department of Respiratory and Sleep Medicine, Western Health, 3University of Melbourne, Melbourne, Victoria, Australia Abstract: Chronic obstructive
Muruganandan S, Jayaram L
doaj  

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source