Results 61 to 70 of about 54,030 (276)

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Mechanisms of Action Involved in the In Vivo Gastroprotective Response of Fruits: A Systematic Review

Food Frontiers, EarlyView.
ABSTRACT Gastrointestinal diseases remain a significant global health concern, primarily due to the limitations of current pharmacological treatments, which often come with adverse side effects and high recurrence rates. This situation highlights the urgent need for safer and more effective alternatives.
Isabel Sousa Alcântara, Renata Torres Pessoa, Lucas Yure Santos da Silva, Tarcisio Mendes Silva, Isis Oliveira Menezes, Anita Oliveira Brito Pereira Bezerra Martins, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley   +7 more
wiley   +1 more source

Peripheral muscarinic receptors mediate the anti-inflammatory effects of auricular acupuncture

Chinese Medicine, 2011
Background The cholinergic and opioid systems play important roles in modulating inflammation. This study tests whether auricular acupuncture (AA) produces anti-inflammatory effects via opioid and peripheral cholinergic receptors in a rat model.
Chung Wai, Zhang Hong, Zhang Shi
doaj   +1 more source

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts

Brain, Behavior, & Immunity - Health, 2020
Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning ...
Annie Bynke, Per Julin, Carl-Gerhard Gottfries, Harald Heidecke, Carmen Scheibenbogen, Jonas Bergquist   +5 more
doaj   +1 more source

Deep Vein Thrombosis Caused by Drug‐Induced Giant Bladder Diverticulum in Long‐Term Use of Antipsychotic Drugs: Case Report and Literature Review

IJU Case Reports, EarlyView.
ABSTRACT Introduction Bladder diverticulum rarely causes deep vein thrombosis (DVT) due to compression of leg veins. However, only a few cases have been reported to date. In this article, we report the first known case of DVT caused by a giant bladder diverticulum associated with long‐term use of antipsychotic medication.
Kazuki Sato, Kotaro Hirai, Yumiko Yokomizo, Azumi Fujioka, Yuki Ito, Yuichi Sugiyama, Yuko Hishiki   +6 more
wiley   +1 more source

KV7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons

Neural Plasticity, 2015
Striatal projection neurons (SPNs) process motor and cognitive information. Their activity is affected by Parkinson’s disease, in which dopamine concentration is decreased and acetylcholine concentration is increased.
M. Belén Pérez-Ramírez, Antonio Laville, Dagoberto Tapia, Mariana Duhne, Esther Lara-González, José Bargas, Elvira Galarraga   +6 more
doaj   +1 more source

Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder

Journal of Pharmacological Sciences, 2016
Muscarinic and purinergic (P2X) receptors play critical roles in bladder urothelium under physiological and pathological conditions. Aim of present study was to characterize these receptors in rat bladder urothelium and detrusor muscle using selective ...
Masaki Ogoda, Yoshihiko Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada   +4 more
doaj   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Muscarinic Receptors and Their Antagonists in COPD: Anti-Inflammatory and Antiremodeling Effects

Mediators of Inflammation, 2012
Muscarinic receptors are expressed by most cell types and mediate cellular signaling of their natural ligand acetylcholine. Thereby, they control numerous central and peripheral physiological organ responses to neuronal activity.
George Karakiulakis, Michael Roth
doaj   +1 more source