Results 61 to 70 of about 1,170,413 (268)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Nutritional intervention during gestation alters growth, body composition and gene expression patterns in skeletal muscle of pig offspring

, 2011
peer-reviewedVariations in maternal nutrition during gestation can influence foetal growth, foetal development and permanently ‘programme’ offspring for postnatal life.
Markham, T., L. Giblin, Stickland, N C, O'Reilly, J J, O'Reilly, James J, Stickland, N. C., T. Markham, Lawlor, P G, P.G. Lawlor, J.P. Kerry, Lawlor, Peadar G, Lynch, P Brendan, Lynch, P B, Markham, T C W, Teagasc Anim & Grassland Res, P.B. Lynch, Kerry, J P, Teagasc Food Res Centre, N.C. Stickland, D.P. Berry, University College Cork, Mc Namara, Louise, L.B. McNamara, Kerry, Joseph P., Giblin, Linda, McNamara, L B, J.J. O'Reilly, Giblin, L, Berry, D P, Berry, Donagh   +29 more
core   +1 more source

A conditional mouse model for the characterization of mTORC1 function in muscle and brain [PDF]

, 2010
The Ser/Thr kinase mammalian target of rapamycin (mTOR) regulates cell growth in response to extracellular stimulation with growth factors and to intracellular factors that sense the nutritional and the energy state of the cell.
Cloëtta, Dimitri Yves Reto
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

PGC-1α modulates skeletal muscle regeneration by affecting immune response and satellite cell behavior [PDF]

, 2014
The benefits of exercise on wellbeing have been known to mankind for thousands of years, yet the underlying mechanisms of exercise have been explained only relatively recently.
Dinulović, Ivana
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Integrating parental genomes to reduce reference bias and identify intramuscular fat genes in Qinchuan Black pigs

Journal of Animal Science and Biotechnology
Background Traditional genomic analysis relies on a single reference genome, which struggles to effectively characterize the genetic diversity among populations. This is due to the substantial genetic differences between the genome of the studied species
Guangquan Lv, Peiyu Yang, Ao Guo, Minghao Cao, Dong Li, Zhe Liu, Mingyu Wang, Jingchun Sun, Rongrong Ding, Taiyong Yu   +9 more
doaj   +1 more source

Research Note: Association of temporal expression of myostatin with hypertrophic muscle growth in different Japanese quail lines

Poultry Science, 2020
Myostatin (MSTN) negatively regulates in muscle growth and development. Among alternative splicing isoforms of avian MSTN, MSTN-A has antimyogenic activities and MSTN-B functions as a promyogenic factor.
Dong-Hwan Kim, Young Min Choi, Yeunsu Suh, Sangsu Shin, Joonbum Lee, Seongsoo Hwang, Kichoon Lee   +6 more
doaj   +1 more source

Changes of smooth muscle contractile filaments in small bowel atresia

, 2012
AIM: To investigate morphological changes of intestinal smooth muscle contractile fibres in small bowel atresia patients. METHODS: Resected small bowel specimens from small bowel atresia patients (n = 12) were divided into three sections (proximal ...
Rolle, Udo, Metzger, Roman, Fiegel, Henning C., Gfrörer, Stefan, Ramachandran, Priya   +4 more
core   +1 more source