Results 61 to 70 of about 56,565 (298)
Intratumoral Nerve Phased Development: A Promising Therapeutic Target
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che+3 more
wiley +1 more source
Muscarinic modulation of M and h currents in gerbil spherical bushy cells.
Descending cholinergic fibers innervate the cochlear nucleus. Spherical bushy cells, principal neurons of the anterior part of the ventral cochlear nucleus, are depolarized by cholinergic agonists on two different time scales.
Charlène Gillet+2 more
doaj +1 more source
This study demonstrated significant treatment efficacy and safety of incobotulinumtoxinA injection in Japanese patients with chronic sialorrhea caused by Parkinson's disease and other neurological conditions. Suppression of salivary secretion and improvement in drooling symptoms were also observed throughout 48 weeks.
Nobutaka Hattori+15 more
wiley +1 more source
Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle
Background Acetylcholine, the primary parasympathetic neurotransmitter in the airways, plays an important role in bronchoconstriction and mucus production.
Zuyderduyn Suzanne+8 more
doaj +1 more source
Abstract Objectives Levodopa treatment, the gold standard therapy for Parkinson's disease, can lead to levodopa‐induced dyskinesias (LIDs). Recent studies in acute brain slices have implicated the neural dynamics of striatal cholinergic interneurons (CINs) in the pathophysiology of LID, reporting that their discharge becomes more bursty in dyskinetic ...
Yara Atamna+6 more
wiley +1 more source
Lung cancer is the leading cause of cancer death worldwide and new treatment strategies are clearly needed. The recent discovery that lung and other cancers synthesize and secrete acetylcholine (ACh) which acts as an autocrine growth factor suggests that
Therapy Pingfang Song, Eliot R. Spindel
doaj +1 more source
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Lachlan Churchill+6 more
wiley +1 more source
ABSTRACT Introduction Abdominal distension is an objective visible sign of increased abdominal girth. Bloating is a feeling of abdominal fullness and discomfort. Bloating may be associated or not with abdominal distension. Bloating and abdominal distension are among the most commonly reported gastrointestinal symptoms and may be associated with both ...
Chloé Melchior+20 more
wiley +1 more source
Autoradiography helps to determine the distribution and density of muscarinic receptor (MR) binding sites in the brain. However, it relies on the selectivity of radioligands toward their target.
Paulina Valuskova+4 more
doaj +1 more source
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, mainly due to its aggressive nature, early metastasis, diagnosis at late stages, and limited response to systemic anticancer therapy. Perineural invasion (PNI), defined as the infiltration of neoplastic cells along nerve fibers and within nerve sheaths, is ...
Martin Lovecek+10 more
wiley +1 more source