Results 191 to 200 of about 1,166,632 (295)

Dietary Resistant Maltodextrin Attenuates Skeletal Muscle Atrophy in Association with Modulation of the Microbiota-Gut-Muscle Axis in Aged Mice. [PDF]

J Microbiol Biotechnol
Nam Y, Hwang H, Lim D, Cho E, Kim K, Sa S, Han JS, Kim W.   +7 more
europepmc   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Vitamin D Ameliorates Skeletal Muscle Atrophy After Spinal Cord Injury by Upregulating TIGAR and Enhancing Mitochondrial Function. [PDF]

J Cachexia Sarcopenia Muscle
Dong Z, Li N, Guo Y, Sun H, Shi W, Zhou M, Tong X, Wang Z, Qian F, Guo Y.   +9 more
europepmc   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source

Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice. [PDF]

Nat Commun
Burke BI, Valentino TR, Ismaeel A, El-Amouri SS, Goh J, Scott LN, Walton BJ, Joshi JK, Wood CR, Burrows-Franco A, May JB, Johnson LA, Flythe MD, Wen Y, McCarthy JJ.   +14 more
europepmc   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Deubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization. [PDF]

J Cachexia Sarcopenia Muscle
Chae J, Woo SM, Seo SU, Yook S, Cho HJ, Lee JY, Min KJ, Park J, Ryu D, Kwon TK.   +9 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury. [PDF]

Function (Oxf)
Keeble AR, Owen AM, Gonzalez-Velez S, Thomas NT, Brightwell CR, Balawender PJ, O'Daniel MG, Weiss HC, Noehren H, Thompson H, Zuluaga-Osorio KS, Bates ZT, Gottlieb L, Long DE, Harrison DA, Kern PA, Conley CE, Samaan MA, Duncan ST, Stone AV, Johnson DL, Wen Y, Noehren B, Dungan CM, Fry CS.   +24 more
europepmc   +1 more source