Results 41 to 50 of about 167,552 (311)

Obestatin controls skeletal muscle fiber-type determination [PDF]

Scientific Reports, 2017
AbstractObestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and -independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and effector proteins. In this work, we describe a new level of activity where obestatin signaling plays a role in the formation, contractile
Santos-Zas, Icía, Cid-Díaz, Tania, González-Sánchez, Jessica, Gurriarán-Rodriguez, Uxía, Seoane-Mosteiro, Carlos, Porteiro, Begoña, Nogueiras, Rubén, Casabiell, Xesús, Luis Relova, José, Gallego, Rosalía, Mouly, Vincent, Pazos, Yolanda, Camiña, Jesus P.   +12 more
openaire   +2 more sources

CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism

The Journal of Clinical Investigation, 2023
Understanding how skeletal muscle fiber proportions are regulated is vital to understanding muscle function. Oxidative and glycolytic skeletal muscle fibers differ in their contractile ability, mitochondrial activity, and metabolic properties. Fiber-type
Young Jae Bahn, Hariom Yadav, Paolo Piaggi, Brent S. Abel, Oksana Gavrilova, Danielle A. Springer, Ioannis Papazoglou, Patricia M. Zerfas, Monica C. Skarulis, Alexandra C. McPherron, Sushil G. Rane   +10 more
doaj   +1 more source

Action potential-evoked calcium release is impaired in single skeletal muscle fibers from heart failure patients. [PDF]

PLoS ONE, 2014
Exercise intolerance in chronic heart failure (HF) has been attributed to abnormalities of the skeletal muscles. Muscle function depends on intact excitation-contraction coupling (ECC), but ECC studies in HF models have been inconclusive, due to ...
Marino DiFranco, Marbella Quiñonez, Perry Shieh, Gregg C Fonarow, Daniel Cruz, Mario C Deng, Julio L Vergara, Holly R Middlekauff   +7 more
doaj   +1 more source

Functional Classification of Skeletal Muscle Networks. I. Normal Physiology [PDF]

, 2012
Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models.
Subramaniam, Shankar, Wang, Yu, Winters, John   +2 more
core   +2 more sources

Influence of skeletal muscle heterogeneity on autophagic signaling and response

Autophagy Reports
Skeletal muscle is a heterogeneous tissue composed of fibers with distinct contractile, metabolic, and molecular characteristics. This intrinsic heterogeneity influences how individual fibers respond to physiological stimuli, pathological stress, and ...
Fasih A. Rahman, Joe Quadrilatero
doaj   +1 more source

FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension

BMC Musculoskeletal Disorders, 2007
Background Skeletal muscle atrophy can occur under many different conditions, including prolonged disuse or immobilization, cachexia, cushingoid conditions, secondary to surgery, or with advanced age. The mechanisms by which unloading of muscle is sensed
Gerrard Dave, Breur Gert, Olsen Aaron, Eash John, Hannon Kevin   +4 more
doaj   +1 more source

Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging [PDF]

, 2017
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers
Ciciliot, Stefano, Mann, Matthias, Murgia, Marta, Nagaraj, Nagarjuna, Reggiani, Carlo, Schiaffino, Stefano, Toniolo, Luana, Vindigni, Vincenzo   +7 more
core   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders

All Life, 2023
Skeletal muscle comprises the major organ system in our bodies and is the effector tissue for fundamental processes, such as movement, breathing and glucose homeostasis.
Hyun-Jun Kim, Da-Woon Jung, Darren R. Williams   +2 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source