Results 181 to 190 of about 1,110,204 (301)

Deubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization. [PDF]

J Cachexia Sarcopenia Muscle
Chae J, Woo SM, Seo SU, Yook S, Cho HJ, Lee JY, Min KJ, Park J, Ryu D, Kwon TK.   +9 more
europepmc   +1 more source

Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury. [PDF]

Function (Oxf)
Keeble AR, Owen AM, Gonzalez-Velez S, Thomas NT, Brightwell CR, Balawender PJ, O'Daniel MG, Weiss HC, Noehren H, Thompson H, Zuluaga-Osorio KS, Bates ZT, Gottlieb L, Long DE, Harrison DA, Kern PA, Conley CE, Samaan MA, Duncan ST, Stone AV, Johnson DL, Wen Y, Noehren B, Dungan CM, Fry CS.   +24 more
europepmc   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Effect of muscle atrophy on fracture healing: insights from a tibial musculoskeletal-finite element model. [PDF]

Biomech Model Mechanobiol
Ding Q, Li L, Zhang L.
europepmc   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Selective Small-Molecule AdipoR1 Agonist 3-Hydroxy Pterocarpan Salt (CDRI-1709S) Ameliorates Skeletal Muscle Atrophy. [PDF]

J Cachexia Sarcopenia Muscle
Moin MR, Pal S, Das S, Awasthi P, Talukdar A, Kumar A, Varode SS, Nikolas N, Khatoon S, Mugale MN, Guha R, Sanyal S, Goel A.   +12 more
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

A Novel Small-Molecule Dual Adiponectin Receptor 1/2 Agonist Induces Myogenesis and Ameliorates Skeletal Muscle Atrophy. [PDF]

J Cachexia Sarcopenia Muscle
Das S, Awasthi P, Moin MR, Pal S, Talukdar A, Kumar A, Nikolas N, Varode SS, Khatoon S, Das N, Chattopadhyay S, Mugale MN, Guha R, Sanyal S, Goel A.   +14 more
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Mitophagy in Botulinum Toxin Type A-Induced Muscle Atrophy. [PDF]

Oral Dis
Mao QY, Chen Z, Xie S, Xiang RL, Cai ZG.
europepmc   +1 more source