Results 1 to 10 of about 242,639 (216)

Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins

Journal of Extracellular Vesicles, 2020
The vascular endothelium and smooth muscle form adjacent cellular layers that comprise part of the vascular wall. Each cell type can regulate the other’s structure and function through a variety of paracrine effectors.
Michael J. Boyer, Yayoi Kimura, Tomoko Akiyama, Ariele Y. Baggett, Kyle J. Preston, Rosario Scalia, Satoru Eguchi, Victor Rizzo   +7 more
doaj   +2 more sources

Vascular smooth muscle cell senescence in atherosclerosis [PDF]

Cardiovascular Research, 2006
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo.
Mary M Kavurma, Martin R Bennett, Scott Stephen   +2 more
exaly   +3 more sources

Mechanisms of Vascular Smooth Muscle Cell Migration [PDF]

Circulation Research, 2007
Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. Many proximal signals and signal transduction pathways activated during migration have been identified, as well as components of the cellular machinery that affect cell movement.
William T Gerthoffer
exaly   +3 more sources

Survivin modulates stiffness-induced vascular smooth muscle cell motility [PDF]

APL Bioengineering
Arterial stiffness is a contributor to cardiovascular diseases (CVDs) and is associated with the aberrant migration of vascular smooth muscle cells (VSMCs). However, the mechanisms driving VSMC migration in stiff environments remain unclear.
Thomas Mousso, Kalina Rice, Bat-Ider Tumenbayar, Khanh Pham, Yuna Heo, Su Chin Heo, Kwonmoo Lee, Andrew T. Lombardo, Yongho Bae   +8 more
doaj   +2 more sources

EPAC in Vascular Smooth Muscle Cells [PDF]

International Journal of Molecular Sciences, 2020
Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Nadine Wehbe, Suzanne Awni Nasser, Yusra Al-Dhaheri, Rabah Iratni, Alessandra Bitto, Ahmed F. El-Yazbi, Adnan Badran, Firas Kobeissy, Elias Baydoun, Ali H. Eid   +9 more
openaire   +3 more sources

Role of smooth muscle progenitor cells in vascular mechanical injury and repair

Medicine in Novel Technology and Devices, 2022
Smooth muscle progenitor cells are precursor cells that express both smooth muscle cell and stem cell markers, and can differentiate into smooth muscle cells under specific condition.
Zhu-feng Dong, Yan Long, Wen-jie Sun, Yang Wang, Yu-hua Huang, Gui-xue Wang, Bin He, Tie-ying Yin   +7 more
doaj   +1 more source

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]

PLoS ONE, 2015
Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz, Tamara C Murphy, Anastassia P Pokutta-Paskaleva, Rudolph L Gleason, Alicia N Lyle, W Robert Taylor, Mitsi A Blount, Juan Cheng, Qinglin Yang, Roy L Sutliff, C Michael Hart   +10 more
doaj   +1 more source

Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro

Frontiers in Physiology, 2022
Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic, Fatima Daoud, Fatima Daoud, Neserin Ali, Katarzyna Kawka, Johan Holmberg, Sebastian Albinsson   +6 more
doaj   +1 more source

Smoothelin in Vascular Smooth Muscle Cells [PDF]

Trends in Cardiovascular Medicine, 2007
Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for ...
van Eys, G.J.J.M., Niessen, P.M.G., Rensen, S.S.M.   +2 more
openaire   +3 more sources

Smooth muscle cells and vascular diseases [PDF]

Cardiovascular Research, 2012
Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, and, due to their myosin/actin interactions, they are also responsible for arterial contractile tonus and regulating blood pressure and flow in relation to specific metabolic demands.
Jean-Baptiste, Michel, Zhenlin, Li, Patrick, Lacolley   +2 more
openaire   +2 more sources