FASEB BioAdvances, Volume 7, Issue 11, November 2025.Pilocarpine activates M1 and M3 muscarinic receptors in porcine ciliary muscle, engaging calcium‐dependent phospholipase C (PLC), nitric oxide synthase (NOS), and cyclooxygenase (COX) pathways that increase prostaglandin E2 (PGE2) synthesis. Beyond nitric oxide (NO) modulation, PGE2 emerges as a key mediator linking muscarinic signaling to ciliary ...
Giovanna Benozzi +3 more
wiley +1 more source
Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power
Acta Ophthalmologica, Volume 103, Issue 7, Page e511-e523, November 2025.Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi +8 more
wiley +1 more source
Sleep-Predominant Lowering of Ambulatory Blood Pressure by Bedtime Inhalation of a Novel Muscarinic M3 Receptor Antagonist: A New “Bronchoantihypertensive” Strategy Targeting the Lung in Hypertension with Chronic Obstructive Pulmonary Disease [PDF]
, 2008 Kazuomi Kario +2 more
openalex +1 more source
inhibitor 2-[(4-methylphenyl)sulfonylcarbamido]-1-(4-nitrobenzyl)pyridinium bromide (2-AP27) is a muscarinic M2 receptor antagonist [PDF]
, 2009 Vytenis Arvydas Skeberdis +4 more
openalex +1 more source
Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction
Acta Physiologica, Volume 241, Issue 11, November 2025.ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the primary cause of death in opioid overdose, resulting from both suppressed respiratory rhythm and increased airway and thoracic rigidity that compromise ventilation and resuscitation. While the effect(s) of opioids on central rhythm‐generating circuits are well documented, the mechanisms ...
Riley R. Parks +3 more
wiley +1 more source
A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning [PDF]
, 2009 Douglas J. Sheffler +14 more
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 21, Page 5286-5302, November 2025.Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades +4 more
wiley +1 more source
Long-acting muscarinic antagonists for the treatment of asthma in children-a new kid in town. [PDF]
Allergo J Int, 2018 Hamelmann E.
europepmc +1 more source
Activity of aclidinium bromide, a new long‐acting muscarinic antagonist: a phase I study [PDF]
, 2010 Vanessa Schelfhout +6 more
openalex +1 more source
Neurogastroenterology &Motility, Volume 37, Issue 11, November 2025.In a parallel, placebo‐controlled study with direct gas infusion into the stomach, STW 5‐II reduced the perception of abdominal symptoms in patients with dyspepsia complaining of bloating when compared to placebo, with a minor effect on gas transit and evacuation, and no effect on visible abdominal distension.
Ariadna Aguilar +6 more
wiley +1 more source