Skeletal muscle fiber plasticity: Heat shock proteins and satellite cell activation
Skeletal muscles have defensive and regenerative systems to protect them from severe injury and/or fiber degeneration. Several stresses, including muscle-contraction during exercise and heat stress, induce the specific proteins named heat shock proteins (
Yasuharu Oishi, Tomonori Ogata
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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]
BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph +23 more
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Skeletal Muscle Fiber Size and Capillarity
SummaryThe ATPase technique following preincubation in an acid medium (pH 3.8–4.0) was used to visualize capillaries. After preincubation at a pH of 4.5, in combination with the DPNH tetrazolium reductase, it was used to identify fiber types. A positive correlation has been demonstrated between fiber cross sectional area and C:F, indicating that large ...
A H, Sillau, N, Banchero
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Study of calcium sparks in skeletal and smooth muscle cells in normal and pathological conditions [PDF]
mTOR signaling influence a wide range of cellular process including protein synthesis (Iadevaia et al., 2012; Ma and Blenis, 2009; Thoreen et al., 2012), lipids synthesis (Lamming and Sabatini, 2013), transcription (Dibble and Manning, 2013; Vazquez ...
López, Rubén
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In addition to driving contraction of skeletal muscles, acetylcholine (ACh) acts as an anti-synaptogenic agent at neuromuscular junctions (NMJs). Previous studies suggest that aging is accompanied by increases in cholinergic activity at the NMJ, which ...
Sydney K. Vaughan +6 more
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Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency. [PDF]
The effect of the fast skeletal muscle troponin activator, CK-2066260, on calcium-induced force development was studied in skinned fast skeletal muscle fibers from wildtype (WT) and nebulin deficient (NEB KO) mice.
Eun-Jeong Lee +7 more
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Noninvasive Estimation of Myosin Heavy Chain Composition in Human Skeletal Muscle [PDF]
Purpose: Information on muscle fiber type composition is of great importance in muscle physiology and athletic performance. Because there are only a few techniques available that noninvasively and accurately provide an estimate of muscle fiber type ...
Rittweger, Jörn +17 more
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The significance of lipoprotein lipase in rat skeletal muscles
Lipoprotein lipase was assayed in extracts of acetone-ether powders of rat skeletal muscles. Enzyme activity in soleus had typical characteristics of lipoprotein lipase in other tissues: inhibition by molar NaCl and protamine sulfate and activation by ...
M H Tan, T Sata, R J Havel
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The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]
The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor +3 more
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Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane.
Dongwoo Hahn +6 more
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