Results 11 to 20 of about 242,639 (216)
Vascular smooth muscle cells in atherosclerosis [PDF]
Nature Reviews Cardiology, 2019 Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and ...
Basatemur, Gemma L +4 more
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Vascular smooth muscle cell dysfunction in neurodegeneration
Frontiers in Neuroscience, 2022 Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is ...
Genevieve Hayes +7 more
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Vascular Smooth Muscle Cells in Atherosclerosis [PDF]
Circulation Research, 2016 The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced plaques are entirely beneficial, for example preventing rupture of the fibrous cap.
Martin R, Bennett +2 more
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Redox Biology, 2022 Prevention of phenotype switching of vascular smooth muscle cells is an important determinant of normal vascular physiology. Hydrogen peroxide (H2O2) promotes osteogenic differentiation of vascular smooth muscle cells through expression of Runt related ...
Kai er Ying +7 more
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Smooth Muscle Cells for Vascular Engineering [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2011 In the first decade of this century, ever-increasing scientific and technological advances are revolutionizing our approaches to developing therapies that bring about the promise of personalized medicine and the possibility of regenerative interventions.
Y Eugene, Chen +2 more
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Heliyon, 2023 Vascular smooth muscle cells (VSMCs) are primarily responsible for vasoconstriction and the regulation of blood pressure1. Pyroptosis, a particular form of regulated cell death, is involved in multiple vascular injuries, including hypertensive vascular ...
Zimin Fang +9 more
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Metabolism of vascular smooth muscle cells in vascular diseases [PDF]
American Journal of Physiology-Heart and Circulatory Physiology, 2020 Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer of arteries and are essential for arterial physiology and pathology. It is becoming increasingly clear that VSMCs can alter their metabolism to fulfill the bioenergetic and biosynthetic requirements. During vascular injury, VSMCs switch from a quiescent “contractile”
Jia, Shi +4 more
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The role of p53 in the alternation of vascular functions
Frontiers in Pharmacology, 2022 Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system.
Gabriel Hoi-Huen Chan +7 more
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TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms
JACC: Basic to Translational Science, 2023 Summary: Phenotypic switching of vascular smooth muscle cells is a central process in abdominal aortic aneurysm (AAA) pathology. We found that knockdown TCF7L1 (transcription factor 7-like 1), a member of the TCF/LEF (T cell factor/lymphoid enhancer ...
Jing Wang, MM +7 more
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Vascular Smooth Muscle Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016 Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully differentiated phenotype conferred by the transcriptional activity of myocardin and serum response ...
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