Results 151 to 160 of about 578,217 (295)

Residual Effects of Acute and Subchronic Zolpidem Treatments on Attentional Processes in Aged Female Rats

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Rational Zolpidem, a hypnotic Z‐drug commonly prescribed to promote sleep, is predominantly used over the age of 50. In this elderly population, adverse behavioral disturbances, impaired driving performance, and an increased risk of falls have been frequently reported.
Marianne Leger, Michel Boulouard, Christophe Liet, Ben Grayson, Michael Harte, Joanna C. Neill, Marie‐Laure Bocca, Véronique Lelong‐Boulouard   +7 more
wiley   +1 more source

Use of long-acting muscarinic antagonists for severe asthma: insights from clinicians in the SHARP network. [PDF]

Respir Res
Marcon A, Martinelli L, Bansal AT, Berret E, Bossios A, Marchetti P, Porsbjerg C, Principe S, Schleich F, Sergejeva S, Sont JK, Caminati M.   +11 more
europepmc   +1 more source

Effects of Muscarinic Receptor Antagonists With or Without M2 Antagonist Activity on Cholinergic Reflex Bronchoconstriction in Ovalbumin-Sensitized and -Challenged Mice

, 2003
Hiroyasu Hirose, Jian Jiang, Masaru Nishikibe   +2 more
openalex   +2 more sources

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang, Qingyu Zhao, Qingfeng Zhang, Xiaofeng Wu, Xu Liu, Shujuan Wu, Hailing Liu, Beini Zhou, Shiqian Zha, Dong Zhao, Gang Deng, Ke Hu   +11 more
wiley   +1 more source

Long-acting muscarinic antagonists for the treatment of asthma in children-a new kid in town. [PDF]

Allergo J Int, 2018
Hamelmann E.
europepmc   +1 more source

Involvement of Ca2+ Signaling in the Synergistic Effects between Muscarinic Receptor Antagonists and β2-Adrenoceptor Agonists in Airway Smooth Muscle [PDF]

, 2016
Kentaro Fukunaga, Hiroaki Kume, Tetsuya Oguma, Wataru Shigemori, Yuji Tohda, Emiko Ogawa, Yasutaka Nakano   +6 more
openalex   +1 more source

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

BioEssays, Volume 47, Issue 12, December 2025.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi, Paul R. Gooley, Thomas R. Weikl   +2 more
wiley   +1 more source

Long-acting muscarinic receptor antagonists for the treatment of chronic airway diseases

Therapeutic Advances in Chronic Disease, 2014
K. Alagha, A. Palot, T. Sofalvi, L. Pahus, M. Gouitaa, C. Tummino, S. Martinez, D. Charpin, A. Bourdin, P. Chanez   +9 more
semanticscholar   +1 more source

Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity

Ibrain, Volume 11, Issue 4, Page 403-421, Winter 2025.
Synaptic adhesion molecules (SAM) are essential for the formation, maturation, function, plasticity, and assembly of synaptic connections, all critical for normal neurodevelopment. Excessive exposure to neurotoxic metals during development could disrupt the developing brain and potentially lead to neurodevelopmental disorders (NDDs).
Toheeb O. Oyerinde, Victor E. Anadu, Tobiloba S. Olajide, Ileje I. Ukwubile, Olayemi K. Ijomone, Kingsley A. Iteire, Michael Aschner, Omamuyovwi M. Ijomone   +7 more
wiley   +1 more source

Effectiveness and Safety of Dupilumab Monotherapy in Japanese Patients With Chronic Rhinosinusitis With Nasal Polyps

The Laryngoscope, Volume 135, Issue 12, Page 4625-4632, December 2025.
In this phase 4, open‐label, single‐arm, multicenter study, dupilumab monotherapy was associated with reductions from baseline to week 24 (primary endpoint) in the bilateral endoscopic Nasal Polyp Score (NPS) in 25 Japanese adults with inadequately controlled chronic rhinosinusitis with nasal polyps on standard care therapies.
Shigeharu Fujieda, Tetsuji Takabayashi, Nobuo Ohta, Mamoru Yoshikawa, Yuki Kibe, Masato Ishida, Katsuhisa Suzuki, Yoshinori Takahashi, Nikhil Amin, Lakiea Wright, Lacey Robinson, Kenji Yahata   +11 more
wiley   +1 more source