Results 41 to 50 of about 98,011 (316)

Action potential-evoked calcium release is impaired in single skeletal muscle fibers from heart failure patients. [PDF]

PLoS ONE, 2014
Exercise intolerance in chronic heart failure (HF) has been attributed to abnormalities of the skeletal muscles. Muscle function depends on intact excitation-contraction coupling (ECC), but ECC studies in HF models have been inconclusive, due to ...
Marino DiFranco, Marbella Quiñonez, Perry Shieh, Gregg C Fonarow, Daniel Cruz, Mario C Deng, Julio L Vergara, Holly R Middlekauff   +7 more
doaj   +1 more source

The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition [PDF]

, 2010
Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions ...
Grocott Mike P., Edwards, Lindsay M, Holloway, CJ, Mike P Grocott, Grocott, Mike P, Edwards, LM, Neubauer, Stefan, Hugh E Montgomery, Murray Andrew J., Peter A Robbins, Robbins Peter A., Robbins, Peter A., Montgomery, Hugh E., Robbins, Peter A, Grocott, Mike P.W., Tyler Damian J., Earnest, Conrad P., Holloway Cameron J., Damian J Tyler, Murray, Andrew J, Caudwell Xtreme Everest Research Group, Clarke Kieran, Montgomery, Hugh E, Kemp Graham J., Andrew J Murray, Murray, AJ, ?, ?, Neubauer Stefan, Clarke, K, Robbins, Peter, Denny Levett, Holloway, Cameron J, Holloway, Cameron J., Kieran Clarke, Graham J Kemp, Montgomery Hugh E., Murray, Andrew J., Grocott, Mike P., Levett Denny, Grocott, MP, Caudwell Xtreme Everest Res Grp, Lindsay M Edwards, Tyler, Damian, Robbins, PA, Edwards, Lindsay M., Kemp, Graham J, Montgomery, HE, Tyler, Damian J, Levett, D, Kemp, Graham J., Neubauer, S, Tyler, DJ, Kemp, GJ, Levett, Denny, Clarke, Kieran, Cameron J Holloway, Tyler, Damian J., Stefan Neubauer, Edwards Lindsay M.   +58 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres [PDF]

, 1989
The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as K+ channel openers, on the electrical activity of human skeletal muscle.
Lehmann-Horn, Frank, Grafe, Peter, Spuler, A.   +2 more
core   +1 more source

Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders

All Life, 2023
Skeletal muscle comprises the major organ system in our bodies and is the effector tissue for fundamental processes, such as movement, breathing and glucose homeostasis.
Hyun-Jun Kim, Da-Woon Jung, Darren R. Williams   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The role of the coactivators PGC-1α and PGC-1β in retina and skeletal muscle [PDF]

, 2011
Peroxisome proliferator-activated receptor γ coactivator- 1 (PGC-1) designates a family of coactivators consisting of PGC-1α, PGC-1β and PRC. By associating with transcription factors like nuclear receptors, they induce transcription of target genes that
Egger, A, Egger, Anna Franziska
core   +1 more source

GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle

JCI Insight, 2023
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expression ...
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams   +21 more
doaj   +1 more source

Advanced Fiber Type-Specific Protein Profiles Derived from Adult Murine Skeletal Muscle

Proteomes, 2021
Skeletal muscle is a heterogeneous tissue consisting of blood vessels, connective tissue, and muscle fibers. The last are highly adaptive and can change their molecular composition depending on external and internal factors, such as exercise, age, and ...
Britta Eggers, Karin Schork, Michael Turewicz, Katalin Barkovits, Martin Eisenacher, Rolf Schröder, Christoph S. Clemen, Katrin Marcus   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source