Mouse Skeletal Muscle Fiber-Type-Specific Macroautophagy and Muscle Wasting Are Regulated by a Fyn/STAT3/Vps34 Signaling Pathway [PDF]
Skeletal muscle atrophy induced by aging (sarcopenia), inactivity, and prolonged fasting states (starvation) is predominantly restricted to glycolytic type II muscle fibers and typical spares oxidative type I fibers.
Eijiro Yamada +5 more
doaj +2 more sources
Mechanical Properties of Single Muscle Fibers: Understanding Poor Muscle Quality in Older Adults with Diabetes [PDF]
Background While aging causes muscle weakness, type 2 diabetes mellitus (T2DM) is also considered a high-risk factor for the induction of skeletal muscle weakness.
Eun-Jeong Lee +4 more
doaj +1 more source
Effects of botulinum toxin type A on healing of injured skeletal muscles
Objectives: (1) Evaluation of microscopic healing of skeletal muscle fibers after injuries, especially the arrangement of new muscle fibers and scar tissue diameter in the injury region.
A Ramin Shokravi +3 more
doaj +3 more sources
Background: The chemotherapeutic doxorubicin (DOX) promotes severe skeletal muscle atrophy, which induces skeletal muscle weakness and fatigue. Soluble guanylate cyclase (sGC) contributes to a variety of pathophysiological processes, but whether it is ...
Bo-ang Hu +13 more
doaj +1 more source
Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]
An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Quasthoff, Stefan +3 more
core +1 more source
Development of Microfluidic Stretch System for Studying Recovery of Damaged Skeletal Muscle Cells
The skeletal muscle occupies about 40% mass of the human body and plays a significant role in the skeletal movement control. Skeletal muscle injury also occurs often and causes pain, discomfort, and functional impairment in daily living. Clinically, most
Wanho Kim +3 more
doaj +1 more source
Myoblast‐derived exosomes promote the repair and regeneration of injured skeletal muscle in mice
When skeletal muscle is damaged, satellite cells (SCs) are activated to proliferate rapidly and fuse with the damaged muscle fibers to form new muscle fibers, thereby promoting muscle growth and remodeling and repair of trauma.
Shusen Ji +11 more
doaj +1 more source
Skeletal muscle fiber plasticity: Heat shock proteins and satellite cell activation
Skeletal muscles have defensive and regenerative systems to protect them from severe injury and/or fiber degeneration. Several stresses, including muscle-contraction during exercise and heat stress, induce the specific proteins named heat shock proteins (
Yasuharu Oishi, Tomonori Ogata
doaj +1 more source
Skeletal Muscle Fiber Size and Capillarity
SummaryThe ATPase technique following preincubation in an acid medium (pH 3.8–4.0) was used to visualize capillaries. After preincubation at a pH of 4.5, in combination with the DPNH tetrazolium reductase, it was used to identify fiber types. A positive correlation has been demonstrated between fiber cross sectional area and C:F, indicating that large ...
A H, Sillau, N, Banchero
openaire +2 more sources
Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]
BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph +23 more
core +1 more source

