Results 41 to 50 of about 920,865 (221)
An evaluation of common markers of muscle denervation in denervated young-adult and old rat gastrocnemius muscle. [PDF]
, 2018 A large part of age-related muscle wasting is due to incomplete reinnervation of fibres that have become denervated following motoneuron loss. Neural cell adhesion molecule (NCAM) and sodium channel NaV1.5 are considered markers for denervation, but the ...
Galinska, M +7 more
core +2 more sources
Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging
Cells, 2020 Skeletal muscle deteriorates with aging, contributing to physical frailty, poor health outcomes, and increased risk of mortality. Denervation is a major driver of changes in aging muscle.
Maria-Eleni Anagnostou +1 more
doaj +1 more source
Denervation in hemiplegic muscles. [PDF]
Stroke, 1990 This study examined the frequency of denervation activity in hemiplegic muscles in relation to the size and location of the central lesion. We studied 20 patients, 14 with major unilateral cerebral infarctions in the middle cerebral or internal carotid territories; four with a single lacune in the pons, internal capsule, or thalamus; and two with ...
W F, Brown, R, Snow
openaire +2 more sources
A study of the reinnervation of stretch receptors in cat muscle following nerve injury [PDF]
, 1983 An histological investigation into the reinnervation of stretch receptors necessarily requires a reliable staining technique. To achieve this, silver staining has been investigated and standardised.
Boddy, Alan
core
Advanced Science, EarlyView.Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma +12 more
wiley +1 more source
NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy
Cells, 2020 Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities.
Sara Marmolejo-Martínez-Artesero +4 more
doaj +1 more source
Dicer-mediated miRNA processing is not involved in controlling muscle mass during muscle atrophy
Scientific Reports, 2021 Muscle atrophy occurs in a variety of physiological and pathological conditions. Specific molecular networks that govern protein synthesis and degradation play important roles in controlling muscle mass under diverse catabolic states.
Satoshi Oikawa +3 more
doaj +1 more source
Advanced Science, EarlyView.This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun +12 more
wiley +1 more source
Effects of skeletal muscle denervation on potency of rocuronium
, 2011 Background: Rocuronium is an alternative to succinylcholine for rapid tracheal intubation after major thermal injury and other forms of critical illness that cause denervation changes in skeletal muscle.
Wang Hong +6 more
core +1 more source
Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]
, 1997 The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Arber, S. +8 more
core +1 more source