Results 51 to 60 of about 1,170,413 (268)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway

Cells, 2019
Leptin is an important secretory protein that regulates the body’s intake and energy consumption, and the functions of the Hh signaling pathway related to white adipocyte browning are controversial. It has been reported that leptin plays a critical
Jie Wang, Jing Ge, Haigang Cao, Xiaoyu Zhang, Yuan Guo, Xiao Li, Bo Xia, Gongshe Yang, Xin’e Shi   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Teff (Eragrostis tef) dry matter yield, nutrient uptake partitioning, and nitrogen use efficiency indices affected by nitrogen rate under balanced fertilization

Sustainable Environment
Teff [Eragrostis tef (Zucc.) Trotter] has gained high demand and popularity across the world in recent years. Data on nutrient uptake and partitioning and nitrogen use efficiency (NUE) indices of teff under balanced fertilization are scarce. A greenhouse
Mulugeta Demiss, Upendra Singh, Job Fugice, Zachary P. Stewart, Latha Nagarajan   +4 more
doaj   +1 more source

Effects of Manganese Nanoparticle Exposure on Nutrient Acquisition in Wheat (Triticum aestivum L.)

Agronomy, 2018
Nanoparticles are used in a variety of products, including fertilizer-nutrients and agro-pesticides. However, due to heightened reactivity of nano-scale materials, the effects of nanoparticle nutrients on crops can be more dramatic when compared to non ...
Christian O. Dimkpa, Upendra Singh, Ishaq O. Adisa, Prem S. Bindraban, Wade H. Elmer, Jorge L. Gardea-Torresdey, Jason C. White   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Teff Yield and Nutrient Uptake Partitioning During Prolonged Waterlogging: A Preliminary Greenhouse Study

Plant-Environment Interactions
There is a lack of studies examining the effects of prolonged waterlogging on both yield and nutrient uptake partitioning in teff. A greenhouse study was conducted to assess the impact of different durations of waterlogging on teff's growth, yield ...
Mulugeta Demiss, Upendra Singh, Job Fugice, Zachary P. Stewart, Latha Nagarajan   +4 more
doaj   +1 more source

The molecular dysregulation of excitation contraction coupling in patients with congenital muscle disorders [PDF]

, 2015
Excitation contraction coupling (ECC) is the process whereby an action potential spreading throughout the muscle membrane activates muscle contraction, by releasing Ca2+ from the Sarcoplasmic Reticulum (SR).
Rokach, Ori
core   +1 more source