Results 71 to 80 of about 19,233,520 (354)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Digital mapping of Ghana’s soil properties and nutrients: performance of spline and weighted average approaches

Geoderma
Soil fertility is a critical factor in sustaining crop productivity and meeting the food demands of the world’s growing population. Assessing the fertility status of soil allows for the adoption of targeted agricultural practices to enhance crop yields ...
Kora B.D. Simperegui, Anselme K.K. Kouame, Benjamin Kwesie, Prem S. Bindraban, William Adzawla, Eric Asamoah, Mohamed El Gharous   +6 more
doaj   +1 more source

A Modified Pre-plating Method for High-Yield and High-Purity Muscle Stem Cell Isolation From Human/Mouse Skeletal Muscle Tissues

Frontiers in Cell and Developmental Biology, 2020
Primary culture of skeletal muscle stem cells (MuSCs) is indispensable to study the dynamics of muscle regeneration and homeostasis. Here we describe the modified pre-plating method for isolating MuSCs in culture with greatly improved purity, yield, and ...
Kiyoshi Yoshioka, Yasuo Kitajima, Narihiro Okazaki, Ko Chiba, Akihiko Yonekura, Yusuke Ono   +5 more
doaj   +1 more source

Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]

, 2019
Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John, Tetsuake, Miyake, Tripathi, Soma   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Specific muscle targeted delivery of miR-130a loaded lipid nanoparticles: a novel approach to inhibit lipid accumulation in skeletal muscle and obesity

Journal of Nanobiotechnology
Background Skeletal muscle lipid deposition is a key manifestation of obesity, often accompanied by decreased exercise capacity and muscle atrophy. Skeletal muscle as the largest organ in the body, makes it challenges for designing targeted drug delivery
Yingqian Wang, Zeqiang Ma, Lehua Jiang, Nataraj Bojan, Yiwen Sha, Boyu Huang, Lianxi Ming, Junnan Shen, Weijun Pang   +8 more
doaj   +1 more source

Research Note: Increased myostatin expression and decreased expression of myogenic regulatory factors in embryonic ages in a quail line with muscle hypoplasia

Poultry Science, 2021
Genetic selection of quail for a low body weight for more than 80 generations established a low-weight (LW) Japanese quail line that has been previously characterized to have a muscle hypoplasia phenotype.
Dong-Hwan Kim, Young Min Choi, Yeunsu Suh, Sangsu Shin, Joonbum Lee, Seongsoo Hwang, Sang Suk Lee, Kichoon Lee   +7 more
doaj   +1 more source

Intelligent modelling and control with fatigue reduction for fes induced knee joint of hemiplegic for rehabilitation [PDF]

, 2017
Functional electrical stimulation (FES) is one of the treatment for the people with stroke such as hemiplegic body (half body paralysed) by applying small charges of electricity to the muscle to induce the movement.
Mohamed Nasir, Noorhamizah
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Novel lnc-RNA, Named lnc-ORA, Is Identified by RNA-Seq Analysis, and Its Knockdown Inhibits Adipogenesis by Regulating the PI3K/AKT/mTOR Signaling Pathway

Cells, 2019
Obesity is closely associated with numerous adipogenic regulatory factors, including coding and non-coding genes. Long noncoding RNAs (lncRNAs) play a major role in adipogenesis.
Rui Cai, Guorong Tang, Que Zhang, Wenlong Yong, Wanrong Zhang, Junying Xiao, Changsheng Wei, Chun He, Gongshe Yang, Weijun Pang   +9 more
doaj   +1 more source