Results 91 to 100 of about 55,054 (301)

Oral Health in Individuals with Severe Mental Illness on Second‐Generation Antipsychotics—A Scoping Review

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Introduction There has been a significant increase in antipsychotic usage, particularly belonging to second‐generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear.
Dileep Sharma, Oliver Higgins, Aleksander Sawicki, Poornima Ramamurthy, Belinda Field, Paul Hussein, Kiran Singh, Sarbin Ranjitkar   +7 more
wiley   +1 more source

Maternal consumption of a high-fat diet modulates the inflammatory response in their offspring, mediated by the M1 muscarinic receptor. [PDF]

Front Immunol, 2023
Costa SO, Chaves WF, Lopes PKF, Silva IM, Burguer B, Ignácio-Souza LM, Torsoni AS, Milanski M, Rodrigues HG, Desai M, Ross MG, Torsoni MA.   +11 more
europepmc   +1 more source

Muscarinic receptors in the rat cerebellum. Characteristics and methodology [PDF]

, 1979

openalex   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia. [PDF]

Sci Rep, 2023
Cheng K, Chahdi A, Larabee SM, Tolaymat M, Sundel MH, Drachenberg CB, Zhan M, Hu S, Said AH, Shang AC, Xie G, Alizadeh M, Moura NS, Bafford AC, Williams RT, Hanna NN, Raufman JP.   +16 more
europepmc   +1 more source

ANTAGONIST DISCRIMINATION BETWEEN GANGLIONIC AND ILEAL MUSCARINIC RECEPTORS [PDF]

, 1980
David A. Brown, A. FORWARD, S. Marsh
openalex   +1 more source

Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction

Neurogastroenterology &Motility, EarlyView.
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley   +1 more source

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. [PDF]

Elife, 2023
Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Nawaratne V, Leach K, van der Westhuizen ET, Khajehali E, Liang YL, Glukhova A, Wootten D, Lindsley CW, Tobin A, Sexton P, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM.   +23 more
europepmc   +1 more source

Effects of temperature and ethanol on agonist and antagonist binding to rat heart muscarinic receptors in the absence and presence of GTP [PDF]

, 1985
Magalì Waelbroeck, Patrick Robberecht, Pierre Chatelain, Philippe De Neef, Jean Christophe   +4 more
openalex   +1 more source

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, EarlyView.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source