Results 11 to 20 of about 920,865 (221)

Simple Methods for Permanent or Transient Denervation in Mouse Sciatic Nerve Injury Models

Bio-Protocol, 2022
Our ability to move and breathe requires an efficient communication between nerve and muscle that mainly takes place at the neuromuscular junctions (NMJs), a highly specialized synapse that links the axon of a motor neuron to a muscle fiber. When NMJs or
Alexis Osseni, Jean- Thomas, Alireza Ghasemizadeh, Laurent Schaeffer, Vincent Gache   +4 more
doaj   +2 more sources

Absence of physiological Ca2+ transients is an initial trigger for mitochondrial dysfunction in skeletal muscle following denervation [PDF]

Skeletal Muscle, 2017
Background Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction.
Chehade Karam, Jianxun Yi, Yajuan Xiao, Kamal Dhakal, Lin Zhang, Xuejun Li, Carlo Manno, Jiejia Xu, Kaitao Li, Heping Cheng, Jianjie Ma, Jingsong Zhou   +11 more
doaj   +2 more sources

The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice. [PDF]

PLoS ONE, 2012
Skeletal muscle atrophy is a consequence of muscle inactivity resulting from denervation, unloading and immobility. It accompanies many chronic disease states and also occurs as a pathophysiologic consequence of normal aging.
Preena Nagpal, Pamela J Plant, Judy Correa, Alexandra Bain, Michiko Takeda, Hiroshi Kawabe, Daniela Rotin, James R Bain, Jane A E Batt   +8 more
doaj   +3 more sources

Muscle fibre denervation in ageing

Clinical Science
Abstract Muscle fibre denervation describes the loss of effective neural input from a motor neuron to one or more muscle fibres. In ageing, denervation is increasingly recognised as an important contributor to progressive declines in muscle strength and functional capacity, yet it remains heterogeneous and difficult to define in ...
Soendenbroe, Casper
openaire   +5 more sources

Low‐Carbohydrate Diet Exacerbates Denervation‐Induced Atrophy of Rat Skeletal Muscle Under the Condition of Identical Protein Intake

Journal of Cachexia, Sarcopenia and Muscle
Background While decreased protein intake is associated with muscle mass loss, it is unclear whether a decrease in carbohydrate intake adversely affects muscle atrophy independently of protein intake.
Aki Yokogawa, Kohei Kido, Ikuru Miura, Eisuke Oyama, Daisuke Takakura, Keigo Tanaka, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Kentaro Kawanaka   +9 more
doaj   +2 more sources

Time-Dependent Changes in Muscle IGF1-IGFBP5-PAPP System after Sciatic Denervation [PDF]

, 2023
Denervation-induced muscle atrophy is a frequent cause of skeletal muscle diseases. However, the role of the most important muscle growth factor, insulin-like growth factor (IGF-1), in this process is poorly understood.
Jaque García, Daniel, Asunción López-Calderón, López-Calderón, Asunción, Nieto Bona, M Paz, Teresa Priego, Martín, Ana Isabel, Elena Nebot, Nieto-Bona, M. Paz, Miriam Granado, Martín Velasco, Ana Isabel, Álvaro Moreno-Rupérez, Daniel Jaque, Priego, Teresa, Ana Isabel Martín, Nieto Bona, María Paz, Moreno Rupérez, Álvaro, M. Paz Nieto-Bona, Nebot, Elena, Granado García, Miriam, Nebot Valenzuela, Elena, Moreno-Rupérez, Álvaro, Priego Cuadra, Teresa, Granado, Miriam, López-Calderón Barreda, Asunción, Jaque, Daniel   +24 more
core   +1 more source

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]

, 2013
BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph, Bentzinger, C. Florian, Guridi, Maitea, Castets, Perrine, Hall, Michael N, Tintignac, Lionel A., Hall, Michael N., Perrine Castets, Romanino, Klaas, Tintignac, Lionel, Rüegg, Markus A, Michael N Hall, Lin, Shuo, Markus A Rüegg, Bentzinger, C Florian, Christoph Handschin, Serge Summermatter, Summermatter, Serge, C Bentzinger, Klaas Romanino, Maitea Guridi, Shuo Lin, Rüegg, Markus A., Lionel A Tintignac, Lin S, Castets P, Rüegg MA, Bentzinger CF, Tintignac, Lionel A, Guridi M, Tintignac LA, Summermatter S, Hall MN, Romanino K, Handschin C   +34 more
core   +1 more source

Skeletal Muscle Denervation: Past, Present and Future

, 2022
This Special Issue presents some of the most recent studies on the skeletal muscle denervation [...
Kostrominova, Tatiana Y., Tatiana Y. Kostrominova   +1 more
core   +1 more source

Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle [PDF]

, 2021
Denervation rapidly induces insulin resistance (i.e., impairments in insulin-stimulated glucose uptake and signaling proteins) in skeletal muscle. Surprisingly, whether this metabolic derangement is long-lasting is presently not clear.
Carol A. Witczak, McMillin, Shawna L., Brault, Jeffrey J., Shawna L. McMillin, Jeffrey J. Brault, Barbara B. Kahn, Witczak, Carol A., Erin C. Stanley, Kahn, Barbara B., Stanley, Erin C., Luke A. Weyrauch, Weyrauch, Luke A.   +11 more
core   +1 more source

Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality. [PDF]

, 2016
It is well known that the ubiquitin-proteasome system is activated in response to skeletal muscle wasting and functions to degrade contractile proteins. The loss of these proteins inevitably reduces skeletal muscle size (i.e., quantity).
LaDora V. Thompson (2295052), Haiming M Liu, Haiming M. Liu (2937996), Cory W. Baumann (2937993), Liu, Haiming M., LaDora V Thompson, Thompson, LaDora V., Baumann, Cory W., Cory W Baumann   +8 more
core   +2 more sources