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Autonomic effects of electroacupuncture in opioid‐induced constipation in male rats
Abstract The efficacy of electroacupuncture (EA) for opioid‐induced constipation (OIC) has been reported; however, the mechanism has not been sufficiently studied, and the details have not been clarified. The aims of this study were to demonstrate the delay in rat colonic transit (CT) caused by loperamide, a peripheral μ‐opioid receptor agonist, and to
Misaki Okada +3 more
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Selectivity of bethanechol on muscarinic receptors
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UEG Week 2025 Poster Presentations
United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
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Muscarinic Receptor Trafficking [PDF]
Knowledge of the mechanisms responsible for the trafficking of neurotransmitter receptors away from the cell surface is of obvious importance in understanding what regulates their expression and function. This chapter will focus on the mechanisms responsible for the internalization and degradation of muscarinic receptors.
Neil M. Nathanson, Cindy Reiner
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Annual Review of Pharmacology and Toxicology, 1990
In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
Nigel J. M. Birdsall +2 more
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In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
Nigel J. M. Birdsall +2 more
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MUSCARINIC RECEPTOR DIFFERENTIATION
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Several selective antagonists are available to differentiate between muscarinic receptors.2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors.3. Reasons for differences between affinity constants determined in functional and binding studies and whether receptor subtypes ...
S Darroch +2 more
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Muscarinic receptors in pineal
Life Sciences, 1980Abstract The presence of muscarinic receptors in sheep and rat pineals was detected by binding of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), a potent and specific muscarinic antagonist. [ 3 H]QNB binding to sheep pineal membrane resuspensions was saturable and reversible, with a rate constant for association at 37°C of 6×10 8 M −1 min −1 and a rate ...
Richard L. Taylor +2 more
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