Results 191 to 200 of about 2,360,825 (374)

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 15, Page 3669-3687, August 2025.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia   +14 more
wiley   +1 more source

Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders. [PDF]

open access: yesBiomedicines, 2022
Johnson CR   +4 more
europepmc   +1 more source

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano   +6 more
wiley   +1 more source

Breast cancer: Muscarinic receptors as new targets for tumor therapy. [PDF]

open access: yesWorld J Clin Oncol, 2021
Español A   +3 more
europepmc   +1 more source

Inside‐Out IP3‐Mediated G Protein‐Coupled Receptor Activation Drives Intercellular Ca2+ Signaling in the Vascular Endothelium

open access: yesThe FASEB Journal, Volume 39, Issue 14, 31 July 2025.
During endothelial cell Ca2+ wave propagation, IP3 in the initiating cell activates IP3Rs on the endoplasmic reticulum, releasing Ca2+ into the cytoplasm. We show that IP3 is required for signal propagation to neighboring cells and propose that this is due to activation of membrane‐bound pore‐dead IP3Rs, as part of a noncanonical signaling inside‐out ...
C. Buckley   +4 more
wiley   +1 more source

Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle

open access: yesJournal of Pharmacological Sciences, 2007
The inotropic response to muscarinic receptor stimulation of isolated chick ventricular myocardium was examined at various developmental stages, and the receptor subtype involved was pharmacologically characterized.
Hideaki Nouchi   +7 more
doaj  

Distribution of Presynaptlc muscarinic receptors in rat brain regions and effects of psychotropic drugs on high affinity choline uptake

open access: gold, 1979
Yukio Takano   +5 more
openalex   +1 more source

Home - About - Disclaimer - Privacy