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Muscarinic acetylcholine receptors
Shuji Uchida +3 more
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Effect of Intracavernous Simultaneous Injection of Acetylcholine and VIP on Canine Penile Erection [PDF]
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Muscarinic acetylcholine receptor
Progress in Neurobiology, 1978ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
E, Heilbronn, T, Bartfai
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Annual Review of Pharmacology and Toxicology, 1990
In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
E C, Hulme, N J, Birdsall, N J, Buckley
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In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
E C, Hulme, N J, Birdsall, N J, Buckley
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MUSCARINIC RECEPTOR DIFFERENTIATION
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Several selective antagonists are available to differentiate between muscarinic receptors.2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors.3. Reasons for differences between affinity constants determined in functional and binding studies and whether receptor subtypes ...
F, Mitchelson, L K, Choo, S, Darroch
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Muscarinic Acetylcholine Receptors
Current Pharmaceutical Design, 2006Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru, Ishii, Yoshihisa, Kurachi
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Muscarinic Receptor Trafficking
2011Knowledge of the mechanisms responsible for the trafficking of neurotransmitter receptors away from the cell surface is of obvious importance in understanding what regulates their expression and function. This chapter will focus on the mechanisms responsible for the internalization and degradation of muscarinic receptors.
Cindy, Reiner, Neil M, Nathanson
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Muscarinic Receptor Antagonists
2016Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
Maria Gabriella, Matera, Mario, Cazzola
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