Results 151 to 160 of about 85,643 (234)

Deceptive beauty of non‐natural structures

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Structures of proteins and multiprotein complexes are considered landmark achievements. However, in many cases, mutant proteins are used for structural work. Even when wild type proteins are used, crystallization or complex formation for cryoEM is performed in highly nonphysiological conditions.
Vsevolod V. Gurevich, Eugenia V. Gurevich   +1 more
wiley   +1 more source

Vasorelaxant Effect of Moroccan Cannabis sativa Threshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent. [PDF]

Evid Based Complement Alternat Med, 2023
Mahou Y, Chda A, Es-Safi NE, Tesse A, Fettoukh N, El Bouri A, Stambouli H, El Abida K, Bencheikh R.   +8 more
europepmc   +1 more source

Stabilization versus flexibility: Detergent‐dependent trade‐offs in neurotensin receptor 1 GPCR ensembles

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Detergents provide essential membrane‐mimetic environments for studying G protein‐coupled receptors (GPCRs), but their molecular impact on receptor energetics remains incompletely understood. We combined ligand binding, thermostability measurements, and atomistic molecular dynamics to dissect detergent‐ versus ligand‐driven stabilization in a ...
James B. Bower, Wijnand J. C. van der Velden, Karen P. Gomez, Mingzhe Pan, Fabian Bumbak, Nagarajan Vaidehi, Joshua J. Ziarek   +6 more
wiley   +1 more source

Targeting muscarinic receptors to treat schizophrenia. [PDF]

Behav Brain Res, 2021
Foster DJ, Bryant ZK, Conn PJ.
europepmc   +1 more source

Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner . [PDF]

J Pharmacol Exp Ther, 2023
Nunes EJ, Kebede N, Haight JL, Foster DJ, Lindsley CW, Conn PJ, Addy NA.   +6 more
europepmc   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Stimulation of ectopically expressed muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T cells. [PDF]

Proc Natl Acad Sci U S A, 2023
Nguyen TTT, Lu W, Zhu WS, Ansel KM, Liang HE, Weiss A.   +5 more
europepmc   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium. [PDF]

R Soc Open Sci, 2022
Claßen R, Pouokam E, Wickleder M, Diener M, Mattern A.   +4 more
europepmc   +1 more source

Striatal M₄ muscarinic receptors determine the biological rhythm of activity, with a supportive role of M₁ muscarinic receptors. [PDF]

Front Pharmacol
Janisova K, Uhlirova M, Forczek S, Myslivecek J.   +3 more
europepmc   +1 more source