Results 51 to 60 of about 920,865 (221)

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle.

PLoS ONE, 2012
Although denervation has long been implicated in aging muscle, the degree to which it is causes the fiber atrophy seen in aging muscle is unknown. To address this question, we quantified motoneuron soma counts in the lumbar spinal cord using choline ...
Sharon L Rowan, Karolina Rygiel, Fennigje M Purves-Smith, Nathan M Solbak, Douglas M Turnbull, Russell T Hepple   +5 more
doaj   +1 more source

Mechanical Distraction Engages a Neuro‐Immune Program to Drive Regenerative Soft‐Tissue Healing in Ilizarov Bone Transport

Advanced Science, EarlyView.
Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu, Jiayu Chen, Xuehuan Wen, Kaijia Tang, Ling Gao, Chenxing Wang, Yixuan Feng, Si‐He Qin, Tao Chen, Xiaohua Yu   +9 more
wiley   +1 more source

Effect of denervation and cocainization on activity of creatine synthesizing enzyme and phosphorylase in skeletal muscle

, 1959
Creatine synthesizing enzyme and phosphorylase were determined in the gastrocnemius of the rat, and effects of epinephrine, norepinephrine, cocaine and denervation on them were studied.
Takashi Matsui, Kaname Kuriaki
core   +1 more source

mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 [PDF]

, 2019
Loss of innervation of skeletal muscle is a determinant event in several muscle diseases. Although several effectors have been identified, the pathways controlling the integrated muscle response to denervation remain largely unknown. Here, we demonstrate
Cruz, Joseph, Guridi, Maitea, Castets, Perrine, Wild, Franziska, Ibebunjo, Chikwendu, Glass, David J., Falcetta, Denis, Rion, Nathalie, Lin, Shuo, Reischl, Markus, Eickhorst, Christopher, Sinnreich, Michael, Rudolf, Rüdiger, Brockhoff, Marielle, Théodore, Marine, Rüegg, Markus A., Guérard, Laurent, Théodore M, Lin S, Castets P, Cruz J, Rion N, Rüegg MA, Ibebunjo C, Rudolf R, Guridi M, Eickhorst C, Reischl M, Glass DJ, Guérard L, Falcetta D, Brockhoff M, Sinnreich M, Wild F   +33 more
core   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

The effects of denervation and formoterol administration on facial growth

Australasian Orthodontic Journal, 2014
Objective: To identify and demonstrate possible alterations of skeletal structures which might follow either unilateral surgical denervation of the masseter muscle, unilateral intramuscular injection of formoterol directly into the masseter muscle, or ...
Fitzpatrick Brendan, Woods Michael, Lynch Gordon, Manton David   +3 more
doaj   +1 more source

Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. [PDF]

PLoS ONE, 2016
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome.
Haiming M Liu, Deborah A Ferrington, Cory W Baumann, LaDora V Thompson   +3 more
doaj   +1 more source

Effects of denervation on normal and dystrophic muscle: DNA and nucleotide enzymes

, 1965
The activities of five enzymes associated with nucleotide metabolism, as well as values for protein and DNA-P, in homogenates from normal, dystrophic, and denervated (3–46 days) normal and dystrophic mouse gastrocnemii have been reported.
M. W. McCaman, R. E. McCaman
core   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source