Results 71 to 80 of about 55,054 (301)

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, EarlyView.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source

Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration

Journal of Pharmacological Sciences, 2019
The present study aimed to characterize muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine (5-HMT), and tolterodine in bladder and other tissues of rats after their oral, intravenous, or intravesical administration.
Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Yoshihisa Kato, Satomi Onoue   +4 more
doaj  

POTENTIATION OF NERVE‐INDUCED BLADDER RESPONSES BY TETRAETHYLAMMONIUM IN RELATION TO JUNCTIONAL AND EXTRAJUNCTIONAL MUSCARINIC RECEPTORS [PDF]

, 1978
F. G. Carpenter
openalex   +1 more source

Developing an international concept‐based curriculum for pharmacology education: The promise of core concepts and concept inventories

British Journal of Clinical Pharmacology, EarlyView.
Abstract Over recent years, studies have shown that science and health profession graduates demonstrate gaps in their fundamental pharmacology knowledge and ability to apply pharmacology concepts in practice. This article reviews the current challenges faced by pharmacology educators, including the exponential growth in discipline knowledge and ...
Clare Guilding, Roisin Kelly‐Laubscher, Adeladlew Netere, Anna‐Marie Babey, Carolina Restini, Margaret Cunningham, John P. Kelly, Jennifer Koenig, Kelly Karpa, Martin Hawes, Steven J. Tucker, Thomas A. Angelo, Paul J. White   +12 more
wiley   +1 more source

Revefenacin: Drug review

Journal of Clinical and Biomedical Sciences, 2018
Revefenacin, a long-acting muscarinic receptor antagonist was approved by US Food and Drug Administration in November 2018 for the maintenance treatment of patients with Chronic Obstructive Pulmonary Disease (COPD).
Bhuvana K
doaj   +1 more source

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

British Journal of Pharmacology, EarlyView.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia, Belén Climent, Bianca Barreira, Daniel Morales‐Cano, Ana Sánchez, Argentina Fernández, Borja García‐Gómez, Javier Romero‐Otero, Claudia Rodríguez, Laura Moreno, Dolores Prieto, María Jesús Larriba, Angel Cogolludo, Javier Angulo, Francisco Perez‐Vizcaino   +14 more
wiley   +1 more source

The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents [PDF]

, 1977
Daniel Cavey, Jean‐Pierre Vincent, Michel Lazdunski   +2 more
openalex   +1 more source

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

The Effect of Oral Antihistamines on the Sweating Response During Heat Stress in Adults

Allergy, EarlyView.
Douglas Newhouse, Taryn Klarner, Mario Nucci, Nicholas Ravanelli   +3 more
wiley   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source