Results 1 to 10 of about 2,151,009 (319)

Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms

Nature Communications, 2022
Recent work has shown that mammalian muscle cells are comprised of multiple branching sarcomeres, though how this connectivity is regulated has remained unknown.
Peter T. Ajayi, Prasanna Katti, Yingfan Zhang, T. Bradley Willingham, Ye Sun, Christopher K. E. Bleck, Brian Glancy   +6 more
doaj   +1 more source

The importance of TP53/p53 in regulating the mitophagy-lysosomal machinery in muscle following disuse

Autophagy Reports, 2022
Since being discovered in the late 1990s, TP53/TRP53/p53 has been a focal point of research, lauded for its role as a tumor-suppressor protein. Considerable attention has also been devoted to understanding how TP53 regulates metabolic programming of the ...
Jonathan M. Memme, Ashley N. Oliveira, David A. Hood   +2 more
doaj   +1 more source

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Skeletal Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the ...
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer   +10 more
doaj   +1 more source

Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy

Skeletal Muscle, 2023
Background Skeletal muscle (SkM) is a large, secretory organ that produces and releases myokines that can have autocrine, paracrine, and endocrine effects.
Ahmed Ismaeel, Douglas W. Van Pelt, Zachary R. Hettinger, Xu Fu, Christopher I. Richards, Timothy A. Butterfield, Jonathan J. Petrocelli, Ivan J. Vechetti, Amy L. Confides, Micah J. Drummond, Esther E. Dupont-Versteegden   +10 more
doaj   +1 more source

Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells

Physiological Reports, 2022
Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully elucidated.
Xin Rui Lim, Bernard T. Drumm, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury   +4 more
doaj   +1 more source

Prevalence of multimorbid degenerative lumbar spinal stenosis with knee or hip osteoarthritis: a systematic review and meta-analysis

BMC Musculoskeletal Disorders, 2022
Background Musculoskeletal multimorbidity is common and coexisting lumbar spinal stenosis (LSS) with knee or hip osteoarthritis (OA) has been reported. The aim of this review was to report the prevalence of multimorbid degenerative LSS with knee or hip ...
James J. Young, Rikke Krüger Jensen, Jan Hartvigsen, Ewa M. Roos, Carlo Ammendolia, Carsten Bogh Juhl   +5 more
doaj   +1 more source

A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression

Skeletal Muscle, 2018
Background The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner.
Masahiro Iwata, Davis A. Englund, Yuan Wen, Cory M. Dungan, Kevin A. Murach, Ivan J. Vechetti, Christopher B. Mobley, Charlotte A. Peterson, John J. McCarthy   +8 more
doaj   +1 more source

HSP70 drives myoblast fusion during C2C12 myogenic differentiation

Biology Open, 2020
In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, differentiate and undergo fusion to form multinucleated myotubes. Dramatic changes in cell size, shape, metabolism and motility
Savant S. Thakur, Kristy Swiderski, Victoria L. Chhen, Janine L. James, Nicki J. Cranna, A. M. Taufiqual Islam, James G. Ryall, Gordon S. Lynch   +7 more
doaj   +1 more source

Microtubules orchestrate local translation to enable cardiac growth

Nature Communications, 2021
New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to ...
Emily A. Scarborough, Keita Uchida, Maria Vogel, Noa Erlitzki, Meghana Iyer, Sai Aung Phyo, Alexey Bogush, Izhak Kehat, Benjamin L. Prosser   +8 more
doaj   +1 more source

Prevalence of multimorbid degenerative lumbar spinal stenosis with knee and/or hip osteoarthritis: protocol for a systematic review and meta-analysis

Systematic Reviews, 2020
Background Lumbar spinal stenosis (LSS) and knee and hip osteoarthritis (OA) are prevalent conditions in the aging population and published literature suggests they share many symptoms and often are present at the same time in patients.
James J. Young, Jan Hartvigsen, Rikke K. Jensen, Ewa M. Roos, Carlo Ammendolia, Carsten Bogh Juhl   +5 more
doaj   +1 more source