Results 71 to 80 of about 1,170,413 (268)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Integrated multi-omics analysis reveals component differences and their regulatory mechanisms of adipose tissue as lard raw material between Bamei and Large White pigs

Food Science and Human Wellness
Bamei pigs, an indigenous Chinese breed, yield meat with a delectable flavor and boast higher carcass fat content compared to commercial breeds, making them a rich food source for humans.
Rui Li, Haozhe Han, Zihang Tie, Ran Wu, Mengmeng Bai, Mingyu Wang, Gongshe Yang, Weijun Pang, Rui Cai   +8 more
doaj   +1 more source

Does acute passive stretching increase muscle length in children with cerebral palsy? [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund. Copyright @ The Authors. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use ...
Theis, Nicola, Amir A. Mohagheghi, Mohagheghi, AA, Korff, Thomas, Thomas Korff, Nicola Theis, Korff, T, Kairon, H, Mohagheghi, Amir A., Mohagheghi, Amir A, Harvey Kairon, Kairon, Harvey, Theis, N   +12 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The hybridization analysis of pedigree: whole-genome re-sequencing reveals genomics characterization and genetic basis of growth trait of Qinchuan black pigs

BMC Genomics
Background Understanding the genetic basis of hybridization trait between Chinese indigenous pig and their commercial relatives may contribute to germplasm innovation. The Qinchuan black (QCB) pig is a new composite breed under development generated from
Minghao Cao, Tiantian Yuan, Dong Li, Xiang Li, Yanyan Huang, Jingchun Sun, Yulong Wang, Taiyong Yu   +7 more
doaj   +1 more source

Development of the stapedius muscle and pyramidal eminence in humans

, 2009
The aim of the study was to systematize the key developmental phases of the stapedius muscle and the pyramidal eminence to clarify their formation, as well as to understand the variations and anomalies that can affect these structures.
Rodríguez Vázquez, José Francisco
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Whole genome and transcriptome analyses identify genetic markers associated with growth traits in Qinchuan black pig

BMC Genomics
Background Growth traits are economically important traits in pig breeding. However, the genetic mechanism of growth traits is still unclear. Qinchuan Black (QCB) pigs are crossbred and produced by hybridizing Guanzhong Black (GZB) pigs and Large White ...
Yaxin Wang, Guangquan Lv, Zhe Liu, Ye Cheng, Rongrong Ding, Gongshe Yang, Taiyong Yu   +6 more
doaj   +1 more source

New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases [PDF]

, 2013
Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases ...
Handschin, Christoph, Pérez-Schindler, Joaquín   +1 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source