Results 191 to 200 of about 462,661 (310)

Family-Wide Dysregulation of Phosphodiesterases Alters cAMP/cGMP Microdomains in Thoracic Aortic Aneurysm. [PDF]

J Cardiovasc Dev Dis
Magouliotis DE, Sicouri S, Androutsopoulou V, Baudo M, Cabrucci F, Zotos PA, Xanthopoulos A, Ramlawi B.   +7 more
europepmc   +1 more source

HMGB2–RAD21 Axis Promotes Fibro/Adipogenic Progenitor Proliferation and Regulates Fat Infiltration

Advanced Science, EarlyView.
This study constructed the first developmental atlas of embryonic skeletal muscle fibro/adipogenic progenitors (FAPs) and identified an HMGB2+ FAPs subpopulation that regulates FAP pool size and muscle homeostasis. HMGB2 directly targets the RAD21 promoter, and its knockout significantly reduces FAP numbers, thereby lowering the potential for ...
Xian Tong, Ziyun Liang, Tianqi Duo, Liping Pan, Qi Zhu, Jiete Liang, Xianyao Luo, Qingcai Feng, Rong Xu, Yihao Liu, Xu Chen, Luxi Chen, Xiaohong Liu, Yaosheng Chen, Delin Mo   +14 more
wiley   +1 more source

Extracellular Vesicles as Biological Templates for Next-Generation Drug-Coated Cardiovascular Devices: Cellular Mechanisms of Vascular Healing, Inflammation, and Restenosis. [PDF]

Cells
Dinc R, Ardic N.
europepmc   +1 more source

A Bioinstructive Injectable Hydrogel for Enhancing Intrinsic Regeneration through Cell Recruitment and Training

Advanced Science, EarlyView.
A bioinstructive injectable hydrogel enables sustained release of stromal cell–derived factor‐1 alpha (SDF‐1α) and stable retention of laminin through ionic and hydrophobic interactions. This dual‐signaling matrix promotes endogenous stem cell recruitment and training, supports angiogenesis, and enhances intrinsic regenerative processes in ischemic ...
Yurim Kim, Young‐Min Kim
wiley   +1 more source

Molecular Mechanisms Underlying Atherosclerosis and Current Advances in Targeted Therapeutics. [PDF]

Int J Mol Sci
Zhu B.
europepmc   +1 more source

AI‐Directed 3D Printing of Hierarchical Polyurethane Foams

Advanced Science, EarlyView.
Digitally guided direct ink writing, combined with AI‐generated design, enables the fabrication of hierarchical polyurethane foams with tunable multiscale porosity. This approach produces architected foams featuring interconnected open‐cell networks and tailored mechanical properties, advancing the development of adaptive, high‐performance materials ...
Dhanush Patil, Jie Tian, Kun Jiang, Clarissa Westover, Sri Vaishnavi Thummalapalli, Arunachalam Ramanathan, Arpita Shome, Natalie Crutchfield, M. Taylor Sobczak, Sean Lee, Hongyue Sun, Elizabeth J. Brisbois, Hitesh Handa, Timothy E. Long, Xianqiao Wang, Kenan Song   +15 more
wiley   +1 more source

Microbiota-Mediated Crosstalk Between the Gut and the Vascular System: Protective Effects of Novel Postbiotic Formulations on Human Endothelial and Vascular Smooth Muscle Cells. [PDF]

Int J Mol Sci
Flori L, Squarzanti DF, Lo Re M, Malfa P, Martelli A, Calderone V.   +5 more
europepmc   +1 more source

Elevator‐Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs‐Fibrin‐Mediated Macrophage Recruitment

Advanced Science, EarlyView.
This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, LingXi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang   +8 more
wiley   +1 more source

Epigenetic modifications in vascular inflammation. [PDF]

Front Immunol
Tang L, Li L, Liu Y, Zhang X, Wang X, Zheng Z, Yang P, Wu H.   +7 more
europepmc   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source