Results 1 to 10 of about 2,294,894 (319)

Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms

Nature Communications, 2022
Recent work has shown that mammalian muscle cells are comprised of multiple branching sarcomeres, though how this connectivity is regulated has remained unknown.
Peter T. Ajayi, Prasanna Katti, Yingfan Zhang, T. Bradley Willingham, Ye Sun, Christopher K. E. Bleck, Brian Glancy   +6 more
doaj   +1 more source

The importance of TP53/p53 in regulating the mitophagy-lysosomal machinery in muscle following disuse

Autophagy Reports, 2022
Since being discovered in the late 1990s, TP53/TRP53/p53 has been a focal point of research, lauded for its role as a tumor-suppressor protein. Considerable attention has also been devoted to understanding how TP53 regulates metabolic programming of the ...
Jonathan M. Memme, Ashley N. Oliveira, David A. Hood   +2 more
doaj   +1 more source

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy

Skeletal Muscle, 2023
Background Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects.
Ahmed Ismaeel, Douglas W. Van Pelt, Zachary R. Hettinger, Xu Fu, Christopher I. Richards, Timothy A. Butterfield, Jonathan J. Petrocelli, Ivan J. Vechetti, Amy L. Confides, Micah J. Drummond, Esther E. Dupont-Versteegden   +10 more
doaj   +1 more source

Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells

Physiological Reports, 2022
Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully elucidated.
Xin Rui Lim, Bernard T. Drumm, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury   +4 more
doaj   +1 more source

Mitigating N2O and NO Emissions from Direct-Seeded Rice with Nitrification Inhibitor and Urea Deep Placement

Rice Science, 2020
Soil-emitted nitrous oxide (N2O) and nitric oxide (NO) in crop production are harmful nitrogen (N) emissions that may contribute both directly and indirectly to global warming.
Yam Kanta Gaihre, Upendra Singh, Wendie D. Bible, Job Fugice, Jr., Joaquin Sanabria   +4 more
doaj   +1 more source

Prevalence of multimorbid degenerative lumbar spinal stenosis with knee or hip osteoarthritis: a systematic review and meta-analysis

BMC Musculoskeletal Disorders, 2022
Background Musculoskeletal multimorbidity is common and coexisting lumbar spinal stenosis (LSS) with knee or hip osteoarthritis (OA) has been reported. The aim of this review was to report the prevalence of multimorbid degenerative LSS with knee or hip ...
James J. Young, Rikke Krüger Jensen, Jan Hartvigsen, Ewa M. Roos, Carlo Ammendolia, Carsten Bogh Juhl   +5 more
doaj   +1 more source

Muscle versus Snail: Muscle wins [PDF]

Journal of Cell Biology, 2016
Epithelial–mesenchymal transitions (EMTs) are often governed by the transcription factor Snail and entail the loss of apical junctions from epithelial cells. In this issue, Weng and Wieschaus (2016. J Cell Biol. http://dx.doi.org/10.1083/jcb.201508056) report that actomyosin contractility can strengthen junctions to override Snail-dependent junctional ...
Simoes, Sergio, Tepass, Ulrich
openaire   +2 more sources

A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression

Skeletal Muscle, 2018
Background The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner.
Masahiro Iwata, Davis A. Englund, Yuan Wen, Cory M. Dungan, Kevin A. Murach, Ivan J. Vechetti, Christopher B. Mobley, Charlotte A. Peterson, John J. McCarthy   +8 more
doaj   +1 more source

Prevalence of multimorbid degenerative lumbar spinal stenosis with knee and/or hip osteoarthritis: protocol for a systematic review and meta-analysis

Systematic Reviews, 2020
Background Lumbar spinal stenosis (LSS) and knee and hip osteoarthritis (OA) are prevalent conditions in the aging population and published literature suggests they share many symptoms and often are present at the same time in patients.
James J. Young, Jan Hartvigsen, Rikke K. Jensen, Ewa M. Roos, Carlo Ammendolia, Carsten Bogh Juhl   +5 more
doaj   +1 more source