Results 21 to 30 of about 920,865 (221)

Myogenin regulates denervation‐dependent muscle atrophy in mouse soleus muscle [PDF]

, 2011
Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy‐related genes, like Atrogin‐1 and MuRF‐1, are intimately ...
Macpherson, Peter C. D., Xun Wang, Peter C. D. Macpherson, Wang, Xun, Goldman, Daniel J., Daniel Goldman   +5 more
core   +1 more source

Lactate administration does not affect denervation‐induced loss of mitochondrial content and muscle mass in mice

FEBS Open Bio, 2021
Lactate is considered to be a signaling molecule that induces mitochondrial adaptation and muscle hypertrophy. The purpose of this study was to examine whether lactate administration attenuates denervation‐induced loss of mitochondrial content and muscle
Kenya Takahashi, Yu Kitaoka, Yutaka Matsunaga, Hideo Hatta   +3 more
doaj   +1 more source

TREATMENT OF DENERVATED MUSCLE [PDF]

Journal of the American Medical Association, 1920
In 1841, Reid 1 advanced the theory that the atrophy of denervated muscle was caused by inactivity. He found that in the frog, a denervated muscle that was exercised daily by galvanic stimulation did not lose weight. Untreated muscles were thought to decrease one half, but it is now known that frog's muscle does not atrophy nearly so rapidly as Reid ...
openaire   +2 more sources

Increasing autophagy does not affect neurogenic muscle atrophy

European Journal of Translational Myology, 2018
Physiological autophagy plays a crucial role in the regulation of muscle mass and metabolism, while the excessive induction or the inhibition of the autophagic flux contributes to the progression of several diseases.
Eva Pigna, Krizia Sanna, Dario Coletti, Zhenlin Li, Ara Parlakian, Sergio Adamo, Viviana Moresi   +6 more
doaj   +1 more source

m6A demethylase ALKBH5 drives denervation‐induced muscle atrophy by targeting HDAC4 to activate FoxO3 signalling

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Skeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment of primary neuropathies, it is a clinical condition that should be investigated.
Yuantong Liu, Tianjian Zhou, Qinghe Wang, Runhan Fu, Zengfu Zhang, Nandi Chen, Zhizhong Li, Guoyong Gao, Songlin Peng, Dazhi Yang   +9 more
doaj   +1 more source

Decoding the transcriptome of denervated muscle at single‐nucleus resolution

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Skeletal muscle exhibits remarkable plasticity under both physiological and pathological conditions. One major manifestation of this plasticity is muscle atrophy that is an adaptive response to catabolic stimuli.
Hongchun Lin, Xinxin Ma, Yuxiang Sun, Hui Peng, Yanlin Wang, Sandhya Sara Thomas, Zhaoyong Hu   +6 more
doaj   +1 more source

Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures [PDF]

, 2012
Denervation-induced changes in excitatory synaptic strength were studied following entorhinal deafferentation of hippocampal granule cells in mature (≥3 weeks old) mouse organotypic entorhino-hippocampal slice cultures.
Roeper, Jochen, Roeper Jochen, Winkels, Raphael, Denise Becker (179935), Thomas Deller, Thomas Deller (179947), Denise Becker, Jedlička, Peter, Becker Denise, Jochen Roeper, Jedlicka Peter, Winkels Raphael, Andreas Vlachos (47497), Vlachos Andreas, Vlachos, Andreas, Andreas Vlachos, Peter Jedlicka, Jochen Roeper (179944), Becker, Denise, Peter Jedlicka (179938), Raphael Winkels (179941), Deller Thomas, Deller, Thomas, Raphael Winkels   +23 more
core   +1 more source

Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy

Radiology Case Reports, 2017
Denervation of muscle usually leads to muscle atrophy with fatty replacement but, uncommonly, also results in muscle hypertrophy or pseudohypertrophy with fatty replacement.
Kin Hoi Wong, MBBS, FRCR, Maria Bernadette Che Ying Chow, MBChB, Tun Hing Lui, MBBS, FRCSEd, FHKCOS, FHKAM(Orthopaedic Surgery), Yue Kew Cheong, MBBS, BSc, MRCP, FRCPath, FHKCPath, FHKAM(Pathology), Kwok Fai Tam, MBChB, FRCR, FHKCR, FHKAM(Radiology)   +4 more
doaj   +1 more source

Blocking skeletal muscle DHPRs/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1). [PDF]

PLoS Genetics, 2019
Schwann cells are integral components of vertebrate neuromuscular synapses; in their absence, pre-synaptic nerve terminals withdraw from post-synaptic muscles, leading to muscle denervation and synapse loss at the developing neuromuscular junction (NMJ).
Yun Liu, Yoshie Sugiura, Fujun Chen, Kuo-Fen Lee, Qiaohong Ye, Weichun Lin   +5 more
doaj   +1 more source

Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle-Atrophy-Associated Ubiquitin Ligase Cbl-b

International Journal of Endocrinology, 2013
Background. Unloading stress induces skeletal muscle atrophy. We have reported that Cbl-b ubiquitin ligase is a master regulator of unloading-associated muscle atrophy.
Tomoki Abe, Shohei Kohno, Tomonari Yama, Arisa Ochi, Takuro Suto, Katsuya Hirasaka, Ayako Ohno, Shigetada Teshima-Kondo, Yuushi Okumura, Motoko Oarada, Inho Choi, Rie Mukai, Junji Terao, Takeshi Nikawa   +13 more
doaj   +1 more source